Health-related quality of life in peritoneal dialysis patients: A narrative review.
Abstract Health-related quality of life (HRQOL) is an important aspect of patients´ health that should be an integral part of the evaluation of patient-centered outcomes, not least because HRQOL associates with patients´ morbidity and mortality. This applies also to chronic kidney disease patients, including those dependent on renal replacement therapies, the type of which may influence patients´ perception of HRQOL. Several studies have addressed HRQOL in chronic kidney disease patients undergoing renal replacement therapies, especially transplanted patients and hemodialysis patients, while publ...
Source: Seminars in Dialysis - December 21, 2018 Category: Urology & Nephrology Authors: Aguiar R, Pei M, Qureshi AR, Lindholm B Tags: Semin Dial Source Type: research

Transmission of hepatitis C virus in the dialysis setting and strategies for its prevention.
Abstract Hepatitis C virus (HCV) infection is more common among hemodialysis patients than the general population and transmission of HCV in dialysis clinics has been reported. In the context of the increased morbidity and mortality associated with HCV infection in the end stage renal disease population, it is important that dialysis clinics have processes in place for ensuring recommended infection control practices, including Standard Precautions, through regular audits and training of the staff. This review will summarize the epidemiology of HCV infection and risk factors for HCV transmission among hemodialysis...
Source: Seminars in Dialysis - December 19, 2018 Category: Urology & Nephrology Authors: Nguyen DB, Bixler D, Patel PR Tags: Semin Dial Source Type: research

Pharmacokinetics and important drug-drug interactions to remember when treating advanced chronic kidney disease patients with hepatitis C direct acting anti-viral therapy.
Abstract Hepatitis C direct acting antiviral (DAA) therapy has evolved so that infected patients with advanced chronic kidney disease (CKD) can now anticipate the opportunity for sustained virologic response equivalent to that of the broader population of patients with hepatitis C. This has revolutionized the field of transplantation as it relates to renal transplant candidates with hepatitis C and the use of grafts from hepatitis C virus (HCV) viremic donors. In treating this population of patients, special consideration must be given to the timing of anti-viral therapy and drug-drug interactions. Herein we revie...
Source: Seminars in Dialysis - December 17, 2018 Category: Urology & Nephrology Authors: Cohen E, Liapakis A Tags: Semin Dial Source Type: research

Considering hepatitis C virus infection as a systemic disease.
Abstract Hepatitis C virus (HCV) infection has been demonstrated to result in several adverse hepatic outcomes and has been associated with a number of important extrahepatic manifestations. The scope of extrahepatic clinical possibilities includes systemic diseases such as vasculitis and lymphoproliferative disorders, cardiovascular disease, myalgia, arthritis, and sicca syndrome. These end-organ effects of HCV may dominate the clinical course beyond the hepatic complications and significantly worsen the long-term prognosis of infected patients. Until several years ago, the standard of care for the treatment of H...
Source: Seminars in Dialysis - December 13, 2018 Category: Urology & Nephrology Authors: Cacoub P, Comarmond C Tags: Semin Dial Source Type: research

The epidemiology of HCV infection in patients with advanced CKD/ESRD: A global perspective.
Abstract Liver disease in patients with chronic kidney disease (CKD) is most commonly due to hepatitis C virus (HCV) and contributes to increased rates of mortality. Among the pre-dialysis population, the estimated prevalence of anti-HCV positivity is based on few, limited-size studies. In hemodialysis patients however, HCV remains very prevalent despite large declines in seropositivity rates in dialysis facilities in developed countries after preventive measures were adopted in the 1990s. Recent surveys indicate that the HCV seropositivity prevalence ranges from 1.4%-28.3%, and 4.7%-41.9%, among maintenance dialy...
Source: Seminars in Dialysis - December 9, 2018 Category: Urology & Nephrology Authors: Fabrizi F, Messa P Tags: Semin Dial Source Type: research

Management and treatment of the HCV-infected kidney transplant patient.
Abstract The prevalence of hepatitis C virus infection is increased in patients with end stage kidney disease compared to the general population and is an adverse outcome determinant. Direct-acting antiviral therapy for hepatitis C virus is changing the management paradigm of infected kidney transplant candidates and recipients, with potential to reduce patient morbidity and mortality. This review describes the hepatic and nonhepatic manifestations of hepatitis C virus in kidney transplant patients as well as management and treatment strategies to optimize transplant outcomes, highlighting the importance of direct...
Source: Seminars in Dialysis - December 9, 2018 Category: Urology & Nephrology Authors: Wong T, Bloom RD Tags: Semin Dial Source Type: research

What lies downstream: Cellular oxygen delivery during hemodialysis.
Abstract Hemodialysis has been linked to structural and functional damage to vital organs such as the brain and heart, possibly via repetitive intradialytic organ ischemia. There is increasing recognition that tissue ischemia can occur without changes in standard hemodynamic parameters such as blood pressure, leading to interest in more direct assessment of the adequacy of oxygen delivery to tissues. In this article, we discuss our current understanding of what happens to cellular oxygen delivery during hemodialysis: we review the underlying physiology, potential measurement techniques, and the clinical literature...
Source: Seminars in Dialysis - December 4, 2018 Category: Urology & Nephrology Authors: MacEwen C, Watkinson P, Tarassenko L, Pugh C Tags: Semin Dial Source Type: research

Summary of the 2018 Kidney Disease Improving Global Outcomes (KDIGO) Guideline on hepatitis C in chronic kidney disease.
Abstract KDIGO recently updated its clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus (HCV) infection in patients with chronic kidney disease (CKD). The management of HCV in patients with CKD has dramatically shifted over the past 10 years with the development of direct-acting antiviral (DAA) agents and subsequent demonstration of their efficacy in CKD populations. The opportunity to cure HCV with DAA treatment has impacted all aspects of the KDIGO guideline on HCV in CKD including: (a) HCV diagnosis in CKD populations; (b) HCV treatment in CKD populatio...
Source: Seminars in Dialysis - November 29, 2018 Category: Urology & Nephrology Authors: Gordon CE, Balk EM, Francis JM Tags: Semin Dial Source Type: research

The association of hepatitis C infection with the onset of CKD and progression into ESRD.
Abstract Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular diseases also occur and may be significantly under-recognized. HCV may cause glomerular disease by immune complex deposition; however, other potential mechanisms by which HCV promotes CKD include a direct cytopathic effect of the virus on renal tissue, and by its association with accelerated ...
Source: Seminars in Dialysis - November 29, 2018 Category: Urology & Nephrology Authors: Henson JB, Sise ME Tags: Semin Dial Source Type: research

ESRD patients coinfected with human immunodeficiency virus and Hepatitis C: Outcomes and management challenges
AbstractHIV infection is a major public health problem worldwide. Due to shared modes of acquisition, many HIV+ patients are coinfected with Hepatitis C. HIV/HCV coinfected patients have an increased burden of chronic kidney disease and are more likely to progress to end ‐stage renal disease. Dialysis survival is diminished in the coinfected population, even in the contemporary era. Kidney transplantation offers a survival benefit over remaining on dialysis; however, posttransplant outcomes are inferior compared to patients with HIV infection alone. Direct acting antiviral agents may offer an opportunity to improve patie...
Source: Seminars In Dialysis - November 26, 2018 Category: Hematology Authors: Deirdre Sawinski Tags: HEPATITIS C VIRUS INFECTION IN PATIENTS WITH KIDNEY DISEASE: A ROADMAP FOR NEPHROLOGISTS Source Type: research

Treating hepatitis C virus in dialysis patients: How, when, and why?
AbstractThe identification of hepatitis C virus (HCV) occurred in 1989, and soon thereafter, it was recognized that there was a higher prevalence of anti ‐HCV seropositivity in patients with end‐stage renal disease (ESRD) when compared to the general population. Multiple extrahepatic manifestations have been associated with HCV infection in patients with ESRD; these include an increased prevalence and risk of cardiovascular complications, insulin resistance, diabetes mellitus, and lymphoproliferative disorders. Infection with HCV has also been associated with an increased relative risk of mortality in the ESRD patient ...
Source: Seminars In Dialysis - November 26, 2018 Category: Hematology Authors: Javier Pagan, Marco Ladino, David Roth Tags: HEPATITIS C VIRUS INFECTION IN PATIENTS WITH KIDNEY DISEASE: A ROADMAP FOR NEPHROLOGISTS Source Type: research

Risks, benefits, and ethical questions associated with transplanting kidneys from hepatitis C virus ‐infected donors into hepatitis C virus‐negative patients
AbstractUtilization of kidneys from hepatitis C virus (HCV) ‐infected deceased donors has the potential to increase the number of kidney transplants by 500‐1000 (or more) each year. This increase in the number of kidney transplants offers major opportunities to extend survival and improve quality of life for patients infected with HCV, as well as uninfec ted recipients. However, due to a lack of prospective safety and efficacy data on a sufficient number of HCV‐negative recipients who received a kidney from a HCV‐infected donor, as well as key logistical barriers, the practice of transplanting HCV‐infected organs...
Source: Seminars In Dialysis - November 26, 2018 Category: Hematology Authors: David Goldberg, Peter P. Reese Tags: HEPATITIS C VIRUS INFECTION IN PATIENTS WITH KIDNEY DISEASE: A ROADMAP FOR NEPHROLOGISTS Source Type: research

Risks, benefits, and ethical questions associated with transplanting kidneys from hepatitis C virus-infected donors into hepatitis C virus-negative patients.
Abstract Utilization of kidneys from hepatitis C virus (HCV)-infected deceased donors has the potential to increase the number of kidney transplants by 500-1000 (or more) each year. This increase in the number of kidney transplants offers major opportunities to extend survival and improve quality of life for patients infected with HCV, as well as uninfected recipients. However, due to a lack of prospective safety and efficacy data on a sufficient number of HCV-negative recipients who received a kidney from a HCV-infected donor, as well as key logistical barriers, the practice of transplanting HCV-infected organs i...
Source: Seminars in Dialysis - November 26, 2018 Category: Urology & Nephrology Authors: Goldberg D, Reese PP Tags: Semin Dial Source Type: research

Treating hepatitis C virus in dialysis patients: How, when, and why?
Abstract The identification of hepatitis C virus (HCV) occurred in 1989, and soon thereafter, it was recognized that there was a higher prevalence of anti-HCV seropositivity in patients with end-stage renal disease (ESRD) when compared to the general population. Multiple extrahepatic manifestations have been associated with HCV infection in patients with ESRD; these include an increased prevalence and risk of cardiovascular complications, insulin resistance, diabetes mellitus, and lymphoproliferative disorders. Infection with HCV has also been associated with an increased relative risk of mortality in the ESRD pat...
Source: Seminars in Dialysis - November 26, 2018 Category: Urology & Nephrology Authors: Pagan J, Ladino M, Roth D Tags: Semin Dial Source Type: research

Direct acting anti-viral medications for hepatitis C: Clinical trials in patients with advanced chronic kidney disease.
Abstract Hepatitis C is a global health concern, with important implications in chronic kidney disease (CKD) due to its increased prevalence in this population. Patients with advanced CKD have until recently been excluded from the pivotal direct acting anti-viral (DAA) trials, which have demonstrated high virological cure numbers. Sofosbuvir-free DAAs dasabuvir, ombitasvir/paritaprevir/ritonavir with or without ribavirin, and elbasvir/grazoprevir are well-tolerated in patients with genotype 1 and 4 CHC with CKD 4 or 5 (including HD), with virologic cure rates of above 90%, in both single-arm and placebo-controlled...
Source: Seminars in Dialysis - November 26, 2018 Category: Urology & Nephrology Authors: Bruchfeld A, Lindahl K Tags: Semin Dial Source Type: research

ESRD patients coinfected with human immunodeficiency virus and Hepatitis C: Outcomes and management challenges.
Abstract HIV infection is a major public health problem worldwide. Due to shared modes of acquisition, many HIV+ patients are coinfected with Hepatitis C. HIV/HCV coinfected patients have an increased burden of chronic kidney disease and are more likely to progress to end-stage renal disease. Dialysis survival is diminished in the coinfected population, even in the contemporary era. Kidney transplantation offers a survival benefit over remaining on dialysis; however, posttransplant outcomes are inferior compared to patients with HIV infection alone. Direct acting antiviral agents may offer an opportunity to improv...
Source: Seminars in Dialysis - November 26, 2018 Category: Urology & Nephrology Authors: Sawinski D Tags: Semin Dial Source Type: research

Direct acting anti ‐viral medications for hepatitis C: Clinical trials in patients with advanced chronic kidney disease
AbstractHepatitis C is a global health concern, with important implications in chronic kidney disease (CKD) due to its increased prevalence in this population. Patients with advanced CKD have until recently been excluded from the pivotal direct acting anti ‐viral(DAA) trials, which have demonstrated high virological cure numbers. Sofosbuvir ‐free DAAs dasabuvir, ombitasvir/paritaprevir/ritonavir with or without ribavirin, and elbasvir/grazoprevir are well‐tolerated in patients with genotype 1 and 4 CHC with CKD 4 or 5 (including HD), with virologic cure rates of above 90%, in both single‐arm and placebo‐controlle...
Source: Seminars In Dialysis - November 26, 2018 Category: Hematology Authors: Annette Bruchfeld, Karin Lindahl Tags: HEPATITIS C VIRUS INFECTION IN PATIENTS WITH KIDNEY DISEASE: A ROADMAP FOR NEPHROLOGISTS Source Type: research

Sympathetic overactivity in dialysis patients-Underappreciated and clinically consequential.
Abstract Cardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence-based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been established to be prognostic in the dialysis population for over 15 years. Despite this, tangible therapeutic interventions have, to date, been unsuccessful and the outlook for patients remains poor. This narrative review summarizes established experimental and clinical data, highlighting recen...
Source: Seminars in Dialysis - November 21, 2018 Category: Urology & Nephrology Authors: Hoye NA, Wilson LC, Jardine DL, Walker RJ Tags: Semin Dial Source Type: research

Sympathetic overactivity in dialysis patients —Underappreciated and clinically consequential
AbstractCardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence ‐based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been established to be prognostic in the dialysis population for over 15 years. Despite this, tangible therapeu tic interventions have, to date, been unsuccessful and the outlook for patients remains poor. This narrative review summarizes established experimental and clinical data, highlighting recent deve...
Source: Seminars In Dialysis - November 21, 2018 Category: Hematology Authors: Neil A. Hoye, Luke C. Wilson, David L. Jardine, Robert J. Walker Tags: REVIEW ARTICLE Source Type: research

Blood pressure target for the dialysis patient.
Abstract The appropriate blood pressure (BP) target for dialysis patients remains controversial. Although there have been remarkable advances in this area in the general population, extrapolation of these data to dialysis patients is not possible. Observational studies in dialysis patients suggest that low BP is associated with worse outcomes. However, this is likely a result of confounding, considering that among dialysis patients with fewer cardiovascular comorbidities and longer survival, a more linear relationship exists between BP and mortality. Use of home BP measurements and ambulatory blood pressure monito...
Source: Seminars in Dialysis - November 13, 2018 Category: Urology & Nephrology Authors: McCallum W, Sarnak MJ Tags: Semin Dial Source Type: research

Blood pressure target for the dialysis patient
AbstractThe appropriate blood pressure (BP) target for dialysis patients remains controversial. Although there have been remarkable advances in this area in the general population, extrapolation of these data to dialysis patients is not possible. Observational studies in dialysis patients suggest that low BP is associated with worse outcomes. However, this is likely a result of confounding, considering that among dialysis patients with fewer cardiovascular comorbidities and longer survival, a more linear relationship exists between BP and mortality. Use of home BP measurements and ambulatory blood pressure monitoring (ABPM...
Source: Seminars In Dialysis - November 13, 2018 Category: Hematology Authors: Wendy McCallum, Mark J. Sarnak Tags: REVIEW ARTICLE Source Type: research

Is successful treatment of depression in dialysis patients an achievable goal?
Abstract Depression is undisputedly common among individuals with End-Stage Kidney Failure and associated with adverse outcomes. It is well recognized that effective treatments for depression are needed within routine dialysis care. But, are we any closer to successfully treating depression in dialysis patients? We consider this question here with respect to two common treatments, antidepressant medication and cognitive behavioural therapy (CBT). Currently, there are limited data from randomized placebo-controlled trials regarding the acceptability and efficacy of antidepressants. CBT trials appear to show more co...
Source: Seminars in Dialysis - November 12, 2018 Category: Urology & Nephrology Authors: Chilcot J, Hudson JL Tags: Semin Dial Source Type: research

Is successful treatment of depression in dialysis patients an achievable goal?
AbstractDepression is undisputedly common among individuals with End ‐Stage Kidney Failure and associated with adverse outcomes. It is well recognized that effective treatments for depression are needed within routine dialysis care. But, are we any closer to successfully treating depression in dialysis patients? We consider this question here with respect to two co mmon treatments, antidepressant medication and cognitive behavioural therapy (CBT). Currently, there are limited data from randomized placebo‐controlled trials regarding the acceptability and efficacy of antidepressants. CBT trials appear to show more consis...
Source: Seminars In Dialysis - November 12, 2018 Category: Hematology Authors: Joseph Chilcot, Joanna L. Hudson Tags: EDITORIAL Source Type: research

Euvolemia-A critical target in the management of acute kidney injury.
Abstract It has been clearly established that critically ill patients with sepsis require prompt fluid resuscitation. The optimal amount of fluid and when to taper this resuscitation is less clear. There is a growing evidence that fluid overload leads to acute kidney injury, and increased morbidity and mortality. A clinician's best intentions in resuscitating a patient can lead to too much of a good thing. Currently, there are several bedside tools to aid in determining a patient's response to a fluid challenge as well as in the assessment of the current volume status. Guidelines are not available on the exact rat...
Source: Seminars in Dialysis - November 9, 2018 Category: Urology & Nephrology Authors: Colbert GB, Szerlip HM Tags: Semin Dial Source Type: research

Euvolemia —A critical target in the management of acute kidney injury
AbstractIt has been clearly established that critically ill patients with sepsis require prompt fluid resuscitation. The optimal amount of fluid and when to taper this resuscitation is less clear. There is a growing evidence that fluid overload leads to acute kidney injury, and increased morbidity and mortality. A clinician's best intentions in resuscitating a patient can lead to too much of a good thing. Currently, there are several bedside tools to aid in determining a patient's response to a fluid challenge as well as in the assessment of the current volume status. Guidelines are not available on the exact rate of fluid...
Source: Seminars In Dialysis - November 9, 2018 Category: Hematology Authors: Gates B. Colbert, Harold M. Szerlip Tags: EDITORIAL Source Type: research

Briefly Noted
Seminars in Dialysis, Volume 31, Issue 6, Page 637-638, November/December 2018. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - November 5, 2018 Category: Hematology Authors: Richard A. Sherman Tags: BRIEFLY NOTED Source Type: research

Issue Information
Seminars in Dialysis, Volume 31, Issue 6, Page 533-534, November/December 2018. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - November 5, 2018 Category: Hematology Tags: ISSUE INFORMATION Source Type: research

Introduction to treatment considerations in conventional hemodialysis ‐ What we know
Seminars in Dialysis, Volume 31, Issue 6, Page 535-536, November/December 2018. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - November 5, 2018 Category: Hematology Authors: Keiichi Sumida, Csaba P. Kovesdy Tags: GUEST EDITORS' COMMENTARY Source Type: research

Introduction to treatment considerations in conventional hemodialysis - What we know.
PMID: 30394604 [PubMed - in process] (Source: Seminars in Dialysis)
Source: Seminars in Dialysis - November 1, 2018 Category: Urology & Nephrology Authors: Sumida K, Kovesdy CP Tags: Semin Dial Source Type: research

Peritoneal dialysis has optimal intradialytic hemodynamics and preserves residual renal function: Why isn't it better than hemodialysis?
Abstract Rates of cardiovascular mortality are disproportionately high in patients with end stage kidney disease receiving dialysis. However, it is now generally accepted that patient survival is broadly equivalent between the two most frequently used forms of dialysis, in-center hemodialysis (HD) and peritoneal dialysis (PD). This equivalent patient survival is notable when considering how specific aspects of HD have been shown to contribute to morbidity and mortality. These include more rapid loss of residual renal function (RRF), HD-induced myocardial and cerebral ischemia, and risk factors associated with the ...
Source: Seminars in Dialysis - October 23, 2018 Category: Urology & Nephrology Authors: Selby NM, Kazmi I Tags: Semin Dial Source Type: research

Benefits, challenges, and opportunities using home hemodialysis with a focus on Mississippi, a rural southern state.
uml;p T Abstract The prevalence of end-stage renal disease continues to increase in the United States with commensurate need for renal replacement therapies. Hemodialysis continues to be the predominant modality, though less than 2% of these patients will receive hemodialysis in their own home. While home modalities utilizing peritoneal dialysis have been growing, home hemodialysis (HHD) remains underutilized despite studies showing regression in left ventricular mass, improved quality of life, reduced depressive symptoms, and decreased postdialysis recovery time. To increase penetration of HHD will require a proa...
Source: Seminars in Dialysis - October 23, 2018 Category: Urology & Nephrology Authors: Salim SA, Zsom L, Cheungpasitporn W, Fülöp T Tags: Semin Dial Source Type: research

Peritoneal dialysis has optimal intradialytic hemodynamics and preserves residual renal function: Why isn't it better than hemodialysis?
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - October 23, 2018 Category: Hematology Authors: Nicholas M. Selby, Isma Kazmi Source Type: research

Benefits, challenges, and opportunities using home hemodialysis with a focus on Mississippi, a rural southern state
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - October 23, 2018 Category: Hematology Authors: Sohail Abdul Salim, Lajos Zsom, Wisit Cheungpasitporn, Tibor F ülöp Source Type: research

Dialysate sodium concentration: The forgotten salt shaker.
This article presents a review of the clinical effects of DNa and of basic aspects of sodium balance in hemodialysis patients. PMID: 30343516 [PubMed - as supplied by publisher] (Source: Seminars in Dialysis)
Source: Seminars in Dialysis - October 21, 2018 Category: Urology & Nephrology Authors: Hanafusa N, Tsuchiya K, Nitta K Tags: Semin Dial Source Type: research

Dialysate sodium concentration: The forgotten salt shaker
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - October 21, 2018 Category: Hematology Authors: Norio Hanafusa, Ken Tsuchiya, Kosaku Nitta Source Type: research

Eliminating the need for routine monthly postdialysis serum urea nitrogen measurement: A method for monitoring Kt/V and normalized protein catabolic rate using conductivity determined dialyzer clearance
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - October 12, 2018 Category: Hematology Authors: John T. Daugirdas Source Type: research

Intradialytic alkalization affects calcium balance and PTH level
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - October 12, 2018 Category: Hematology Authors: Jan Havlin, Svetlana Vankova Source Type: research

Intradialytic alkalization affects calcium balance and PTH level.
PMID: 30311261 [PubMed - as supplied by publisher] (Source: Seminars in Dialysis)
Source: Seminars in Dialysis - October 11, 2018 Category: Urology & Nephrology Authors: Havlin J, Vankova S Tags: Semin Dial Source Type: research

Eliminating the need for routine monthly postdialysis serum urea nitrogen measurement: A method for monitoring Kt/V and normalized protein catabolic rate using conductivity determined dialyzer clearance.
Abstract Many dialysis machines can compute dialyzer sodium clearances at multiple time points during a dialysis treatment using conductivity. For a given treatment, the average dialyzer sodium clearance (K), when combined with treatment time (t), and the estimated urea distribution volume (V, usually based on either anthropometry or bioimpedance), can be used to estimate Kt/V, an important measure of hemodialysis adequacy. While this conductivity-derived value for Kt/V correlates moderately with Kt/V calculated from predialysis and postdialysis serum urea nitrogen (SUN) values (urea reduction ratio, URR), the ult...
Source: Seminars in Dialysis - October 11, 2018 Category: Urology & Nephrology Authors: Daugirdas JT Tags: Semin Dial Source Type: research

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - October 5, 2018 Category: Hematology Authors: Vassilios Liakopoulos, Stefanos Roumeliotis, Sotirios Zarogiannis, Theodoros Eleftheriadis, Peter R. Mertens Source Type: research

Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions.
Abstract Oxidative stress (OS) is the result of prooxidant molecules overwhelming the antioxidant defense mechanisms. Hemodialysis (HD) constitutes a state of elevated inflammation and OS, due to loss of antioxidants during dialysis and activation of white blood cells triggering production of reactive oxygen species. Dialysis vintage, dialysis methods, and type and condition of vascular access, biocompatibility of dialyzer membrane and dialysate, iron administration, and anemia all can play a role in aggravating OS, which in turn has been associated with increased morbidity and mortality. Oral or intravenous admin...
Source: Seminars in Dialysis - October 4, 2018 Category: Urology & Nephrology Authors: Liakopoulos V, Roumeliotis S, Zarogiannis S, Eleftheriadis T, Mertens PR Tags: Semin Dial Source Type: research

Conventional dialysis in the elderly: How lenient should our guidelines be?
Abstract There has been a dramatic, worldwide expansion in life expectancy across the last century. This has resulted in a progressively more elderly and comorbid population. It is increasingly recognized that healthcare in this group needs to move to the concept of "adding life to years". Recognition and assessment of frailty is vital in changing our approach in elderly patients. Current guidelines in dialysis have a limited evidence base across all age groups, but particularly the elderly and serve them poorly. Moreover, the burden of guidelines for each comorbidity of the multimorbid patient is increa...
Source: Seminars in Dialysis - September 21, 2018 Category: Urology & Nephrology Authors: Corbett RW, Brown EA Tags: Semin Dial Source Type: research

Conventional dialysis in the elderly: How lenient should our guidelines be?
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - September 21, 2018 Category: Hematology Authors: Richard W. Corbett , Edwina A. Brown Source Type: research

Issue Information
Seminars in Dialysis,Volume 31, Issue 5, Page 433-434, September/October 2018. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - September 3, 2018 Category: Hematology Source Type: research

Briefly Noted
Seminars in Dialysis,Volume 31, Issue 5, Page 530-531, September/October 2018. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - September 3, 2018 Category: Hematology Authors: Richard A. Sherman Source Type: research

PTH assays in dialysis patients: Practical considerations
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - August 31, 2018 Category: Hematology Authors: Mohanad Soliman , Waleed Hassan , Maria Yaseen , Madhumathi Rao , B. Peter Sawaya , Amr El ‐Husseini Source Type: research

PTH assays in dialysis patients: Practical considerations.
Abstract Parathyroid hormone (PTH) 1-84 is the main biologically active hormone produced by the parathyroid cells. Circulating PTH molecules include the whole PTH 1-84 along with amino (N) and carboxyl (C) terminal fragments. While PTH is the best available noninvasive biomarker to assess bone turnover in dialysis patients, the biological roles of individual circulating PTH fragments are still not completely known. The understanding that there is an enormous variation in the target specificity of currently available PTH assays for different circulating forms of PTH has led to the evolution of assays from first to ...
Source: Seminars in Dialysis - August 30, 2018 Category: Urology & Nephrology Authors: Soliman M, Hassan W, Yaseen M, Rao M, Sawaya BP, El-Husseini A Tags: Semin Dial Source Type: research

Boundaries of frequency and treatment time in conventional hemodialysis: Balancing convenience, economics, and health outcomes
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - August 10, 2018 Category: Hematology Authors: Clare B. Jones , Christopher T. Chan Source Type: research

Boundaries of frequency and treatment time in conventional hemodialysis: Balancing convenience, economics, and health outcomes.
Abstract Since the inception of hemodialysis (HD) for patients with chronic kidney disease, the "perfect" dialysis prescription has remained elusive. Part of this may relate to the heterogeneity among populations, individual patients, and differences in access to health provision. The optimal balance between dialysis frequency and duration to achieve reductions in patient morbidity and mortality continues to be debated. The concept of dialysis adequacy originated from a post hoc mathematical analysis of the National Cooperative Study and has evolved to become a way of calculating dialysis dose and standa...
Source: Seminars in Dialysis - August 9, 2018 Category: Urology & Nephrology Authors: Jones CB, Chan CT Tags: Semin Dial Source Type: research

Blood pressure control in conventional hemodialysis
Seminars in Dialysis, EarlyView. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - August 7, 2018 Category: Hematology Authors: Panagiotis I. Georgianos , Rajiv Agarwal Source Type: research