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Experimental Cardiac Radiation Exposure Induces Ventricular Diastolic Dysfunction with Preserved Ejection Fraction.
CONCLUSION: Experimental cardiac radiation exposure resulted in diastolic dysfunction without reduced EF. These data provide insight into the association between cardiac radiation exposure and HFpEF risk and lend further support for the importance of inflammation related coronary microvascular compromise in HFpEF. PMID: 28550173 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 26, 2017 Category: Physiology Authors: Saiki H, Moulay G, Guenzel AJ, Liu W, Decklever T, Classic K, Pham L, Chen HH, Burnett JC, Russell SJ, Redfield MM Tags: Am J Physiol Heart Circ Physiol Source Type: research

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction
Breast cancer radiotherapy increases the risk of heart failure with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radioresistant, but radiation specifically affects coronary microvascular endothelial cells, with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF. Global cardiac expression of the sodium-iodide symporter (NIS) was induced by cardiotropic gene (adeno-associated virus serotype 9) delivery to 5-w...
Source: AJP: Heart and Circulatory Physiology - August 11, 2017 Category: Cardiology Authors: Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C., Russell, S. J., Redfield, M. M. Tags: RESEARCH ARTICLE Source Type: research

Role of Gallium-SPECT-CT in the Management of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
Implantable left ventricular assist device (LVAD) has dramatically improved the prognosis of patients with advanced heart failure.1 With ongoing technological innovation, patient survival and quality of life are further improving,2,3 and major complications related to LVAD such as pump thrombosis and stroke have decreased3; however, these complications have not been completely overcome. Infection remains a major complication in up to 60% of VAD patients and worsens prognosis and quality of life.
Source: Journal of Cardiac Failure - August 23, 2019 Category: Cardiology Authors: Yuki Kimura, Osamu Seguchi, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Kensuke Kuroda, Seiko Nakajima, Emi Tateishi, Takuya Watanabe, Yorihiko Matsumoto, Satsuki Fukushima, Keisuke Kiso, Masanobu Yanase, Tomoyuki Fujita, Junjiro Kobayas Source Type: research

Prognostic value of 99m Tc-ECD brain perfusion SPECT in patients with atrial fibrillation and dementia
ConclusionThis study demonstrated that decreased cerebral blood flow in the temporo-parieto-occipital lobe could be a potential prognostic value in patients with both AF and dementia.
Source: EJNMMI Research - January 9, 2020 Category: Radiology Source Type: research

Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive coronary artery disease (INOCA)
ConclusionsD-SPECT MPI provides excellent prognostic information, with a more severe prognosis in patients with abnormal D-SPECT MPI. INOCA patients with abnormal D-SPECT MPI experience a poor prognosis similar to that of patients with obstructive CAD.
Source: Journal of Nuclear Cardiology - September 29, 2020 Category: Nuclear Medicine Source Type: research

Left ventricular concentric remodeling and impaired cardiorespiratory fitness in patients with heart failure and preserved ejection fraction.
CONCLUSIONS: Post-exercise reduced LV volumes correlate with measures of impaired CRF in patients with HFpEF, thus supporting a pathophysiologic role of concentric remodeling in impaired CRF in HFpEF. PMID: 32996304 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - October 2, 2020 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA
ConclusioncaIMR-derived CMD is associated with increased risk of MACE among INOCA patients. Patients with abnormalities on both caIMR and MPI had the worse outcomes.Graphical abstract
Source: Journal of Nuclear Cardiology - August 2, 2022 Category: Nuclear Medicine Source Type: research

The prognostic value of CZT SPECT myocardial blood flow (MBF) quantification in patients with ischemia and no obstructive coronary artery disease (INOCA): a pilot study
ConclusionThe preliminary results demonstrated that quantitative analysis on CZT SPECT provides prognostic value for INOCA patients, which may allow the stratification for early prevention and intervention.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 14, 2023 Category: Nuclear Medicine Source Type: research