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Specialty: Hematology
Condition: Ischemic Stroke

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Total 1017 results found since Jan 2013.

Hypercoagulability on Thromboelastography Can Predict the Functional Outcome in Patients with Acute Ischemic Stroke
CONCLUSION: A R of <5 min was a negative predictor of functional independence. Frequent HT, END, and different stroke etiologies according to the R may be the cause of poor outcome after ischemic stroke.PMID:37130549 | DOI:10.1055/a-2084-5018
Source: Thrombosis and Haemostasis - May 2, 2023 Category: Hematology Authors: Jae-Chan Ryu Jae-Han Bae Sang Hee Ha Bum Joon Kim Sang-Beom Jeon Dong-Wha Kang Sun U Kwon Jong S Kim Jun Young Chang Source Type: research

Association between polycythemia and risk of ischemic stroke in males based on the National Health Insurance Service-Health Screening Cohort
CONCLUSIONS: The risk of ischemic stroke was higher in participants with polycythemia than in those with normocythemia.PMID:37249134 | DOI:10.1080/17474086.2023.2218610
Source: Expert Review of Hematology - May 30, 2023 Category: Hematology Authors: Hyo-Sun You Sang-Jun Shin Joungyoun Kim Hee-Taik Kang Source Type: research

Association between polycythemia and risk of ischemic stroke in males based on the national health insurance service-health screening cohort
CONCLUSIONS: The risk of ischemic stroke was higher in participants with polycythemia than in those with normocythemia.PMID:37249134 | DOI:10.1080/17474086.2023.2218610
Source: Expert Review of Hematology - May 30, 2023 Category: Hematology Authors: Hyo-Sun You Sang-Jun Shin Joungyoun Kim Hee-Taik Kang Source Type: research

Sexual dimorphism in peripheral blood cell characteristics linked to recanalization success of endovascular thrombectomy in acute ischemic stroke
AbstractEndovascular thrombectomy (EVT) success to treat  acute ischemic stroke varies with factors like stroke etiology and clot composition, which can differ between sexes. We studied if sex-specific blood cell characteristics (BCCs) are related to recanalization success. We analyzed electronic health records of 333 EVT patients from a single interve ntion center, and extracted 71 BCCs from the Sapphire flow cytometry analyzer. Through Sparse Partial Least Squares Discriminant Analysis, incorporating cross-validation and stability selection, we identified BCCs associated with successful recanalization (TICI 3) in ...
Source: Journal of Thrombosis and Thrombolysis - August 18, 2023 Category: Hematology Source Type: research

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.
Abstract Wild type (WT) activated protein C (APC) and cytoprotective-selective APC variants such as 3K3A-APC (<10% anticoagulant but normal cytoprotective activity) are neuroprotective in murine focal ischemic stroke models. Here we compared the neuroprotective effects of the anticoagulant-selective E149A-APC variant (>3-fold increased anticoagulant activity but defective cytoprotective activities) to those of the cytoprotective-selective 5A-APC variant (<10% anticoagulant activity). After transient distal middle cerebral artery occlusion, mice received a vehicle, E149A-APC or 5A-APC at 0.2mg/kg at 4h aft...
Source: Blood Cells, Molecules and Diseases - March 28, 2013 Category: Hematology Authors: Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV Tags: Blood Cells Mol Dis Source Type: research

Sickle‐cell disease stroke throughout life: A retrospective study in an adult referral center
Abstract Strokes are one of the most severe complications of sickle‐cell disease. Most studies have been restricted to children with sickle‐cell disease. To better understand the characteristics and follow‐up of strokes occurring from childhood to adulthood, we undertook a retrospective cohort study of 69 stroke patients among the 2,875 patients consulting at the French Adult Sickle‐Cell Disease Referral Center. Between 1970 and 2008, they had experienced 104 strokes: 80 ischemic, 22 hemorrhagic and 2 intracranial sinus thromboses. Coma and/or fatal outcomes underscored the severity of strokes in sickle‐cell dise...
Source: American Journal of Hematology - November 8, 2013 Category: Hematology Authors: Antoine Gueguen, Matthieu Mahevas, Ruben Nzouakou, Hassan Hosseini, Anoosha Habibi, Dora Bachir, Pierre Brugière, François Lionnet, Jean‐Antoine Ribeil, Bertrand Godeau, Robert Girot, Vahid Ibrahima, David Calvet, Frédéric Galactéros, Pablo Bartolu Tags: Research Article Source Type: research

Unanswered questions and research priorities to optimise stroke prevention in atrial fibrillation with the new oral anticoagulants.
Abstract This review article discusses the following, as yet unanswered, questions and research priorities to optimise patient management and stroke prevention in atrial fibrillation with the new direct oral anticoagulants (NOACs): 1. In patients prescribed a NOAC, can the anticoagulant effects or plasma concentrations of the NOACs be measured rapidly and reliably and, if so, can "cut-off points" between which anticoagulation is therapeutic (i.e. the "therapeutic range") be defined? 2. In patients who are taking a NOAC and bleeding (e.g. intracerebral haemorrhage), can the anticoagulant effects of the direct NOACs...
Source: Thrombosis and Haemostasis - November 28, 2013 Category: Hematology Authors: Hankey GJ Tags: Thromb Haemost Source Type: research

Clopidogrel High-on-Treatment Platelet Reactivity in Acute Ischemic Stroke Patients
Conclusions: Clopidogrel-HTPR was found in 44% of the patients with acute ischemic stroke. Besides time-dependency of the clopidogrel effect, major risk factors for clopidogrel-HTPR were diabetes mellitus and higher HbA1c values. Further investigations are required to analyse if a function test guided strategy has the potential to optimize the antiplatelet therapy of acute stroke patients.
Source: Thrombosis Research - January 9, 2014 Category: Hematology Authors: Saskia H. Meves, Kay D. Schröder, Heinz G. Endres, Christos Krogias, Jan C. Krüger, Horst Neubauer Tags: Platelets and cell biology Source Type: research

Evidence for the Prevention and Treatment of Stroke in Dialysis Patients
Abstract The risks of both ischemic and hemorrhagic stroke are particularly high in dialysis patients of any age and outcomes are poor. It is therefore important to identify strategies that safely minimize stroke risk in this population. Observational studies have been unable to clarify the relative importance of traditional stroke risk factors such as blood pressure and cholesterol in those on dialysis, and are affected by biases that usually make them an inappropriate source of data on which to base therapeutic decisions. Well‐conducted randomized trials are not susceptible to such biases and can reliably investigate t...
Source: Seminars In Dialysis - May 1, 2014 Category: Hematology Authors: William Herrington, Richard Haynes, Natalie Staplin, Jonathan Emberson, Colin Baigent, Martin Landray Tags: Review Source Type: research

Acute ischemic stroke patients with diabetes should not be excluded from intravenous thrombolysis
Abstract The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS patients admitted to an stroke unit. Demographic data, vascular risk factors, comorbidity, stroke severity and 3-month follow-up outcome (modified Rankin Scale) were compared according to prior diagnosis of DM and the use or not of IVT. A total of 1,139 IS patients were admitted; 283 (24.8 %...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Ischemic stroke associated with immune thrombocytopenia
The objective of this study was to review all cases in literature in which the clinical manifestations of ischemic stroke and immune thrombocytopenia (ITP) were presented in the same patient including a new case of our own and discuss the possible mechanism and management of this syndrome. We reviewed 12 reports in which 18 cases were diagnosed as ischemic stroke and ITP. The clinical manifestations and ischemic lesion patterns of the 18 cases and our new case were analyzed in detail to elucidate the characteristics and management of this kind of syndrome. Of all the cases, 8 females and 10 males, 10 of them were Koreans; ...
Source: Journal of Thrombosis and Thrombolysis - November 8, 2014 Category: Hematology Source Type: research

Is plasma C3 and C4 levels useful in young cerebral ischemic stroke patients? Associations with prognosis at 3 months
Abstract Plasma complement C3 and C4 act as risk factor for vascular diseases related to atherosclerosis. The association C3 and C4 levels in young ischemic stroke patients with the prognosis were still not unknown. We conducted this study to establish the significance of admission C3 and C4 levels as a possible predictor of 3 months prognosis in young patients with acute ischemic stroke. We conducted this study in 1,451 young Chinese patients as determined by the modified Rankin Scale at 3 months. Bivariate logistic regression analyses were used to determine the risk factors of outcome in male and female patie...
Source: Journal of Thrombosis and Thrombolysis - February 1, 2015 Category: Hematology Source Type: research

Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study
ConclusionsThese results support the importance of contact activation pathway‐dependent TG as a risk factor for ischemic stroke and indicate the importance of F12 SNPs on TG ex vivo and in vivo.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 1, 2015 Category: Hematology Authors: N. C. Olson, S. Butenas, L. A. Lange, E. M. Lange, M. Cushman, N. S. Jenny, J. Walston, J. C. Souto, J. M. Soria, G. Chauhan, S. Debette, W.T. Longstreth, S. Seshadri, A.P. Reiner, R. P. Tracy Tags: Original Article ‐ Coagulation Source Type: research

Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study
ConclusionsThese results support the importance of contact activation pathway‐dependent TG as a risk factor for ischemic stroke, and indicate the importance of F12 SNPs for TG ex vivo and in vivo.
Source: Journal of Thrombosis and Haemostasis - September 14, 2015 Category: Hematology Authors: N. C. Olson, S. Butenas, L. A. Lange, E. M. Lange, M. Cushman, N. S. Jenny, J. Walston, J. C. Souto, J. M. Soria, G. Chauhan, S. Debette, W. T. Longstreth, S. Seshadri, A. P. Reiner, R. P. Tracy Tags: Original Article Source Type: research