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Total 3586 results found since Jan 2013.

An audit of the pharmacological management of ischaemic stroke patients in a metropolitan Australian hospital
Conclusion The majority of the cohort was discharged on the appropriate evidence based medications for the management of secondary stroke. Further improvement may be achieved by pharmacist intervening as part of a multidisciplinary team.
Source: International Journal of Clinical Pharmacy - January 31, 2015 Category: Drugs & Pharmacology Source Type: research

Angiogenesis-regulating microRNAs and Ischemic Stroke.
Abstract Stroke is a leading cause of death and disability worldwide. Ischemic stroke is the dominant subtype of stroke and results from focal cerebral ischemia due to occlusion of major cerebral arteries. Thus, the restoration or improvement of reduced regional cerebral blood supply in a timely manner is very critical for improving stroke outcomes and poststroke functional recovery. The recovery from ischemic stroke largely relies on appropriate restoration of blood flow via angiogenesis. Newly formed vessels would allow increased cerebral blood flow, thus increasing the amount of oxygen and nutrients delivered t...
Source: Current Vascular Pharmacology - July 11, 2015 Category: Drugs & Pharmacology Authors: Yin KJ, Hamblin M, Chen YE Tags: Curr Vasc Pharmacol Source Type: research

Glucagon-like receptor 1 agonists and DPP-4 inhibitors: Anti-diabetic drugs with anti-stroke potential.
Abstract Stroke is one of the leading causes of death and serious disability in Westernized societies. The risk of stroke approximately doubles with each decade after the age of 55. Therefore, even though the incidence of stroke is declining, mostly because of the efforts to lower blood pressure and reduce smoking, the overall number of strokes is increasing due to the aging of the population. While stroke prevention by healthy lifestyle is effective in decreasing the risk of stroke, post stroke pharmacological strategies aimed at minimizing stroke-induced brain damage and promoting recovery are highly needed. Unf...
Source: Neuropharmacology - August 17, 2017 Category: Drugs & Pharmacology Authors: Darsalia V, Klein T, Nyström T, Patrone C Tags: Neuropharmacology Source Type: research

Association between caveolin-1 and stroke: a systematic review and meta-analysis.
CONCLUSIONS: Although the differences are not statistically significant between the two groups, the high level of caveolin-1 are associated with the stroke, which may remedy the stroke. Besides, an opposite result was observed for the association of the caveolin-1 on the ischemic stroke and hemorrhagic stroke. To confirm this association, further studies are necessary. PMID: 33090411 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - October 23, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The Role of Stem Cells in the Therapy of Stroke
CONCLUSION: Although further research in this field is required, post stroke brain recovery supported by exogenous stem cells seems to be promising future therapy revolutionizing modern neurology.PMID:34365923 | DOI:10.2174/1570159X19666210806163352
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Maria Ejma Natalia Madetko Anna Brzecka Piotr Alster S ławomir Budrewicz Magdalena Koszewicz Marta Misiuk-Hoj ło Irina K Tomilova Siva G Somasundaram Cecil E Kirkland Gjumrakch Aliev Source Type: research

Trial of a prehospital intervention with traditional Chinese medicine for acute stroke (TRACE): Protocol for a mixed-methods research study
Discussion: The results of the TRACE study will provide preliminary evidence for the relationship between XNJI used within 24 h of onset and the presence of END on the third day after stroke onset; it will aid in improving the current knowledge regarding the early use of XNJI for stroke first aid.Clinical Trial Registration:clinicaltrials.gov, identifier NCT04275349
Source: Frontiers in Pharmacology - August 29, 2022 Category: Drugs & Pharmacology Source Type: research

Network pharmacology and experimental study of phenolic acids in salvia miltiorrhiza bung in preventing ischemic stroke
At present, the preventive effect of ischemic stroke is not ideal, and the preventive drugs are limited. Danshen, the dried root of Salvia miltiorrhiza Bge, is a common medicinal herb in Traditional Chinese Medicine, which has been used for the treatment of cardiovascular diseases for many years. Phenolic Acids extracted from danshen, which showed multiple biological activities, have been developed as an injection for the treatment of ischemic stroke. However, its preventive effect on ischemic stroke has not been fully reported. The current study aimed to identify the potential active phenolic acids for the prevention of i...
Source: Frontiers in Pharmacology - January 27, 2023 Category: Drugs & Pharmacology Source Type: research

Is Sodium Valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case–control study
ConclusionSodium valproate exposure was associated with the risk of MI, but not ischemic stroke. However, longer exposure to SV was associated with lower odds of stroke, but this might be explained by survivor bias. © 2014 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - May 1, 2014 Category: Drugs & Pharmacology Authors: Alex Dregan, Judith Charlton, Charles D. A. Wolfe, Martin C. Gulliford, Hugh S. Markus Tags: Original Report Source Type: research

Genetic Signatures in the Treatment of Stroke.
Abstract Stroke is the fourth leading cause of mortality and neurological disability. It is caused by an intricate interplay of environmental and genetic factors. Genes not only influence susceptibility to stroke but have also been found to alter the response to pharmacological agents and may also influence the clinical outcome of the disease. Current treatment strategies for stroke include tissue plasminogen activator, antiplatelet agents and lipid lowering drugs. These act via diverse mechanisms of actions and are centered around the management of modifiable risk factors to prevent the recurrent stroke events. H...
Source: Current Pharmaceutical Design - August 26, 2014 Category: Drugs & Pharmacology Authors: Munshia A, Sharma V Tags: Curr Pharm Des Source Type: research