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Stroke-induced hexokinase 2 in circulating monocytes exacerbates vascular inflammation and atheroprogression
CONCLUSIONS: Stroke-induced monocyte Hk2 upregulation is a key mechanism underlying post-stroke vascular inflammation and atheroprogression.PMID:36893911 | DOI:10.1016/j.jtha.2023.02.021
Source: Thrombosis and Haemostasis - March 9, 2023 Category: Hematology Authors: Yang Sun Lujun Zhang Yu Cao Xingsheng Li Fan Liu Xiaoxiao Cheng Jianlin Du Haitao Ran Zhigang Wang Yongyong Li Yuxing Feng Liwen Liang Wenhua Su N D Melgiri Hong Zhang Rongzhong Huang Source Type: research

Platelet Indices and Risk of Death and Cardiovascular Events: Results from a Large Population-Based Cohort Study.
In conclusion, elevated platelet count is associated with higher mortality and risk of CV events, regardless of previous MI and stroke. Platelet count may thus be a useful marker for further stratification of CV risk, and especially of death. PMID: 31430798 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 19, 2019 Category: Hematology Authors: Patti G, Di Martino G, Ricci F, Renda G, Gallina S, Hamrefors V, Melander O, Sutton R, Engström G, De Caterina R, Fedorowski A Tags: Thromb Haemost Source Type: research

Health-related knowledge on hypertension among the Portuguese population: results from a population-based survey.
CONCLUSIONS: This study provided a quantitative estimate of the gaps in health-related knowledge about hypertension among the general population. Understanding the barriers that hinder the achievement of health-related knowledge on hypertension is expected to contribute for the global improvement of prevention and management of hypertension. PMID: 29366359 [PubMed - as supplied by publisher]
Source: Blood Pressure - January 26, 2018 Category: Hematology Tags: Blood Press Source Type: research

Treatment Failure in Patients Receiving Direct Oral Anticoagulants: Clinical Management and Outcomes from a Single-Center Review of 59 Consecutive Patients
In this study, we sought to characterise DOAC treatment failures in our institution, and to rationalise the subsequent anticoagulation strategies in this setting. All VTE patients starting a DOAC at our centre are followed in a consultant-led clinic. Cases of suspected treatment failure are also referred from other specialities and primary care. Between September 2014 and May 2018, we identified 59 consecutive patients (male/female: 34/25) in whom a DOAC treatment failure was diagnosed, including non-resolution of the presenting complaint, and recurrence of or a new thrombotic event. Patient mean age at DOAC initiation was...
Source: Blood - November 21, 2018 Category: Hematology Authors: McIlroy, G., Smith, N., Lokare, A., Beale, K., Kartsios, C. Tags: 332. Antithrombotic Therapy Source Type: research

Bugs in the system
Bugs play a large role in our life. Bugs can be either good, or bad for us. Microorganisms, such as gut microbiota, are usually beneficial to us. They provide a barrier to pathogenic organisms and help to digest our food. However, microbiota also produce Trimethylamine-N-oxide (TMAO), a metabolite of dietary phosphatidylcholine and L-carnitine, that has been recently been shown to increase the risk of arterial thrombotic events, such as myocardial infarction and stroke. In this issue of Thrombosis Research, Reiner and colleagues have investigated whether plasma levels of TMAO also associate with recurrent venous thromboemb...
Source: Thrombosis Research - January 30, 2019 Category: Hematology Authors: Henri H. Versteeg, Marc Rodger Source Type: research

Assessing patient preferences for switching from warfarin to direct oral anticoagulants
This study assessed patient preference for warfarin or DOAC based on a willingness to pay more for potential DOAC benefits. Current warfarin patients with atrial fibrillation or venous thromboembolism enrolled in the University of Utah Health Thrombosis Service were given a one-time electronic survey that assessed preferences between warfarin and DOACs using scenarios comparing effectiveness, safety, and convenience. When DOACs were preferred, patients were asked how much more they would be willing to pay monthly for the perceived advantages associated with DOACs. With 123 completed surveys, 68% of patients preferred to st...
Source: Journal of Thrombosis and Thrombolysis - October 19, 2019 Category: Hematology Source Type: research

Self-rated health and venous thromboembolism among middle-aged women: a population-based cohort study
This study supports previous results with varico se veins and waist circumference as strong predictors of VTE. Poor self-rated health does not seem to be a valid predictor of VTE. Among lifestyle-related parameters, smoking was significantly associated with risk of VTE. We could also confirm the effect of the other already known risk factors.
Source: Journal of Thrombosis and Thrombolysis - November 18, 2019 Category: Hematology Source Type: research

The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis.
This study identified ceRNAs network regulated by TAN and elucidated the ncRNAs profile and signal pathways to attenuate AS comprehensively. This research would contribute to further research on the pathogenesis of AS, and facilitate the development of novel therapeutics targeting ncRNAs. PMID: 32337768 [PubMed - as supplied by publisher]
Source: Journal of Leukocyte Biology - April 25, 2020 Category: Hematology Authors: Chen W, Guo S, Li X, Song N, Wang D, Yu R Tags: J Leukoc Biol Source Type: research

Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells.
Abstract Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic pro...
Source: Clinical Hemorheology and Microcirculation - September 6, 2020 Category: Hematology Authors: Krüger-Genge A, Jung F, Hufert F, Jung EM, Küpper JH, Storsberg J Tags: Clin Hemorheol Microcirc Source Type: research

Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.
CONCLUSION: Pharmacological targeting of FXI reduced atherogenesis in Ldlr-/- mice. Interference with the contact activation system may safely reduce development or progression of atherosclerosis. PMID: 33421301 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 9, 2021 Category: Hematology Authors: Ngo ATP, Jordan KR, Mueller PA, Hagen MW, Reitsma SE, Puy C, Revenko AS, Lorentz CU, Tucker EI, Cheng Q, Hinds MT, Fazio S, Monia BP, Gailani D, Gruber A, Tavori H, McCarty OJT Tags: J Thromb Haemost Source Type: research

Pitavastatin Compared with Differential Intervention Trial by Standard Therapy on Cardiovascular Events in Patients with Dyslipidemia on Chronic Hemodialysis (DIALYSIS): A Randomized Controlled Trial
Conclusion: Our study has demonstrated that aggressive intervention with pitavastatin is more effective than the standard (dietary) therapy for improving the clinical outcomes in patients with dyslipidemia on chronic hemodialysis.Blood Purif
Source: Blood Purification - January 30, 2023 Category: Hematology Source Type: research