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Infectious Disease: Cytomegalovirus

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Infectious Diseases: Images in Clinical Medicine
Editor: V. Dimov, M.D., Cleveland ClinicHypoglossal Nerve Palsy during Meningococcal Meningitis. NEJM, 10/2014.Herpes Zoster Involving the S1 Dermatome. NEJM, 05/2014.Tinea Faciei. NEJM, 05/2014.Disseminated Cryptococcosis in a CLL patient. 05/2014.Scrofuloderma due to Mycobacterium tuberculosis. NEJM, 06/2012.Leonine Facies in Lepromatous Leprosy. NEJM, 04/2012.Intestinal Infestation with Ancylostoma ceylanicum. NEJM, 03/2012.Kerion celsi form of tinea capitis caused by a T-cell hypersensitivity reaction. NEJM, 03/2012.Eye can see a nest of worms! Thelazia callipaeda. Lancet, 03/2012.Madura Foot. NEJM, 01/2012.Paragonimia...
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Images Infectious Diseases Source Type: news

An update on clinical, pathological, diagnostic, and therapeutic perspectives of childhood leukodystrophies.
Authors: Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR Abstract Introduction: Leukodystrophies constitute heterogenous group of rare heritable disorders primarily affecting the white matter of central nervous system. These conditions are often under-appreciated among physicians. The first clinical manifestations of leukodystrophies are often nonspecific and can occur in different ages from neonatal to late adulthood periods. The diagnosis is, therefore, challenging in most cases.Area covered: Herein, the authors discuss different aspects of leukodystrophies. The authors used...
Source: Expert Review of Neurotherapeutics - December 13, 2019 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Prevalence of herpesviruses in periodontal disease of the North Indian population: A pilot study
Conclusions: Within the limitation of this study, EBV was found in cases of periodontitis patients. Its role in disease initiation and progression is not clear. Further studies are required to ascertain EBV as risk factor in periodontal disease.
Source: Journal of Indian Society of Periodontology - March 1, 2020 Category: Dentistry Authors: Rameshwari Singhal Amita Jain Pavitra Rastogi Source Type: research

Presence of asymptomatic cytomegalovirus and Epstein--Barr virus DNA in blood of persons with HIV starting antiretroviral therapy is associated with non-AIDS clinical events
Background: Even with antiretroviral therapy (ART), persons with HIV (PWH) experience increased morbidity and mortality. Cytomegalovirus (CMV) and Epstein--Barr virus (EBV) co-infections likely exacerbate inflammatory-related diseases. Objective: To determine if presence of detectable CMV or EBV DNA in peripheral blood mononuclear cells (PBMC) is associated with non-AIDS events among PWH receiving modern ART. Design: We performed a case--control study of PWH starting ART and HIV-suppressed at year 1 and thereafter, 140 cases who experienced non-AIDS events and 305 matched controls. Events included myocardial infarc...
Source: AIDS - April 9, 2020 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Intracranial calcifications in childhood: Part 2
This article is the second of a two-part series on intracranial calcification in childhood. In Part 1, the authors discussed the main differences between physiological and pathological intracranial calcification. They also outlined histological intracranial calcification characteristics and how these can be detected across different neuroimaging modalities. Part 1 emphasized the importance of age at presentation and intracranial calcification location and proposed a comprehensive neuroimaging approach toward the differential diagnosis of the causes of intracranial calcification. Pathological intracranial calcification can ...
Source: Pediatric Radiology - July 7, 2020 Category: Radiology Source Type: research

Title: Cytomegalovirus antibody levels and mortality among hospitalized elderly patients.
Conclusions: Increased IgG antibody levels against CMV are associated with increased short and long-term mortality in elderly hospitalized patients, especially in the patients without cardiovascular disease. PMID: 32803995 [PubMed - as supplied by publisher]
Source: Annals of Medicine - August 19, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

TAT-RHIM: a more complex issue than expected
Biochem J. 2022 Jan 11:BCJ20210677. doi: 10.1042/BCJ20210677. Online ahead of print.ABSTRACTMurine cytomegalovirus protein M45 contains a RIP homotypic interaction motif (RHIM) that is sufficient to confer protection of infected cells against necroptotic cell death. Mechanistically, the N-terminal region of M45 drives rapid self-assembly into homo-oligomeric amyloid fibrils, and interacts with the endogenous RHIM domains of receptor-interacting protein kinases (RIPK) 1, RIPK3, Z-DNA binding protein 1, and TIR domain-containing adaptor-inducing interferon-β. Remarkably, all four mammalian proteins harbouring such a RHIM do...
Source: The Biochemical Journal - January 11, 2022 Category: Biochemistry Authors: Benedikt Kolbrink Theresa Riebeling Nikolas K Teiwes Claudia Steinem Hubert Kalbacher Ulrich Kunzendorf Stefan Krautwald Source Type: research

Lack of Association between Seropositivity of Vasculopathy-Related Viruses and Moyamoya Disease
CONCLUSIONS: Our cross-sectional study suggest that the investigated 11 viruses including HHV6 are unlikely to have an impact on MMD development.PMID:35500358 | DOI:10.1016/j.jstrokecerebrovasdis.2022.106509
Source: Herpes - May 2, 2022 Category: Infectious Diseases Authors: Yasuhisa Nakamura Yohei Mineharu Takahiko Kamata Takeshi Funaki Susumu Miyamoto Akio Koizumi Kouji H Harada Source Type: research

The Role of CMV Infection in Primary Lesions, Development and Clinical Expression of Atherosclerosis
J Clin Med. 2022 Jul 1;11(13):3832. doi: 10.3390/jcm11133832.ABSTRACTThe number of deaths related to cardiovascular disease is increasing every year, despite all available therapies and the aggressive campaigns for lifestyle modification and prevention of risk factors. Atherosclerosis is a complex process underlying cardiovascular disease. Cytomegalovirus (CMV) is often associated to atherosclerosis and its clinical expression such as coronary heart disease, stroke, or peripheral artery disease. CMV infection may promote acute atherosis within placentas from women with preeclampsia and it may also accelerate atherosclerosi...
Source: Atherosclerosis - July 9, 2022 Category: Cardiology Authors: Carmen Valentina Cristescu Sophie Alain Simona Maria Ru ță Source Type: research

Viruses, Vol. 14, Pages 2676: Long-Term Associations between Human Cytomegalovirus Antibody Levels with All-Cause Mortality and Cardiovascular Outcomes in an Australian Community-Based Cohort
Girish Dwivedi Human cytomegalovirus (HCMV) infection has been shown to increase the risk of cardiovascular events and all-cause death among individuals with clinically apparent cardiovascular disease (CVD). Whether this association exists in individuals with no history of CVD remains unclear. Serum levels of HCMV IgG antibody were measured using an ELISA in 2050 participants aged 40&ndash;80 years from the 1994/1995 Busselton Health Survey who did not have CVD at baseline. Outcomes were all-cause death, cardiovascular death, acute coronary syndrome (ACS) and major adverse coronary and cerebrovascular events...
Source: Viruses - November 29, 2022 Category: Virology Authors: Silvia Lee Nikki van den Berg Alison Castley Mark Divitini Matthew Knuiman Patricia Price David Nolan Frank Sanfilippo Girish Dwivedi Tags: Article Source Type: research

Cytomegalovirus and cardiovascular disease: a hypothetical role for viral G protein-coupled receptors in hypertension
Am J Hypertens. 2023 May 6:hpad045. doi: 10.1093/ajh/hpad045. Online ahead of print.ABSTRACTCytomegalovirus (CMV) is a member of the β- herpesviruses and is ubiquitous, infecting 50-99% of the human population depending on ethnic and socioeconomic conditions. CMV establishes lifelong, latent infections in their host. Spontaneous reactivation of CMV is usually asymptomatic, but reactivation events in immunocompromised or immunosuppressed individuals can lead to severe morbidity and mortality. Moreover, herpesvirus infections have been associated with several cardiovascular and post-transplant diseases (stroke, atherosclero...
Source: Atherosclerosis - May 6, 2023 Category: Cardiology Authors: Gisele F Bomfim Fernanda Priviero Emma Poole Rita C Tostes John H Sinclair Dimitrios Stamou Mark J Uline Mark R Wills R Clinton Webb Source Type: research

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