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Total 2334 results found since Jan 2013.

Update on Intensive Care Unit Management of Stroke
Anasthesiol Intensivmed Notfallmed Schmerzther. 2022 Mar;57(3):222-229. doi: 10.1055/a-1374-1932. Epub 2022 Mar 23.ABSTRACTIn this review, we provide an update on the intensive care unit (ICU) management of ischemic stroke. Over the last decade, new evidence has led to rapid changes in the early management of patients admitted with acute ischemic stroke. Nevertheless, stroke remains a leading cause of disability. Consequently, a significant number of patients with acute ischemic stroke require ICU level care. The most frequent reasons for ICU admissions are large infarction with potential swelling, reduced level of conscio...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - March 23, 2022 Category: Intensive Care Authors: Farid Salih Alexandra Becker Nicolai Andrees Hannah Tempel Source Type: research

Chronic high-altitude exposure and the epidemiology of ischaemic stroke: a systematic review
Conclusions This review suggests that the most robust studies are more likely to find that prolonged living at higher altitudes reduces the risk of developing stroke or dying from it. Increased irrigation due to angiogenesis and increased vascular perfusion might be the reason behind improved survival profiles among those living within this altitude range. In contrast, residing above 3500 m seems to be associated with an apparent increased risk of developing stroke, probably linked to the presence of polycythaemia and other associated factors such as increased blood viscosity.
Source: BMJ Open - April 29, 2022 Category: General Medicine Authors: Ortiz-Prado, E., Cordovez, S. P., Vasconez, E., Viscor, G., Roderick, P. Tags: Open access, Neurology Source Type: research

Perfusion of Ischemic Brain in Young and Aged Animals: A Laser Speckle Flowmetry Study Basic Sciences
Conclusions— Cerebrovascular dynamics and perfusion are not responsible for the different stroke phenotypes seen in the young versus aged animals, which may be more related to different levels of blood–brain barrier breakdown.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Manwani, B., Friedler, B., Verma, R., Venna, V. R., McCullough, L. D., Liu, F. Tags: Animal models of human disease, Acute Cerebral Infarction, Brain Circulation and Metabolism Basic Sciences Source Type: research

Pretreatment Blood-Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator Clinical Sciences
Conclusions— A perfusion-weighted imaging–derived index of blood–brain barrier damage measured before intravenous tissue-type plasminogen activator is given is associated with the severity of ICH after treatment in patients with acute ischemic stroke.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Leigh, R., Jen, S. S., Hillis, A. E., Krakauer, J. W., Barker, P. B., on behalf of the STIR and VISTA Imaging Investigators, Albers, Davis, Donnan, Fisher, Furlan, Grotta, Hacke, Kang, Kidwell, Koroshetz, Lees, Lev, Liebeskind, Sorensen, Thijs, Thomalla, Tags: CT and MRI, Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis, Other Vascular biology Clinical Sciences Source Type: research

Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI: A New Target for Fibrinolysis? Brief Reports
Conclusions— SAH and acute ischemic stroke significantly impair the glymphatic system perfusion. In these contexts, injection of tissue-type plasminogen activator either intracerebroventricularly to clear perivascular spaces (for SAH) or intravenously to restore arterial patency (for ischemic stroke) may improve glymphatic function.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Gaberel, T., Gakuba, C., Goulay, R., De Lizarrondo, S. M., Hanouz, J.-L., Emery, E., Touze, E., Vivien, D., Gauberti, M. Tags: Animal models of human disease, Fibrinolysis, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Relation between stroke severity, patient characteristics and CT-perfusion derived blood-brain barrier permeability measurements in acute ischemic stroke
Conclusion Early CT signs are related to higher BBBP values in the infarct core, suggesting that only severe ischemic damage alters BBBP within the first hours after symptom onset.
Source: Clinical Neuroradiology - February 27, 2015 Category: Neurology Source Type: research

Effects of stroke severity and treatment duration in normobaric hyperoxia treatment of ischemic stroke.
This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cerebral artery occlusion (MCAO), NBO treatment for 25min and 150min were studied. For the 90-min MCAO, NBO treatment for 55min and 150min were studied. Cerebral blood flow (CBF), apparent diffusion coefficients (ADC) and T2 MRI were acquired during occlusion prior to treatment, after reperfusion, and 48h after MCAO. The effects of NBO treatment on lesion volumes, and CBF, ADC and T2 of ischemic core, perfusion-diffusion mismatch and normal tissue were analyzed longitudinally. The...
Source: Brain Research - January 26, 2016 Category: Neurology Authors: Tiwari YV, Jiang Z, Sun Y, Du F, Rodriguez P, Shen Q, Duong TQ Tags: Brain Res Source Type: research

Computed tomography based quantification of lesion water uptake identifies patients within 4.5 hours of stroke onset: A multicenter observational study
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 6, 2016 Category: Neurology Authors: Jens Minnerup, Gabriel Broocks, Judith Kalkoffen, Soenke Langner, Michael Knauth, Marios Nikos Psychogios, Heike Wersching, Anja Teuber, Walter Heindel, Bernd Eckert, Heinz Wiendl, Peter Schramm, Jens Fiehler, Andr é Kemmling Tags: Research Article Source Type: research

Thrombolytic Therapy in Wake-Up Stroke Patients
Conclusions: Available data suggest promising strategies to identify WUS patients who may benefit from thrombolysis. Once on-going trials are complete, there may be sufficient information to redefine tPA eligibility for previously excluded patients.
Source: Clinical Neuropharmacology - May 1, 2017 Category: Neurology Tags: Review Articles Source Type: research

Analyzing Circle of Willis blood flow in ischemic stroke patients through 3D Stroke Arterial Flow Estimation.
Conclusions We present SAFE analysis for collecting detailed time-resolved cerebral arterial flow data in the entire Circle of Willis for IS. Further study with more cases may be important to test the clinical utilization of SAFE and helpful to the study of the underlying hemodynamics of stroke. PMID: 28530158 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - May 24, 2017 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Hematocrit and Stroke: A Forgotten and Neglected Link?
Semin Thromb Hemost DOI: 10.1055/s-0037-1602663Stroke is considered among the most common causes of mortality and disability, leading to dramatic socioeconomic consequences. From a pathophysiologic perspective, enhanced blood viscosity due to increased hematocrit might be associated with stroke through impaired cerebral blood perfusion. This association has remained rather neglected during previous decades, but newly emerged as an epicenter of scientific interest due to the unexpected elevation of stroke rates with sodium-glucose cotransporter-2 inhibitors, a new class of hypoglycemic drugs with otherwise dramatic cardiova...
Source: Seminars in Thrombosis and Hemostasis - June 13, 2017 Category: Hematology Authors: Stavropoulos, Konstantinos Imprialos, Konstantinos P. Bouloukou, Sofia Boutari, Chrysoula Doumas, Michael Tags: Review Article Source Type: research

E-033 The smoking-thrombolysis paradox in large vessel occlusion acute ischemic stroke after endovascular therapy
Conclusion In stroke patients treated with mechanical thrombectomy, smoking does not seem to be associated with outcomes regardless of stroke subtype or location. Disclosures J. Grossberg: None. M. Bouslama: None. L. Rebello: None. D. Haussen: None. M. Frankel: None. R. Nogueira: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Grossberg, J., Bouslama, M., Rebello, L., Haussen, D., Frankel, M., Nogueira, R. Tags: Electronic Poster Abstracts Source Type: research

Cerebral venous collaterals: a new fort for fighting ischemic stroke?
Publication date: Available online 2 December 2017 Source:Progress in Neurobiology Author(s): Lu-sha Tong, Zhen-ni Guo, Yi-bo Ou, Yan-nan Yu, Xiao-cheng Zhang, Jiping Tang, John H. Zhang, Min Lou Stroke therapy has entered a new era highlighted by the use of endovascular therapy in addition to intravenous thrombolysis. However, the efficacy of current therapeutic regimens might be reduced by their associated adverse events. For example, over-reperfusion and futile recanalization may lead to large infarct, brain swelling, hemorrhagic complication and neurological deterioration. The traditional pathophysiological understand...
Source: Progress in Neurobiology - December 2, 2017 Category: Neuroscience Source Type: research