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The impact of inspiratory pressure on stroke volume variation and the evaluation of indexing stroke volume variation to inspiratory pressure under various preload conditions in experimental animals
Conclusions PIP is significantly correlated with SVV, even under hypovolemia, and the effect is enhanced with decreasing preload volumes. Compared with SVV, the indexed SVV was less susceptible to higher inspiratory pressures.
Source: Journal of Anesthesia - March 15, 2015 Category: Anesthesiology Source Type: research

Intra-Arterial Therapy for Acute Ischemic Stroke: a Golden Age
Opinion statement With the recent publication of multiple trials demonstrating the superiority of the endovascular treatment of patients presenting with stroke from large vessel occlusion (LVO) over medical management, the emergent care of these patients is entering a new era. This realization justifies an aggressive treatment approach with these stroke patients, given the poor natural history of the disease. In general, treatment should occur as quickly as is reasonably possible. Patients with NIHSS >8 should be considered, and if <6 h from onset imaging selection achieved with CT and CTA. Those with ASPE...
Source: Current Treatment Options in Neurology - May 18, 2015 Category: Neurology Source Type: research

Does intravenous atropine affect stroke volume variation in man?
CONCLUSION: Administration of intravenous atropine did not change SVV, and we present this as a novel finding. PMID: 26205325 [PubMed - as supplied by publisher]
Source: Acta Anaesthesiologica Taiwanica - July 20, 2015 Category: Anesthesiology Authors: Wajima Z, Shiga T, Imanaga K Tags: Acta Anaesthesiol Taiwan Source Type: research

P-008 on intent to treat adapt technique for 201 cases of anterior circulation acute ischemic stroke
We report our single center experience results of endovascular treatment of anterior circulation of ischemic stroke by the technique of direct aspiration.MethodsBetween September 2013 to March 2015 we reviewed the data of 201 patients presenting with large vessels anterior circulation occlusion for which the ADAPT technique was utilized in first intention and was associated with stentriever technique when necessary. Procedural and clinical data were collected for analysis. An univariate analysis of the following factors: Age, prior antiplatelet or anticoagulative therapy, localisation of the occlusion, an intravenous throm...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Blanc, R., Redjem, H., Bartolini, B., Ciccio, G., Smajda, S., Taylor, G., Lamrabet, S., Paraschakis, P., Piotin, M. Tags: SNIS 12th Annual Meeting Oral Poster Abstracts Source Type: research

Noninvasive pulse pressure variation and stroke volume variation to predict fluid responsiveness at multiple thresholds: a prospective observational study.
CONCLUSION: Noninvasive PPV and SVV measurements allow an acceptable FR prediction, although the reliability of both variables is dependent on the intended increase in SVI, which improves substantially with concomitant smaller grey zones at higher ↑SVI thresholds. PMID: 26335905 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - September 3, 2015 Category: Anesthesiology Authors: Vos JJ, Poterman M, Salm PP, Van Amsterdam K, Struys MM, Scheeren TW, Kalmar AF Tags: Can J Anaesth Source Type: research

The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output RESEARCH ARTICLE
Morten Smerup, Mads Damkjaer, Emil Brondum, Ulrik T. Baandrup, Steen Buus Kristiansen, Hans Nygaard, Christian Aalkjaer, Cathrine Sauer, Rasmus Buchanan, Mads Frost Bertelsen, Kristine Ostergaard, Carsten Grondahl, Geoffrey Candy, J. Michael Hasenkam, Niels H. Secher, Peter Bie, and Tobias WangGiraffes – the tallest extant animals on Earth – are renowned for their high central arterial blood pressure, which is necessary to secure brain perfusion. The pressure which may exceed 300 mmHg has historically been attributed to an exceptionally large heart. Recently, this has been refuted by several studies demonstrati...
Source: Journal of Experimental Biology - December 7, 2015 Category: Biology Authors: Smerup, M., Damkjaer, M., Brondum, E., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Aalkjaer, C., Sauer, C., Buchanan, R., Bertelsen, M. F., Ostergaard, K., Grondahl, C., Candy, G., Hasenkam, J. M., Secher, N. H., Bie, P., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Usefulness of stroke volume variation to assess blood volume during blood removal for autologous blood transfusion in pediatric patients.
CONCLUSION: Stroke volume variation obtained from the FloTrac/Vigileo(TM) monitoring system revealed a strong correlation with EBV during ANH without surgical stimulation. The usefulness of this device as an indicator of cardiac preload under hypovolemic or normovolemic conditions in children during surgery remains to be determined. PMID: 26749310 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - January 7, 2016 Category: Anesthesiology Authors: Tadokoro T, Kakinohana M, Fukumoto C, Kawabata T, Yoza K Tags: Paediatr Anaesth Source Type: research

Epidural Electrical Stimulation for Stroke Rehabilitation: Results of the Prospective, Multicenter, Randomized, Single-Blinded Everest Trial
Conclusions. The primary analysis pertaining to efficacy of EECS during upper limb motor rehabilitation in chronic stroke patients was negative at 4 weeks postrehabilitation. A better treatment response was observed in a subset of patients eliciting stimulation induced upper limb movements during motor threshold assessments performed prior to each rehabilitation session. Post hoc comparisons indicated treatment effect differences at 24 weeks, with the control group showing significant decline in the combined primary outcome measure relative to the investigational group. These results have the potential to inform future chr...
Source: Neurorehabilitation and Neural Repair - January 27, 2016 Category: Neurology Authors: Levy, R. M., Harvey, R. L., Kissela, B. M., Winstein, C. J., Lutsep, H. L., Parrish, T. B., Cramer, S. C., Venkatesan, L. Tags: Clinical Research Articles Source Type: research

The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output RESEARCH ARTICLE
Morten Smerup, Mads Damkjaer, Emil Brondum, Ulrik T. Baandrup, Steen Buus Kristiansen, Hans Nygaard, Jonas Funder, Christian Aalkjaer, Cathrine Sauer, Rasmus Buchanan, Mads Frost Bertelsen, Kristine Ostergaard, Carsten Grondahl, Geoffrey Candy, J. Michael Hasenkam, Niels H. Secher, Peter Bie, and Tobias Wang Giraffes – the tallest extant animals on Earth – are renowned for their high central arterial blood pressure, which is necessary to secure brain perfusion. Arterial pressure may exceed 300 mmHg and has historically been attributed to an exceptionally large heart. Recently, this has been refuted by seve...
Source: Journal of Experimental Biology - February 3, 2016 Category: Biology Authors: Smerup, M., Damkjaer, M., Brondum, E., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Funder, J., Aalkjaer, C., Sauer, C., Buchanan, R., Bertelsen, M. F., Ostergaard, K., Grondahl, C., Candy, G., Hasenkam, J. M., Secher, N. H., Bie, P., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Effect of fluid loading with normal saline and 6% hydroxyethyl starch on stroke volume variability and left ventricular volume
Conclusion: Administration of colloid and crystalloid induced similar responses in SVV. A higher plasma-expanding effect of HES compared to normal saline was demonstrated by the significant increase in LVEDV.Keywords: colloid–crystalloid controversy, fluid responsiveness, three-dimensional transesophageal echocardiography (3D-TEE)
Source: International Journal of General Medicine - September 29, 2015 Category: Journals (General) Tags: International Journal of General Medicine Source Type: research

In vivo bioimpedance changes during haemorrhagic and ischaemic stroke in rats: towards 3D stroke imaging using electrical impedance tomography
Electrical impedance tomography (EIT) could be used as a portable non-invasive means to image the development of ischaemic stroke or haemorrhage. The purpose of this study was to examine if this was possible using time difference imaging, in the anesthetised rat using 40 spring-loaded scalp electrodes with applied constant currents of 50–150 μ A at 2 kHz. Impedance changes in the largest 10% of electrode combinations were  −12.8%  ±  12.0% over the first 10 min for haemorrhage and  +46.1%  ±  37.2% over one hour for ischaemic stroke (mean  ±  SD, n   =  7 in each gro...
Source: Physiological Measurement - May 18, 2016 Category: Physiology Authors: T Dowrick, C Blochet and D Holder Source Type: research

From preoperative evaluation to stroke center: Management of postoperative acute ischemic stroke
This article reviews the perioperative management (covering diagnosis and treatment), prevention (covering surgery postponement, management with anticoagulant/antiplatelet and the growing interest in statins and beta-blockers) and intraoperative recommendations (covering anaesthetic techniques, ventilation strategies, transfusion and blood pressure management) specifically for the general surgical population. A summary of current treatments is enlightened by recently described evidence for the effectiveness of mechanical thrombectomy.
Source: Anaesthesia, Critical Care and Pain Medicine - May 31, 2016 Category: Anesthesiology Source Type: research

The Anesthetic Management of Interventional Procedures for Acute Ischemic Stroke
Abstract Acute ischemic stroke is a medical emergency. Expedient reperfusion is a key component of treatment and improves the odds for a good outcome. Anesthesiologists play an important role in the peri-procedural management of cerebral revascularization procedures in patients with acute ischemic stroke. We review critical concepts and provide evidence-based recommendations, when available, for the management of patients having angiographic procedures to treat acute ischemic stroke.
Source: Current Anesthesiology Reports - June 29, 2016 Category: Anesthesiology Source Type: research

Chapter 66 Endovascular treatment of acute ischemic stroke
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 136 Author(s): Thabele Leslie-Mazwi, James Rabinov, Joshua A. Hirsch Endovascular thrombectomy is an effective treatment for major acute ischemic stroke syndromes caused by major anterior circulation artery occlusions (commonly referred to as large vessel occlusion) and is superior to intravenous thrombolysis and medical management. Treatment should occur as quickly as is reasonably possible. All patients with moderate to severe symptoms (National Institutes of Health stroke scale &gt;8) and a treatable occlusion should be considered. The use of ...
Source: Handbook of Clinical Neurology - July 16, 2016 Category: Neurology Source Type: research