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Total 3586 results found since Jan 2013.

Measuring the Effectiveness of Safety Warnings on the Risk of Stroke in Older Antipsychotic Users: A Nationwide Cohort Study in Two Large Electronic Medical Records Databases in the United Kingdom and Italy
ConclusionAntipsychotic safety warnings were followed by a reduction in stroke incidence among older antipsychotic users in the UK, but not Italy.
Source: Drug Safety - September 24, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Ginkgo Leaf Extract and Dipyridamole Injection for Ischemic Stroke: A Systematic Review and Meta Analysis
Conclusion: Evidence from the meta-analysis suggested that the combination of conventional treatments and GDI is safe and more effective in treating ischemic stroke than conventional treatments alone. Therefore, GDI mediated therapy could be recommended as an adjuvant treatment for ischemic stroke.
Source: Frontiers in Pharmacology - December 3, 2019 Category: Drugs & Pharmacology Source Type: research

Medication adherence in stroke patients in Brunei Darussalam Public Hospital: the cross ‐sectional study associated with chronic diseases, life style and potential barriers
ConclusionsThe high adherence rates in this study may be due to the good facilities of Brunei healthcare system, patients ’ increased concerns about their health, good education provided regarding their medications and family members in reminding them to take their medications.
Source: Journal of Pharmaceutical Health Services Research - January 10, 2020 Category: Drugs & Pharmacology Authors: Yeng Kwong Han, Rajan Rajabalaya, Dk Hajah Norazieda Binti Pg Hj Mohammad Yassin, Sheba R. David Tags: Research Paper Source Type: research

The Effects and Underlying Mechanisms of Cell Therapy on Blood-Brain Barrier Integrity After Ischemic Stroke.
Abstract Ischemic stroke is one of the main causes of mortality and disability worldwide. However, the efficient therapeutic strategies are still lacking. Stem/progenitor cell-based therapy, with its vigorous advantages, has emerged as a promising tool for the treatments of ischemic stroke. The mechanisms involve new neural cells and neuronal circuitry formation, antioxidation, inflammation alleviation, angiogenesis and neurogenesis promotion. In the past decades, in-depth studies have suggested that cell therapy could promote vascular stabilization and decrease blood-brain barrier (BBB) leakage after ischemic str...
Source: Current Neuropharmacology - September 13, 2020 Category: Drugs & Pharmacology Authors: Gao L, Song Z, Mi J, Hou P, Xie C, Shi J, Li Y, Manaenko A Tags: Curr Neuropharmacol Source Type: research

Potential Therapeutic Effects of Sodium Glucose-linked Cotransporter 2 Inhibitors in Stroke.
CONCLUSIONS: It is unlikely that SGLT inhibitors have a positive or negative effect on stroke risk, but the question that remains unanswered is whether SGLT inhibitors can yield a protective effect after acute ischemic stroke. Future observational studies and registries may be the first step to help answer this question. (Clin Ther. 2020; XX:XXX-XXX) © 2020 Elsevier HS Journals, Inc. PMID: 33008610 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - September 28, 2020 Category: Drugs & Pharmacology Authors: Al Hamed FA, Elewa H Tags: Clin Ther Source Type: research

Stroke patients ’ support: evaluation of knowledge, practices and training needs of French community pharmacists
Conclusion Based on this small study, the fragmented knowledge and varied practices promote the need for further training for pharmacists to optimize support of stroke patients. This study promotes the elaboration of training systems adapted to pharmacists ’ needs. This will help support the development of a targeted pharmaceutical care approach for stroke patients.
Source: International Journal of Clinical Pharmacy - January 2, 2021 Category: Drugs & Pharmacology Source Type: research

Hospitalization Expenditures and Out-Of-Pocket Expenses in Patients With Stroke in Northeast China, 2015 –2017: A Pooled Cross-Sectional Study
Conclusion: Stroke imposes a heavy financial burden on both patients and society in Liaoning Province, Northeast China. Results showed that there are some differences in the individual and social economic burden among different types of stroke. In addition, stroke patients share a high proportion of costs through OOP expenses, especially for poor social-economic status patients. Targeted intervention measures and specific policies are needed to reduce the individual and social economic burden of stroke as well as improve equity in health care among different social groups.
Source: Frontiers in Pharmacology - February 5, 2021 Category: Drugs & Pharmacology Source Type: research

Targeting brain-spleen crosstalk after stroke: new insights into stroke pathology and treatment
Curr Neuropharmacol. 2021 Mar 15. doi: 10.2174/1570159X19666210316092225. Online ahead of print.ABSTRACTThe immune response following acute stroke has received great attention. The spleen is an important immune organ, and more and more studies have shown that brain-spleen crosstalk after stroke plays an important role in its development and prognosis. There are many mechanisms of spleen activation after stroke, including activation of the sympathetic nervous system, the production of chemokines, and antigen presentation in the damaged brain. The changes in the spleen after stroke are mainly reflected in morphology, changes...
Source: Current Neuropharmacology - March 17, 2021 Category: Drugs & Pharmacology Authors: Dong Han Hang Liu Yan Gao Juan Feng Source Type: research

The Mitochondrial mitoNEET Ligand NL-1 Is Protective in a Murine Model of Transient Cerebral Ischemic Stroke
ConclusionAs support of our hypothesis, as expected, NL-1 failed to reduce stroke infarct in a permanent photothrombotic occlusion model of stroke. This report demonstrates the potential therapeutic benefits of using mitoNEET ligands like NL-1 as novel mitoceuticals for treating reperfusion-injury with cerebral stroke.
Source: Pharmaceutical Research - May 12, 2021 Category: Drugs & Pharmacology Source Type: research

Traditional Chinese Medicine Reduces the Incidence of Chemotherapy-Induced Stroke: A Five-Year Nationwide Population-Based Cohort Study From Taiwan
Conclusion: These Taiwanese data suggest that chemotherapy is a risk factor for stroke and that the use of TCM can significantly mitigate this risk. TCM also appears to reduce the mortality risk associated with chemotherapy.
Source: Frontiers in Pharmacology - May 26, 2021 Category: Drugs & Pharmacology Source Type: research