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Intravenous Thrombolysis Resulting In Acute Ischemic Stroke Recanalization Can Lead To Cerebral Hyperperfusion Syndrome (P7.123)
Conclusion- Cerebral hyperperfusion syndrome after intravenous thrombolysis in acute ischemic stroke should be suspected in patients that achieve arterial recanalization and develop unexplained new neuropsychiatric manifestations.Disclosure: Dr. Ong has nothing to disclose. Dr. Yeo has nothing to disclose. Dr. Ting has nothing to disclose. Dr. Sinha has nothing to disclose. Dr. Teoh has nothing to disclose. Dr. Chan has nothing to disclose. Dr. Seet has nothing to disclose. Dr. Sharma has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ong, J., Yeo, L., Ting, E., Sinha, A., Teoh, H. L., Chan, B., Seet, C. S., Sharma, V. Tags: Cerebrovascular Disease and Interventional Neurology: Issues in Acute Stroke Treatment Source Type: research

Acute prolonged motor aura resembling ischemic stroke after COVID − 19 vaccination (CoronaVac): the first case report
In this study, we present the first case of stroke mimic after CoronaVac vaccination. After negative imaging studies had been performed repeatedly, we reach a conclusion that stroke is unlikely to be the cause. Presumably, this phenomenon could possibly have abnormal functional imaging study. Therefore, we believed that it might be due to cortical spreading depression, like migraine aura, which we had conducted a literature review.
Source: The Journal of Headache and Pain - August 12, 2021 Category: Neurology Source Type: research

Pathological generosity: An atypical impulse control disorder after a left subcortical stroke.
We report on a case of pathological generosity secondary to a left lenticulocapsular stroke with hypoperfusion of several anatomically intact cortical areas. A 49-year-old man developed excessive and persistent generosity as he recovered from a left lenticulocapsular hematoma. His symptoms resembled an impulse control disorder. (99m)Tc-HMPAO SPECT demonstrated hypoperfusion mostly in the ipsilateral striatum, dorsolateral, and orbitofrontal cortex. This case study adds pathological generosity to the range of behavioral changes that may result from discrete unilateral lesions of the lenticular nucleus and nearby pathways. I...
Source: Neurocase - August 20, 2013 Category: Neurology Authors: Ferreira-Garcia R, Fontenelle LF, Moll J, de Oliveira-Souza R Tags: Neurocase Source Type: research

Depressive symptoms, atherosclerotic burden and cerebral blood flow disturbances in a cohort of octogenarian men from a general population
Conclusion: In this population-based cohort of octogenarian men free from stroke or dementia, a proportion of subjects with depressive symptoms was low. Still, men with borderline or mild depression scores had lower social and physical activity, persistent smoking habit, worse peripheral circulation in legs, and cerebral perfusion changes in basal nuclei, thalamus and subcortical white matter. Regional CBF decline could be partly mediated by higher SBP.
Source: BMC Psychiatry - Latest articles - December 26, 2013 Category: Psychiatry Authors: Arkadiusz Siennicki-LantzLena André-PeterssonPer WollmerSölve Elmståhl Source Type: research

Migrainous Infarction in a Patient With Sporadic Hemiplegic Migraine and Cystic Fibrosis: A 99mTc-HMPAO Brain SPECT Study.
We describe the case of a patient with CF, who had a migrainous stroke during an SHM attack. A 32-year-old Caucasian male was diagnosed with CF, with heterozygotic delta F508/unknown CFTR mutation. The patient experiences bouts of coughing sometimes triggering SHM attacks with visual phosphenes, aphasia, right-sided paresthesia, and hemiparesis. He had a 48-hour hemiparesis triggered by a bout of coughing with hemoptysis, loss of consciousness, and severe hypoxia-hypercapnia. MRI demonstrated transient diffusion hyperintensity in the left frontal-parietal-occipital regions resulting in a permanent infarction in the primary...
Source: Headache - January 8, 2019 Category: Neurology Authors: Mancini V, Mastria G, Frantellizzi V, Troiani P, Zampatti S, Carboni S, Giardina E, Campopiano R, Gambardella S, Turchi F, Petolicchio B, Toscano M, Liberatore M, Viganò A, Di Piero V Tags: Headache Source Type: research

Effects of Surgical Revascularization on Cerebral Oxygen Metabolism in Patients With Moyamoya Disease: An 15O-Gas Positron Emission Tomographic Study Clinical Sciences
Conclusions— Cerebral oxygen metabolism is significantly depressed in 80% of the involved hemispheres of moyamoya disease and improves in pediatric and younger adult patients without parenchymal lesions after bypass surgery. Cerebral oxygen metabolism may be reversibly depressed in response to cerebral ischemia in them although the underlying mechanisms are still unclear.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Kuroda, S., Kashiwazaki, D., Hirata, K., Shiga, T., Houkin, K., Tamaki, N. Tags: Secondary prevention, PET and SPECT, By-pass procedures Clinical Sciences Source Type: research

SPECT Perfusion Imaging Demonstrates Improvement of Traumatic Brain Injury With Transcranial Near-infrared Laser Phototherapy.
Authors: Henderson TA, Morries LD Abstract Traumatic brain injury (TBI) is a growing health concern affecting civilians and military personnel. Near-infrared (NIR) light has shown benefits in animal models and human trials for stroke and in animal models for TBI. Diodes emitting low-level NIR often have lacked therapeutic efficacy, perhaps failing to deliver sufficient radiant energy to the necessary depth. In this case report, a patient with moderate TBI documented in anatomical magnetic resonance imaging (MRI) and perfusion single-photon emission computed tomography (SPECT) received 20 NIR treatments in the cours...
Source: Advances in Mind Body Medicine - November 7, 2015 Category: Psychiatry Tags: Adv Mind Body Med Source Type: research

Translocator protein and new targets for neuroinflammation
Abstract The mitochondrial translocator protein (18 kDa; TSPO) is involved in a wide array of physiological processes importantly including cholesterol transport, steroidogenesis and immunomodulation. In the central nervous system (CNS), TSPO expression regionally increases in glial cells upon brain insult with a differential pattern suggestive of cell-specific functions in inflammation and repair. These properties have made TSPO a valuable marker to assess the state, and progression of diverse neurological and psychiatric conditions, including traumatic brain injury, stroke, neurodegenerative diseases, anxiety, ...
Source: Clinical and Translational Imaging - November 16, 2015 Category: Radiology Source Type: research

Endothelial Dysfunction and Platelet Activation in Major Depressive Disorder: Association with Brain Perfusion Abnormalities
Conclusions: Our data confirmed increased rates of endothelial damage and platelet activation in non-treated MDD patients. Furthermore, we found a positive association between regional brain perfusion and platelet activation. Together, our observations showed impairment of two fundamental hemostatic components, platelets and endothelial cells, in MDD patients, which may explain not only the increased risk of systemic vascular complications but also the association with the brain vasculature. These findings may allow to explore new treatments aimed at protecting the endothelium and targeting platelet activation, as a compre...
Source: Blood - November 21, 2018 Category: Hematology Authors: Pereira, J., Massardo, T., Saez, C. G., Olivares, N., Valenzuela, J. G., Risco, L., Veliz, J., Spuler, J., Castro, G., Falloux, E., Villa, C., Quintana, J. C., Vicentini, D., Mezzano, D. Tags: 301. Vascular Wall Biology, Endothelial Progenitor Cells, and Platelet Adhesion, Activation, and Biochemistry Source Type: research

Molecules, Vol. 25, Pages 4749: A Review of Molecular Imaging of Glutamate Receptors
umming Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) is a well-established and important in vivo technique to evaluate fundamental biological processes and unravel the role of neurotransmitter receptors in various neuropsychiatric disorders. Specific ligands are available for PET/SPECT studies of dopamine, serotonin, and opiate receptors, but corresponding development of radiotracers for receptors of glutamate, the main excitatory neurotransmitter in mammalian brain, has lagged behind. This state of affairs has persisted despite the central importance o...
Source: Molecules - October 16, 2020 Category: Chemistry Authors: Jong-Hoon Kim J ános Marton Simon Mensah Ametamey Paul Cumming Tags: Review Source Type: research