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Effects of IL-1 β on hippocampus cell apoptosis and learning ability of vascular dementia rats.
CONCLUSIONS: IL-1β can delay VD occurrence and development through the P38-MAPK signaling pathway to regulate cell apoptosis and improve learning ability. PMID: 30280789 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice.
Conclusion:Chronic administration of dl-PHPB improves learning and memory and promotes LTP in the animal models of Alzheimer's disease, possibly via increasing p-GluN2B expression in the hippocampus. PMID: 24858312 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 26, 2014 Category: Drugs & Pharmacology Authors: Li PP, Wang WP, Liu ZH, Xu SF, Lu WW, Wang L, Wang XL Tags: Acta Pharmacol Sin Source Type: research

The Effects of Sigma‐1 Receptor Selective Ligands on Muscarinic Receptor Antagonist Induced Cognitive Deficits in Mice
Conclusions and ImplicationsThe sigma‐1 receptor selective compound such as LS‐1‐137 may represent a novel candidate cognitive enhancer for the treatment of cholinergic muscarinic‐dependent cognitive deficits.
Source: British Journal of Pharmacology - January 9, 2015 Category: Drugs & Pharmacology Authors: Maninder Malik, Claudia Rangel‐Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren‐Qi Huang, Johann Meunier, Tangui Maurice, Robert H. Mach, Robert R. Luedtke Tags: Research Paper Source Type: research

The Effect of Acori graminei Rhizoma and Extract Fractions on Spatial Memory and Hippocampal Neurogenesis in Amyloid Beta 1-42 Injected Mice.
This study aimed to investigate the neuroprotective effects of different extract fractions from AGR against Alzheimer disease-like symptoms induced by Amyloid Beta (Aß) 1-42 intra-hippocampal injection. On day 7 after intra-hippocampal injection of saline or Aβ1-42, spatial memory was assessed by the first Morris water maze, followed by 3-week intra-gastric administration of saline or water extract, volatile oil fraction, or defatted decoction fraction of AGR respectively. Mice were subsequently subjected to the second Morris water maze task. Levels of Aβ1-42 and expressions of doublecortin and nestin in the hippocampus...
Source: CNS and Neurological Disorders Drug Targets - February 25, 2015 Category: Drugs & Pharmacology Authors: Ma Y, Tian S, Sun L, Yao S, Liang Z, Li S, Liu J, Zang L, Li G Tags: CNS Neurol Disord Drug Targets Source Type: research

The effects of sigma (σ1) receptor‐selective ligands on muscarinic receptor antagonist‐induced cognitive deficits in mice
Conclusions and ImplicationsThe σ1 receptor‐selective compound LS‐1–137 may represent a novel candidate cognitive enhancer for the treatment of muscarinic receptor‐dependent cognitive deficits.
Source: British Journal of Pharmacology - April 10, 2015 Category: Drugs & Pharmacology Authors: Maninder Malik, Claudia Rangel‐Barajas, Nathalie Sumien, Chang Su, Meharvan Singh, Zhenglan Chen, Ren‐Qi Huang, Johann Meunier, Tangui Maurice, Robert H Mach, Robert R Luedtke Tags: RESEARCH PAPER Source Type: research

Glycyrrhizic acid ameliorates cognitive impairment on vascular dementia model rats associated with oxidative damage and inhibition of voltage-gated sodium channels.
Abstract Vascular dementia (VD) is known to be the second most common causes of cognitive impairment in the elderly population. Our study aimed to investigate the neuroprotective of glycyrrhizic acid (GA), a major active constituent of Glycyrrhiza glabra root, on VD rats model induced by permanent occlusion of bilateral common carotid arteries. Spatial cognitive function was examined by performing Morris water maze (MWM) and synaptic plasticity was explored by long-term potential (LTP) test. The results showed that GA (20 mg/kg for 5d) significtantly improved the performance of learning and memory of VD rats in MW...
Source: CNS and Neurological Disorders Drug Targets - May 26, 2016 Category: Drugs & Pharmacology Authors: Yang J, Yao Y, Guo J, Yang CX Tags: CNS Neurol Disord Drug Targets Source Type: research

Effects of Naodesheng tablets on amyloid beta-induced dysfunction: A traditional Chinese herbal formula with novel therapeutic potential in Alzheimer's disease revealed by systems pharmacology
In conclusion, this is the first study to provide a comprehensive systems pharmacology approach to elucidate the potential therapeutic mechanism of NDS tablets for AD treatment. We suggest that the protective effects of NDS in neurodegenerative conditions could be partly attributed to its role in improving synaptic plasticity and inhibiting neuroinflammation via NF-κB signaling pathway inhibition and cAMP/PKA/CREB signaling pathway activation.PMID:34328103 | DOI:10.1016/j.biopha.2021.111916
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 30, 2021 Category: Drugs & Pharmacology Authors: Baoyue Zhang Jun Zhao Pengfei Guo Zhe Wang Lvjie Xu Ailin Liu Guanhua Du Source Type: research

A review on the neuroprotective effect of berberine against chemotherapy-induced cognitive impairment
Curr Drug Targets. 2022 Mar 3. doi: 10.2174/1389450123666220303094752. Online ahead of print.ABSTRACTChemobrain is one of the major side effects of chemotherapy, despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Though, several possibly important candidate mechanisms have been identified and will be studied further in the future. Chemobrain is characterized by memory loss, cognitive impairment, difficulty in language, concentration, acceleration, and learning. The major characteristic of chemobrain is oxidative stress, mitochondrial dysfunction, immune dysregulatio...
Source: Current Drug Targets - March 4, 2022 Category: Drugs & Pharmacology Authors: Kuleshwar Sahu Sukhdev Singh Bhawna Devi Charan Singh Arti Singh Source Type: research