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Specialty: Hematology
Condition: Ischemic Stroke

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Total 1017 results found since Jan 2013.

Cancer and stroke: What do we know and where do we go?
Cancer is an increasingly recognized cause for ischemic stroke, with recent acknowledgement of cancer-related stroke as an emerging stroke subtype with unique pathophysiologic mechanisms. In addition, cancer-related stroke may differ from stroke in the general population as cancer patients may not receive guideline-recommended stroke care, and the occurrence of stroke may also preclude patients from receiving optimal cancer treatments. Due to the high degree of morbidity and mortality associated with both conditions, understanding the relationship between stroke and cancer is crucial.
Source: Thrombosis Research - September 16, 2022 Category: Hematology Authors: Ronda Lun, Deborah Siegal, Tim Ramsay, Dar Dowlatshahi Source Type: research

The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its aetiology, severity and prognosis
CONCLUSIONS: The use of the SWATH-MS in thrombi from IS patients has provided new insights of pathways and players involved in its aetiology, severity and prognosis. The prominent role of the innate immune system identified might pave the way for the development of new biomarkers and therapeutic approaches in this disease.PMID:37100394 | DOI:10.1016/j.jtha.2023.04.015
Source: Thrombosis and Haemostasis - April 26, 2023 Category: Hematology Authors: Chary Lopez-Pedrera Rafael Oteros Alejandro Ib áñez-Costa Mar ía Luque-Tévar Laura Mu ñoz-Barrera Nuria Barbarroja Eduardo Chicano-G álvez Juan Marta-Enguita Josune Orbe Francisco Velasco Carlos Perez-S ánchez Source Type: research

Stroke and dyslipidaemia in Africa: a meta-analysis of case-control studies
Conclusion: Although not particularly substantial, there is an association between dyslipidaemia and stroke in Africa.
Source: Journal of Thrombosis and Thrombolysis - May 6, 2023 Category: Hematology Source Type: research

Differential impact of unrecognised brain infarction on stroke outcome in non-valvular atrial fibrillation.
This study enrolled 631 patients with NVAF having no clinical stroke history. UBIs were categorised into three types as territorial, lacunar, or subcortical. We collected stroke severity, functional outcome at three months, and the total volume of UBIs and acute infarction lesions. We investigated the association between clinical outcome and the type or volume of UBI, using a linear mixed model and logistic regression analysis. UBIs were detected in 285 (45.2 %) patients; territorial UBIs were observed in 24.4 % of patients (154/631), lacunar UBIs in 25 % (158/631), and subcortical UBIs in 15.7 % (99/631). Although...
Source: Thrombosis and Haemostasis - September 18, 2014 Category: Hematology Authors: Song TJ, Kim J, Lee HS, Nam CM, Nam HS, Kim EH, Lee KJ, Song D, Heo JH, Kim YD Tags: Thromb Haemost Source Type: research

Pretreatment with rivaroxaban attenuates stroke severity in rats by a dual antithrombotic and anti-inflammatory mechanism.
This study examined whether prestroke anticoagulation with rivaroxaban, a novel direct factor Xa inhibitor, influences stroke severity, thrombin-mediated intracerebral thrombus formation and pro-inflammatory processes in a rat model of brain ischaemia/reperfusion injury. Male Wistar rats were anticoagulated with rivaroxaban and subjected to 90 minutes of transient middle cerebral artery occlusion. Infarct size, functional outcome and the occurrence of intracranial haemorrhage (ICH) were assessed until day 7. Thrombin generation was determined by measuring the amount of thrombin/antithrombin complex. Intracerebral thrombus ...
Source: Thrombosis and Haemostasis - October 22, 2015 Category: Hematology Authors: Dittmeier M, Kraft P, Schuhmann MK, Fluri F, Kleinschnitz C Tags: Thromb Haemost Source Type: research

The VWF-GPIb axis in ischaemic stroke: lessons from animal models.
Abstract Stroke is a leading cause of death and long-term disability worldwide. Ischaemic stroke is caused by a blood clot that obstructs cerebral blood flow. Current treatment mainly consists of achieving fast reperfusion, either via pharmacological thrombolysis using tissue plasminogen activator or via endovascular thrombectomy. Unfortunately, reperfusion therapy is only available to a limited group of patients and reperfusion injury can further aggravate brain damage. Hence, there is an urgent need for better understanding of ischaemic stroke pathophysiology in order to develop novel therapeutic strategies. In ...
Source: Thrombosis and Haemostasis - March 30, 2016 Category: Hematology Authors: Denorme F, De Meyer SF Tags: Thromb Haemost Source Type: research

Spotlight on unmet needs in stroke prevention: The PIONEER AF-PCI, NAVIGATE ESUS and GALILEO trials.
This article focuses on three randomised controlled trials (RCTs) that are investigating the utility of rivaroxaban, a direct, oral, factor Xa inhibitor, in additional areas of stroke prevention where data for anticoagulants are lacking: oPen-label, randomized, controlled, multicentre study explorIng twO treatmeNt stratEgiEs of Rivaroxaban and a dose-adjusted oral vitamin K antagonist treatment (PIONEER AF-PCI); New Approach riVaroxoban Inhibition of factor Xa in a Global trial vs Aspirin to prevenT Embolism in Embolic Stroke of Undetermined Source (NAVIGATE ESUS); and Global study comparing a rivAroxaban-based antithrombo...
Source: Thrombosis and Haemostasis - September 13, 2016 Category: Hematology Authors: Hemmrich M, Peterson ED, Thomitzek K, Weitz JI Tags: Thromb Haemost Source Type: research

Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study
ConclusionsHigher FIX antigen was associated with incident CHD in blacks but not whites. FIX levels may increase CHD risk among blacks.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 10, 2017 Category: Hematology Authors: N.C. Olson, M. Cushman, S.E. Judd, B.M. Kissela, M.M. Safford, G. Howard, N.A. Zakai Tags: Original Article ‐ Coagulation Source Type: research

Relation of coagulation factor XI with incident coronary heart disease and stroke: the Cardiovascular Health Study
We examined the association of FXI with incident coronary heart disease (CHD), ischemic stroke, and hemorrhagic stroke. Data were from 3394 adults (mean age: 74.5 years) enrolled in the Cardiovascular Health Study who had FXI antigen from plasma samples drawn in 1992–1993 and were followed for cardiovascular events until 30 June 2013. Approximately 63% of participants were women and 17% were black. FXI levels were higher in blacks and women, showed positive associations with high-density lipoprotein and total cholesterol, BMI and diabetes, and negative associations with age and alcohol intake. During median follow-up of ...
Source: Blood Coagulation and Fibrinolysis - July 1, 2017 Category: Hematology Tags: Original Articles Source Type: research

Number of ischemic strokes potentially eligible for revascularization treatments in an Italian Comprehensive Stroke Center: a modeling study
AbstractTo rationally plan acute services, the proportion of ischemic strokes that may be eligible for revascularization treatments should be estimated. We aimed to estimate the proportion of patients directly admitted to an Italian Comprehensive Stroke Center who may be eligible for intravenous thrombolysis (IVT), combined IVT and endovascular thrombectomy (ET), or direct ET according to the current guidelines. We conducted a retrospective analysis based on data prospectively collected from 876 consecutive adult ischemic stroke patients who were directly admitted to the Stroke Unit of the University Hospital of Verona wit...
Source: Journal of Thrombosis and Thrombolysis - July 14, 2018 Category: Hematology Source Type: research

Stroke Severity in Patients on Non-Vitamin K Antagonist Oral Anticoagulants with a Standard or Insufficient Dose.
CONCLUSION:  Use of warfarin with a therapeutic intensity or standard-dosed NOACs was associated with a relatively mild stroke in the patients with NVAF. PMID: 30453351 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 19, 2018 Category: Hematology Authors: Jung YH, Choi HY, Lee KY, Cheon K, Han SW, Park JH, Cho HJ, Park HJ, Nam HS, Heo JH, Lee HS, Kim YD Tags: Thromb Haemost Source Type: research

“Blueprinting” thrombogenicity and antithrombotic drug response at the bedside in patients presenting emergently with symptoms of acute stroke
AbstractEarly assessment of thrombogenicity and antithrombotic drug effects may be important for therapeutic decision making in patients presenting with acute stroke. In this prospective, single center, pilot study, a bedside thrombelastography assay (TEG6s) was used to measure thrombogenicity and antithrombotic drug response in serial patients presenting emergently with symptoms of acute stroke (n  = 90). TEG6s measures were compared against diagnosis obtained by NIH Stroke Scale/Score and imaging. Acute ischemic stroke (AIS) was diagnosed in 30 patients, intracerebral hemorrhage (ICH) in 19, transient ischemic attack...
Source: Journal of Thrombosis and Thrombolysis - January 23, 2019 Category: Hematology Source Type: research

Characterisation of acute ischemic stroke in patients with left ventricular thrombi after myocardial infarction
AbstractAcute ischemic stroke (AIS) is a feared complication in post-acute myocardial infarction (AMI) patients who develop left ventricular (LV) thrombus. There is limited data available on the incidence of stroke in this population, and characterisation of stroke subtypes has not been previously reported. Our study aims to evaluate the incidence of AIS in post-AMI patients with LV thrombus and to characterise the pattern of stroke subtypes. We screened 5829 patients with echocardiogram reports containing the “thrombus” keyword from August 2006 to September 2017. AIS that occurred after LV thrombosis was captured and ...
Source: Journal of Thrombosis and Thrombolysis - February 25, 2019 Category: Hematology Source Type: research

Pediatric Stroke: A Single-Center Experience
The aim of this study was to evaluate the clinical characteristics, risk factors, treatment, and outcomes of pediatric stroke cases. A total of 118 patients diagnosed with arterial ischemic stroke (AIS), hemorrhagic stroke, and sinovenous thrombosis (SVT) between January 2000 and December 2011 were included. Neonatal cases were excluded. Demographic and clinical findings were retrospectively examined from medical records. We identified 118 patients with stroke. The age of the patients ranged from 1 to 215 months (17.92 y), with a mean age of 5.19±5.25 years. AIS accounted for the majority of cases (n=69, 58.5%), and the...
Source: Journal of Pediatric Hematology Oncology - September 30, 2019 Category: Hematology Tags: Original Articles Source Type: research