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Total 1154 results found since Jan 2013.

Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study
CONCLUSIONS: Vitamin D deficient individuals appear to have a modest reduction of memory function without structural brain atrophy. Future studies should explore if vitamin D supplementation can improve cognitive function.PMID:33825696 | DOI:10.18632/aging.202930
Source: Aging - April 7, 2021 Category: Biomedical Science Authors: Sieglinde Zelzer Edith Hofer Andreas Meinitzer Eva Fritz-Petrin Sebastian Simstich Walter Goessler Reinhold Schmidt Markus Herrmann Source Type: research

Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing INTERVENTIONAL
CONCLUSIONS: Red blood cell–rich, fibrin-rich, and platelet-rich clot analogs that mimic clots retrieved from patients with acute ischemic stroke were created in vitro. Differing retrieval outcomes were confirmed using in vitro thrombectomy testing in a subset of clots.
Source: American Journal of Neuroradiology - July 13, 2021 Category: Radiology Authors: Fitzgerald, S. T., Liu, Y., Dai, D., Mereuta, O. M., Abbasi, M., Larco, J. L. A., Douglas, A. S., Kallmes, D. F., Savastano, L., Doyle, K. M., Brinjikji, W. Tags: INTERVENTIONAL Source Type: research

Macrocalcification of intracranial vertebral artery may be related to in-stent restenosis: lessons learned from optical coherence tomography
Conclusions This study suggests a potential relationship between macrocalcifications and the risk of in-stent restenosis of the intracranial vertebral artery. These preliminary findings obtained from a limited sample should be verified by prospective large-scale studies.
Source: Journal of NeuroInterventional Surgery - April 12, 2022 Category: Neurosurgery Authors: Xu, R., Yang, B., Li, L., Wang, T., Lu, X., Luo, J., Zhang, X., Dong, J., Wang, Y., Hua, Y., Ma, Y., Jiao, L. Tags: Ischemic stroke Source Type: research

Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model
AbstractTransient ischemic attack (TIA) presents a high risk for subsequent stroke, Alzheimer ’s disease (AD), and related dementia (ADRD). However, the neuropathophysiology of TIA has been rarely studied. By evaluating recurrent TIA-induced neuropathological changes, our study aimed to explore the potential mechanisms underlying the contribution of TIA to ADRD. In the current study, we es tablished a recurrent TIA model by three times 10-min middle cerebral artery occlusion within a week in rat. Neither permanent neurological deficit nor apoptosis was observed following recurrent TIA. No increase of AD-related biomarker...
Source: Translational Stroke Research - July 22, 2022 Category: Neurology Source Type: research

Short-Term Colony-Stimulating Factor 1 Receptor Inhibition-Induced Repopulation After Stroke Assessed by Longitudinal 18F-DPA-714 PET Imaging
Conclusion: This study highlighted the potential of 18F-DPA-714 PET/CT imaging to track microglia and macrophage repopulation after short-term CSF-1R inhibition in stroke.
Source: Journal of Nuclear Medicine - September 1, 2022 Category: Nuclear Medicine Authors: Barca, C., Kiliaan, A. J., Wachsmuth, L., Foray, C., Hermann, S., Faber, C., Schafers, M., Wiesmann, M., Zinnhardt, B., Jacobs, A. H. Tags: Basic Science Investigations Source Type: research

Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
In this study, we observed that treatment with mitochondria isolated from rat primary astrocytes enhanced cell viability and ameliorated hydrogen peroxide-damaged neurons. Interestingly, isolated astrocytic mitochondria increased the number of cells under damaged neuronal conditions, but not under normal conditions, although the mitochondrial transfer efficiency did not differ between the two conditions. This effect was also observed after transplanting astrocytic mitochondria in a rat middle cerebral artery occlusion model. These findings suggest that mitochondria transfer therapy can be used to treat acute ischemic strok...
Source: BMB Reports - October 4, 2022 Category: Biochemistry Authors: Eun-Hye Lee Minkyung Kim Seung Hwan Kim Chun-Hyung Kim Minhyung Lee Chang-Hwan Park Source Type: research