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Total 611 results found since Jan 2013.

Cardiovascular and mortality risks in older Medicare patients treated with varenicline or bupropion for smoking cessation: an observational cohort study
ConclusionCardiovascular and mortality risks were not increased in older patients treated with varenicline compared with bupropion for smoking cessation. A potential increase in the risk of stroke with varenicline could not be excluded. Treatment persistence with either drug was low. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
Source: Pharmacoepidemiology and Drug Safety - July 5, 2014 Category: Drugs & Pharmacology Authors: David J. Graham, Kunthel By, Stephen McKean, Andrew Mosholder, Cynthia Kornegay, Judith A. Racoosin, Jessica Young, Mark Levenson, Thomas E. MaCurdy, Chris Worrall, Jeffrey A. Kelman Tags: Original Report Source Type: research

Outcomes After Warfarin Initiation in a Cohort of Hemodialysis Patients With Newly Diagnosed Atrial Fibrillation
Conclusions In hemodialysis patients with incident AF, warfarin use was marginally associated with reduced risk of ischemic stroke, and there was a signal toward reduced mortality in as-treated analyses. These results support clinical equipoise regarding the use of warfarin in hemodialysis patients and underscore the need for randomized trials to fill this evidence gap.
Source: American Journal of Kidney Diseases - July 9, 2015 Category: Urology & Nephrology Source Type: research

Outcomes of Basic Versus Advanced Life Support for Out-of-Hospital Medical Emergencies.
Conclusion: Advanced life support is associated with substantially higher mortality for several acute medical emergencies than BLS. Primary Funding Source: National Science Foundation, Agency for Healthcare Research and Quality, and National Institutes of Health. PMID: 26457627 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - October 13, 2015 Category: Internal Medicine Authors: Sanghavi P, Jena AB, Newhouse JP, Zaslavsky AM Tags: Ann Intern Med Source Type: research

Prominent cardiologist calls for a halt to Watchman implants
A prominent cardiologist is calling for a stop to left atrial appendage closure procedures using Boston Scientific‘s (NYSE:BSX) Watchman device, claiming the procedures, which seek to reduce stroke in patients with nonvalvular atrial fibrillation, result in the opposite. Dr. John Mandrola argues that randomized, controlled trials of the Watchman, designed for LAA closure, showed the device failed to reduce ischemic stroke, despite being designed for just that purpose. “Yet we look away; or we let advocates distract us with complicated statistics,” Dr. Mandrola wrote in an article on Medscape. “I...
Source: Mass Device - November 10, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Cardiovascular Boston Scientific Source Type: news

Continued Use of Warfarin in Veterans with Atrial Fibrillation After Dementia Diagnosis
ConclusionDiscontinuing warfarin after a diagnosis of dementia is associated with a significant increase in stroke and mortality.
Source: Journal of the American Geriatrics Society - December 29, 2016 Category: Geriatrics Authors: Ariela R. Orkaby, Al Ozonoff, Joel I. Reisman, Donald R. Miller, Shibei Zhao, Adam J. Rose Tags: Clinical Investigations Source Type: research

Evaluation of the Cost of Comprehensive Outpatient Therapies in Patients with Malignant Brain Tumors
Conclusions: The cost of comprehensive outpatient rehabilitation in patients with malignant brain tumors is less expensive than that of patients with traumatic brain injury or stroke, which are neurological diagnoses commonly seen in day rehabilitation. This study shows that cost should not be a barrier to providing outpatient therapies to this patient population.
Source: American Journal of Physical Medicine and Rehabilitation - April 19, 2017 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Evaluation of the Cost of Comprehensive Outpatient Therapies in Patients with Malignant Brain Tumors.
CONCLUSIONS: The cost of comprehensive outpatient rehabilitation in patients with malignant brain tumors is less expensive than that of patients with traumatic brain injury or stroke, which are neurological diagnoses commonly seen in day rehabilitation. This study shows that cost should not be a barrier to providing outpatient therapies to this patient population. PMID: 27661215 [PubMed - indexed for MEDLINE]
Source: Medical Physics - April 26, 2017 Category: Physics Authors: McCarty S, Keeshin S, Eickmeyer SM, Shahpar S, Semik P, Wong AWK Tags: Am J Phys Med Rehabil Source Type: research

Long-Term Exposure to Road Traffic Noise and Nitrogen Dioxide and Risk of Heart Failure: A Cohort Study
Conclusions: Long-term exposure to NO2 and road traffic noise was associated with higher risk of heart failure, mainly among men, in both single- and two-pollutant models. High exposure to both pollutants was associated with highest risk. https://doi.org/10.1289/EHP1272 Received: 25 October 2016 Revised: 09 August 2017 Accepted: 09 August 2017 Published: 26 September 2017 Address correspondence to M. Sørensen. Diet, Genes and Environment, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark. Telephone: +45 35257626. Email: mettes@cancer.dk Supplemental Material is available online (https://doi.org/1...
Source: EHP Research - September 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Trends in Carotid Revascularization Procedures
To the Editor In a study of Medicare beneficiaries during 1999-2014, 30-day ischemic stroke or death rates after carotid endarterectomy improved (from 4.4% in 1999-2000 to 3.1% in 2013-2014), as did all-cause mortality (from 1.6% to 1.1%). In contrast, 30-day ischemic stroke or death rates after carotid artery stenting did not differ between the beginning and the end of the study period (7.0% in 1999-2000 and 7.0% in 2013-2014) and neither did all-cause mortality (4.7% in 1999-2000 and 4.8% in 2013-2014). Importantly, 30-day ischemic stroke or death rates after carotid artery stenting were higher than those recommended by ...
Source: JAMA - January 16, 2018 Category: General Medicine Source Type: research

Injection Testosterone and Adverse Cardiovascular Events: A Case ‐crossover Analysis
ConclusionsTestosterone injections were uniquely associated with short‐term risk of acute cardio‐ and cerebrovascular events in older adult men following injection receipt.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - February 15, 2018 Category: Endocrinology Authors: J. Bradley Layton, Dongmei Li, Christoph R. Meier, Julie L. Sharpless, Til St ürmer, M. Alan Brookhart Tags: Original Article Source Type: research

Injection testosterone and adverse cardiovascular events: A  case‐crossover analysis
ConclusionsTestosterone injections were uniquely associated with short‐term risk of acute cardio‐ and cerebrovascular events in older adult men following injection receipt.
Source: Clinical Endocrinology - March 6, 2018 Category: Endocrinology Authors: J. Bradley Layton, Dongmei Li, Christoph R. Meier, Julie L. Sharpless, Til St ürmer, M. Alan Brookhart Tags: ORIGINAL ARTICLE Source Type: research

Use of left atrial appendage occlusion among older cardiac surgery patients with preoperative atrial fibrillation: a national cohort study
ConclusionsSubstantial variability in use of S-LAAO exists. In many instances, the procedure is being deferred in the patients that may be poised to benefit the most (i.e., those with increased CHA2DS2-VASc score-defined stroke risk).
Source: Journal of Interventional Cardiac Electrophysiology - February 2, 2019 Category: Cardiology Source Type: research

Effectiveness and Safety of Restarting Oral Anticoagulation in Patients with Atrial Fibrillation after an Intracranial Hemorrhage: Analysis of Medicare Part D Claims Data from 2010 –2016
ConclusionsIn AF patients who survived an ICH, restarting OAC was not associated with a greater risk of recurrent ICH. Evidence from randomized controlled studies is needed to further clarify the clinical benefit of restarting OAC in this high-risk population. Further evaluation of which individuals benefit from restarting OAC is also needed to provide more clinical guidance.
Source: American Journal of Cardiovascular Drugs - December 5, 2019 Category: Cardiology Source Type: research

Race/Ethnicity and Sex-Related Differences in Direct Oral Anticoagulant Initiation in Newly Diagnosed Atrial Fibrillation: A Retrospective Study of Medicare Data.
CONCLUSION: In a national cohort of Medicare beneficiaries with newly-diagnosed AF, overall oral anticoagulant initiation was lower in blacks and women, with no difference observed by Hispanic ethnicity. Among oral anticoagulant initiators, blacks were less likely to initiate novel DOACs, with no differences identified by Hispanic ethnicity or sex. Identifying modifiable causes of treatment disparities is needed to improve quality of care for all patients with AF. PMID: 32035755 [PubMed - as supplied by publisher]
Source: Journal of the National Medical Association - February 10, 2020 Category: General Medicine Tags: J Natl Med Assoc Source Type: research

Incidence of Poststroke Depression in Patients With Poststroke Dysphagia
CONCLUSIONS: Our results demonstrated that persons with poststroke dysphagia were as, or slightly more, likely to have PSD compared to the general stroke population, and to our knowledge, they establish the first reported incidence of PSD in Medicare patients with dysphagia after AIS. Future research is warranted to further explore the effects of PSD on poststroke dysphagia.PMID:35858266 | DOI:10.1044/2022_AJSLP-21-00346
Source: American Journal of Speech-Language Pathology - July 20, 2022 Category: Speech-Language Pathology Authors: Janet Horn Kit N Simpson Annie N Simpson Leonardo F Bonilha Heather S Bonilha Source Type: research