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Drug: Magnesium

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Total 248 results found since Jan 2013.

Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis Clinical Sciences
Conclusions— This meta-analysis suggests no beneficial effect of magnesium treatment on poor outcome or DCI when started early after SAH onset. Although the number of patients was small and a beneficial effect cannot be definitively excluded, we found no justification for a new trial with early magnesium treatment after SAH.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Dorhout Mees, S. M., Algra, A., Wong, G. K. C., Poon, W. S., Bradford, C. M., Saver, J. L., Starkman, S., Rinkel, G. J. E., van den Bergh, W. M., on behalf of the writing groups of MASH-I, IMASH, MASH-II, MASH and FAST-MAG, Collaborators, van Kooten, Dirv Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Neuroprotectors Clinical Sciences Source Type: research

Erratum for Adebamowo et al. Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses. Am J Clin Nutr 2015;101:1269-77.
Authors: PMID: 26429949 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - October 1, 2015 Category: Nutrition Tags: Am J Clin Nutr Source Type: research

Erratum for Adebamowo et al. Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses. Am J Clin Nutr 2015;101:1269-77. Errata
Source: American Journal of Clinical Nutrition - October 1, 2015 Category: Nutrition Tags: Errata Source Type: research

Cerebral protection during neurosurgery and stroke
This article reviews the recent evidence on perioperative neuroprotection in patients undergoing brain surgery and in patients with acute stroke. Recent findings: With varying degrees of success, numerous pharmacological and nonpharmacological therapies have been employed to provide neuroprotection for patients during the perioperative period and after acute ischemic stroke (IAS). Recent studies have failed to demonstrate neuroprotective effects of intraoperative remifentanil or propofol use, although hypertonic saline may provide better brain relaxation than mannitol during elective intracranial surgery for tumor. Magnesi...
Source: Current Opinion in Anaesthesiology - September 3, 2015 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Keith J. Ruskin Source Type: research

O31. Magnesium homeostasis and gestational hypertension
Conclusion From a public health point of view, further studies on Mg homeostasis in pregnancy and intervention in terms of supplementation have a high priority, with the ultimate aim to develop prevention programs.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood
Conclusions: Collectively, our data reveal two distinct mechanisms underlying the restoration of visual plasticity in adulthood, and the rejuvenation of adult visual cortex following magnesium treatment provides a new avenue to develop clinical therapies for adult amblyopia, as well as to explore plasticity-based treatment of other brain diseases, such as stroke and aphasia.
Source: Molecular Brain - August 19, 2015 Category: Neuroscience Authors: Hanxiao LiuYue LiYan WangXinxing WangXu AnSiying WangLin ChenGuosong LiuYupeng Yang Source Type: research

Update on anesthetic neuroprotection
Purpose of review: Perioperative cerebral injury can result in a wide range of clinical consequences from subtle cognitive changes to devastating or fatal strokes. Although the overall incidence of perioperative stroke is low, the large and growing number of aging patients undergoing surgery and anesthesia is placing an increasing number of vulnerable patients at risk. The purpose of this review is to evaluate recent evidence concerning the use of pharmacological and nonpharmacological strategies to protect against perioperative cerebral injury. Recent findings: Although a growing body of preclinical literature suggests th...
Source: Current Opinion in Anaesthesiology - July 3, 2015 Category: Anesthesiology Tags: DRUGS IN ANESTHESIA: Edited by Tong J. Gan Source Type: research

Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep.
This article is protected by copyright. All rights reserved. PMID: 26077461 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 16, 2015 Category: Physiology Authors: Galinsky R, Davidson JO, Drury PP, Wassink G, Lear CA, van den Heuij LG, Gunn AJ, Bennet L Tags: J Physiol Source Type: research

Intakes of magnesium, potassium, and calcium and the risk of stroke among men
ConclusionsA diet rich in magnesium, potassium, and calcium may contribute to reduced risk of stroke among men. Because of significant collinearity, the independent contribution of each cation is difficult to define.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Sally N. Adebamowo, Donna Spiegelman, Alan J. Flint, Walter C. Willett, Kathryn M. Rexrode Tags: Research Source Type: research

Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses Nutritional epidemiology and public health
Conclusions: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women.
Source: American Journal of Clinical Nutrition - June 1, 2015 Category: Nutrition Authors: Adebamowo, S. N., Spiegelman, D., Willett, W. C., Rexrode, K. M. Tags: Nutritional Epidemiology Research Articles Nutritional epidemiology and public health Source Type: research

The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort
This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population.
Source: International Journal of Cardiology - May 30, 2015 Category: Cardiology Authors: Lucy K.M. Bain, Phyo K. Myint, Amy Jennings, Marleen A.H. Lentjes, Robert N. Luben, Kay-Tee Khaw, Nick J. Wareham, Ailsa A. Welch Source Type: research

Neuroprotection After Major Cardiovascular Surgery
Opinion statement Neurologic injury is a common complication of major cardiovascular procedures including coronary artery bypass graft (CABG) surgery, coronary valve replacement, and aortic aneurysm surgery. However, despite ongoing research in the field of neuroprotection, there are currently few pharmacologic and interventional options to effectively protect the brain and spinal cord in the postoperative period. CSF drainage after aortic surgery currently stands as the only neuroprotective intervention that has been consistently shown to protect the spinal cord from ischemic injury, leading to significantly few...
Source: Current Treatment Options in Neurology - May 15, 2015 Category: Neurology Source Type: research

Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses.
CONCLUSIONS: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women. PMID: 25948665 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - May 6, 2015 Category: Nutrition Authors: Adebamowo SN, Spiegelman D, Willett WC, Rexrode KM Tags: Am J Clin Nutr Source Type: research

Admission Hypomagnesemia Predicts Primary Intracerebral Hemorrhage Volume (P3.093)
CONCLUSIONS: Hypomagnesemia was associated with higher admission ICH volumes in patients with lower ICH severity. While the study was limited by small numbers, a similar relationship between magnesium and ICH volume was not detected amongst patients with more severe ICH. Future studies are needed to determine if correction improves functional outcome in any targeted group of patients with ICH.Disclosure: Dr. Shiue has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. Sands has nothing to disclose. Dr. Martin-Schild has received personal compensation for activities with Genentech as a speakers bureau participant....
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shiue, H., Boehme, A., Sands, K., Martin-Schild, S., Hays Shapshak, A., Lyerly, M., Gadpaille, A., Khawaja, A., Sisson, A., Alvi, M., George, A., Harrigan, M. Tags: Cerebrovascular Disease and Interventional Neurology: Intracerebral Hemorrhage Source Type: research

Prehospital Initiation of Magnesium Sulfate in Patients with Acute Intracerebral Hemorrhage (S39.003)
Conclusions: Prehospital initiation permitted start of Mg therapy within the first 45 minutes of symptom onset in over half of patients, but did not alter rates of clinical deterioration in the first hours or disability at 3 months. Study Supported by NIH-NINDS Award U01 NS 44364Disclosure: Dr. Sanossian has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals, Inc. as a speakers bureau participant. Dr. Starkman has received research support from the National Institutes of Health, Lundbeck Research USA, Inc., Mitsubishi Tanabe Pharma, and Neurobiological Technologies, Inc. Dr. Liebeskind ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sanossian, N., Starkman, S., Liebeskind, D., Hamilton, S., Eckstein, M., Stratton, S., Pratt, F., Conwit, R., Sung, G., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: Intracerebral Hemorrhage Source Type: research