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Specialty: Hematology
Drug: Insulin

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Total 12 results found since Jan 2013.

The voltage-gated K + channel Kv1.3 modulates platelet motility and α 2 β 1 integrin-dependent adhesion to collagen
Platelets. 2021 Aug 4:1-11. doi: 10.1080/09537104.2021.1942818. Online ahead of print.ABSTRACTKv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet function is poorly understood. Here we show that Kv1.3-deficient platelets display enhanced ADP-evoked platelet aggregation and secretion, and an increased surface expression of platelet integrin αIIb. In contrast, platelet adhesion and thrombus formation in vitro under arterial shear condit...
Source: Platelets - August 5, 2021 Category: Hematology Authors: Joy R Wright Sarah Jones Sasikumar Parvathy Leonard K Kaczmarek Ian Forsythe Richard W Farndale Jonathan M Gibbins Martyn P Mahaut-Smith Source Type: research

Coagulation markers and functional outcome in acute ischemic stroke: Impact of intensive versus standard hyperglycemia control
CONCLUSIONS: Intensive glucose control induced greater alterations in coagulation biomarkers than standard treatment, and these were associated with a favorable functional outcome at 3 months after AIS.PMID:34278192 | PMC:PMC8279129 | DOI:10.1002/rth2.12563
Source: Thrombosis and Haemostasis - July 19, 2021 Category: Hematology Authors: Nina T Gentile A Koneti Rao Hannah Reimer Fabiola Del Carpio-Cano Viswanathan Ramakrishnan Qi Pauls William G Barsan Askiel Bruno iSPOT, Neurological Emergencies Treatment Trials Network (NETT) Investigators Source Type: research

Systemic vascular resistance predicts the development of hypertension: the cardiovascular risk in young Finns study.
Conclusions: These findings suggest that systemic vascular resistance index predicts the incidence of hypertension in young adults and that the evaluation of systemic hemodynamics could provide an additional tool for hypertension risk prediction. PMID: 32597238 [PubMed - as supplied by publisher]
Source: Blood Pressure - July 2, 2020 Category: Hematology Tags: Blood Press Source Type: research

Type 2 Diabetes Mellitus in Patients with Sickle Cell Disease: A Population-Based Longitudinal Analysis of Three Cohorts
ConclusionWe present evidence describing the prevalence of T2DM in patients with SCD both in a commercially-insured population and from an institution-based clinical cohort. These findings were similar to a general African American population with an increasing trend in T2DM over recent years. These trends support the routine screening for T2DM in patients with SCD, especially those of older age and with presence of comorbid hypertension and/or dyslipidemia.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Zhou, J., Han, J., Nutescu, E. A., Galanter, W., Walton, S. M., Gordeuk, V. R., Saraf, S. L., Srisuwananukorn, A., Calip, G. S. Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster III Source Type: research

Association of whole blood viscosity with non-alcoholic fatty liver disease.
CONCLUSIONS: The findings showed that WBV at low shear stress is increased in NAFLD. Moreover, WBV at low shear stress is independently associated with NAFLD even after adjusting other cardiovascular risk factors. PMID: 26444605 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - September 25, 2015 Category: Hematology Authors: Yu XY, Li Y, Liu T, Wang RT Tags: Clin Hemorheol Microcirc Source Type: research

Associations of pentraxin 3 with cardiovascular disease: the Multi‐Ethnic Study of Atherosclerosis
ConclusionsIn these apparently healthy adults, PTX3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independently of CRP and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP, and may provide additional insights into the development and progression of atherosclerosis.
Source: Journal of Thrombosis and Haemostasis - June 10, 2014 Category: Hematology Authors: N. S. Jenny, R. S. Blumenthal, R. A. Kronmal, J. I. Rotter, D. S. Siscovick, B. M. Psaty Tags: Original Article Source Type: research

Associations of Pentraxin 3 with Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
CONCLUSIONS: In these apparently healthy adults, PTX3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independent of CRP and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP and may provide additional insight into the development and progression of atherosclerosis. This article is protected by copyright. All rights reserved. PMID: 24628740 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 13, 2014 Category: Hematology Authors: Jenny NS, Blumenthal RS, Kronmal RA, Rotter JI, Siscovick DS, Psaty BM Tags: J Thromb Haemost Source Type: research

Associations of Pentraxin 3 with Cardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis
ConclusionsIn these apparently healthy adults, PTX3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independent of CRP and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP and may provide additional insight into the development and progression of atherosclerosis.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - March 1, 2014 Category: Hematology Authors: Nancy Swords Jenny, Roger S. Blumenthal, Richard A. Kronmal, Jerome I. Rotter, David S. Siscovick, Bruce M. Psaty Tags: Original Article ‐ Vascular Biology Source Type: research