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Close monitoring for heart risk needed if breast, prostate cancer treatment includes hormones
(American Heart Association) Patients with breast and prostate cancers who are treated with hormonal therapies have an increased risk of heart attack and/or stroke as they age.The increased likelihood of a heart attack or stroke is greater in patients who already have two or more cardiovascular risk factors such as high blood pressure, high cholesterol, obesity, smoking or a family history of heart disease or stroke.The longer the duration of hormonal therapy, the higher the risk of cardiovascular disease.
Source: EurekAlert! - Medicine and Health - April 26, 2021 Category: International Medicine & Public Health Source Type: news

Co-morbidities in a Retrospective Cohort of Prostate Cancer Patients.
Conclusion: Better chronic disease management is needed among prostate cancer survivors through more effective survivorship care planning and interventions that promote health behaviors. PMID: 32269460 [PubMed - in process]
Source: Ethnicity and Disease - April 11, 2020 Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

How Might Bromodomain and Extra-Terminal (BET) Inhibitors Operate in Cardiovascular Disease?
AbstractBromodomain and extra-terminal (BET) inhibitors, acting via epigenetic mechanisms, have been developed recently as potential new treatments for cancer, including prostate cancer, and inflammatory conditions. Some BET inhibitors, such as RVX-208, also raise high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 levels. A recent meta-analysis of three small trials (n = 798) found that RVX-208 protected against major adverse cardiovascular events (MACE), raising the question as to whether this protective effect was an artefact, a chance finding, or mediated by HDL-C, anti-inflammatory pathways, or oth...
Source: American Journal of Cardiovascular Drugs - January 29, 2019 Category: Cardiology Source Type: research

Nine Easy Ways to Gain Control of Your Health in Your Forties
What lifestyle changes should you make to stay healthy through your 40s? originally appeared on Quora - the knowledge sharing network where compelling questions are answered by people with unique insights. Answer by Keck Medicine of USC, 500+ internationally renowned doctors at a leading academic medical center, on Quora: Getting older has its perks. Chances are you're more confident, have more direction and a defined sense of self. While your health is likely not a primary concern, it's important to take steps now to stop subtle changes before they become major health issues. Your 40s is the decade that your habits sta...
Source: Healthy Living - The Huffington Post - January 9, 2017 Category: Consumer Health News Source Type: news

Behind the Headlines 2016 Quiz of the Year
In 2014, Behind the Headlines has covered more than 500 health stories that made it into the mainstream media. If you've been paying attention you should find this quiz easy and fun. Why not test your knowledge of 2014's health news with our month-by-month quiz? Answers are at the foot of the page (no peeking!).   In January 2016's health news... In a controversial study, monkeys were genetically engineered to develop what disorder? 1) Sex addiction 2) Bi-polar disorder 3) Autism In a similarly controversial study, what psychological condition was dismissed as a "myth" 1) Seasonal affective disorder...
Source: NHS News Feed - December 5, 2016 Category: Consumer Health News Tags: Special reports Source Type: news

Statin Drugs and Prostate Cancer
Statin drugs are a group of widely prescribed ones used to lower a person's cholesterol level. Common statin medications include brands such as Lipitor, Crestor and Zocar. Statins work by inhibiting an enzyme in the human body, 'HMG-CoA reductase,' which is used to manufacture cholesterol and the drugs may also help to clear already formed cholesterol from the bloodstream. High cholesterol is a known cause of cardiovascular disease and it is well-established that statins reduce the rate of illness and death caused by cardiovascular disease. While statins can help to prevent the risk of a stroke or heart attack, some studie...
Source: Disabled World - June 8, 2015 Category: Disability Tags: Pharmaceutical - Drug Information Source Type: news

Fit middle-aged men have lower cancer risk
Conclusion This study shows that cardiovascular fitness is likely to reduce men's chances of developing lung and colorectal cancer, and appears to boost survival from cancer or cardiovascular disease in those diagnosed after the age of 65. This was based on comparing the top 40% of fittest men with the 20% least fit. The study focused on fitness and took account of major risk factors for cancer, such as smoking and blood pressure. However, it left out one important risk factor: diet. What people eat and drink is known to affect cancer risk. The fittest group may also have been the healthiest in terms of eating well and ...
Source: NHS News Feed - March 27, 2015 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news

Nanoparticles used to treat damaged arteries
Conclusion This exciting study in mice has shown that nanoparticles can be manufactured to target the plaques that form in atherosclerosis, and help stabilise them. It appears that the nanoparticles honed in on the plaques, rather than affecting other organs such as the spleen or liver, which gives an early indication that there may not be substantial side effects. However, it will be necessary to see if the same holds true for other organs. As with all mice studies, they give an indication of the likely biological effects of a new technique, but they do not provide the full picture of what may happen in humans, especially...
Source: NHS News Feed - February 19, 2015 Category: Consumer Health News Tags: Heart/lungs Medical practice Medication Source Type: news

What You Should Know Before You Schedule Your Next Doctor Appointment
Before we were able to Google our every itch and twinge and ache, we had very different relationships with our doctors. “In the early years of my career, information was something the doctor had and the patient didn’t,” Dr. Michael L. LeFevre, a professor and physician at the University of Missouri, tells The Huffington Post. Today, he says, patients bring their information to him for his input. “They want my opinion about how good the information is and what it means and how to interpret it for them in their lives.” Of course, the Internet is rife with misinformation, and sometimes a well-meaning patient will ...
Source: Healthy Living - The Huffington Post - February 10, 2015 Category: Consumer Health News Source Type: news

Behind the Headlines 2014 Quiz of the Year
In 2014, Behind the Headlines covered more than 500 health stories that made it into the mainstream media. Test your knowledge of 2014's health news with our month-by-month quiz. If you've been paying attention, you should find this quiz both easy and fun. Answers are at the foot of the page (no peeking!).   In January 2014's health news... What was said to help make bones stronger? 1) Swimming 2) Marriage 3) Listening to classical music Warnings were issued about the possible return of what? 1) Swine flu 2) The Black Death 3) Smallpox   In February 2014's health news... What activity was said to lower your ...
Source: NHS News Feed - December 29, 2014 Category: Consumer Health News Tags: Special reports Medical practice Source Type: news

Cycling linked to prostate cancer, but not infertility
Conclusion This study has looked at the associations between the number of hours spent cycling a week and erectile dysfunction, infertility and prostate cancer in men over the age of 50 who cycle regularly. It found no association between the time spent cycling and erectile dysfunction or infertility, but did find a dose-response association with prostate cancer for men over the age of 50, with risk increasing as the time a week spent cycling increased. As the researchers point out, this type of study cannot prove causality (that increased cycling time leads to prostate cancer), only an association. Different study desig...
Source: NHS News Feed - July 9, 2014 Category: Consumer Health News Tags: Cancer Lifestyle/exercise Source Type: news