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Drug: Ambien

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Total 23 results found since Jan 2013.

Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target
Ischaemic stroke is the leading cause of severe long-term disability yet lacks drug therapies that promote the repair phase of recovery. This repair phase of stroke occurs days to months after stroke onset and involves brain remapping and plasticity within the peri-infarct zone. Elucidating mechanisms that promote this plasticity is critical for the development of new therapeutics with a broad treatment window. Inhibiting tonic (extrasynaptic) GABA signalling during the repair phase was reported to enhance functional recovery in mice suggesting that GABA plays an important function in modulating brain repair. While tonic G...
Source: Brain - January 29, 2016 Category: Neurology Authors: Hiu, T., Farzampour, Z., Paz, J. T., Wang, E. H. J., Badgely, C., Olson, A., Micheva, K. D., Wang, G., Lemmens, R., Tran, K. V., Nishiyama, Y., Liang, X., Hamilton, S. A., ORourke, N., Smith, S. J., Huguenard, J. R., Bliss, T. M., Steinberg, G. K. Tags: CNS Injury and Stroke Original Articles Source Type: research

Ischemic stroke after pellet embolization
A 9-year-old boy was shot with a pellet shotgun and developed a visual field deficit. Head CT revealed a pellet in the left ambien cistern, in the left posterior cerebral artery on catheter angiography (figure). Chest fluoroscopy revealed multiple thoracic pellets, including a mobile cardiac pellet (video on the Neurology® Web site at Neurology.org). There was no clear cardiac injury, patent foramen ovale, or skull penetration. Arterial embolization of a pellet from the chest to the intracranial vasculature likely caused a stroke.1,2 We considered arteriotomy, endovascular retrieval, and medical therapy. The establishe...
Source: Neurology - June 8, 2015 Category: Neurology Authors: Aghaebrahim, A., Giurgiutiu, D.-V., Jankowitz, B. T., Jovin, T., Jadhav, A. P. Tags: All Cerebrovascular disease/Stroke, Embolism VIDEO NEUROIMAGES Source Type: research

Cheap NHS sleeping pill could help stroke victims recover more quickly
Zolpidem could help repair the damaged connections in the brain caused by a stroke
Source: Telegraph Health - December 18, 2015 Category: Consumer Health News Tags: cure stanford treatment symptoms breakthough insomnica stroke sleeping pill Zolpidem Source Type: news

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Association of hypnotics with stroke risk: a population-based case-control study.
CONCLUSIONS: This study shows that, in a case-control study matched for age, gender, and comorbidities using multiple logistic regression and sensitivity tests, zolpidem and estazolam were slightly associated with an increased risk of stroke. Further large-scale and in-depth studies should be performed. Use of hypnotics should always be determined by specialists, and adverse effects should be continuously monitored. PMID: 25133061 [PubMed]
Source: Primary Care - August 19, 2014 Category: Primary Care Authors: Lee CC, Tsai KY, Hung YT, Chou FH, Huang YS Tags: Prim Care Companion CNS Disord Source Type: research

Update on pharmacotherapy for stroke and traumatic brain injury recovery during rehabilitation
This article evaluates whether specific drugs are able to facilitate motor recovery after stroke or improve the level of consciousness, cognitive, or behavioral symptoms after traumatic brain injury. Recent findings: After stroke, serotonin reuptake inhibitors can enhance restitution of motor functions in depressed as well as in nondepressed patients. Erythropoietin and progesterone administered within hours after moderate to severe traumatic brain injury failed to improve the outcome. A single dose of zolpidem can transiently improve the level of consciousness in patients with vegetative state or minimally conscious stat...
Source: Current Opinion in Neurology - November 8, 2016 Category: Neurology Tags: TRAUMA AND REHABILITATION: Edited by Bruce H. Dobkin Source Type: research

A review of the evidence of zolpidem efficacy in neurological disability after brain damage due to stroke, trauma and hypoxia: A justification of further clinical trials.
Authors: Sutton JA, Clauss RP Abstract During 15 years, 23 clinical reports and 6 studies have demonstrated associations between sub-sedative doses of zolpidem and recoveries from brain damage due to strokes, trauma and hypoxia. Clinical findings include unexpected awakenings from vegetative states and regressions of stroke symptoms after dosing that disappear during elimination and reappear on repeat dosing. Initially single-photon emission computed tomography scans showed improved perfusion within, around and distant from infarctions. Then positron emission tomography scans and electroencephalography detected ren...
Source: Brain Injury - May 24, 2017 Category: Neurology Tags: Brain Inj Source Type: research

Stroke recovery in mice improved by Ambien, study shows
Mice that had strokes rebounded significantly faster if they received low doses of a popular sleeping aid, according to researchers. Zolpidem, better known by the trade name Ambien, has long been approved by the U.S. Food and Drug Administration for treating insomnia. But it has never before been definitively shown to enhance recovery from stroke.
Source: ScienceDaily Headlines - December 18, 2015 Category: Science Source Type: news

Ambien shown to aid pace of stroke recovery in mice
Stephen FellerSTANFORD, Calif., Dec. 18 (UPI) -- Researchers at Stanford found Ambien helped mice recover more quickly after having a stroke, though it is unclear whether the same would be true for humans.
Source: Health News - UPI.com - December 18, 2015 Category: Consumer Health News Source Type: news

An Increased Risk of Reversible Dementia May Occur After Zolpidem Derivative Use in the Elderly Population: A Population-Based Case-Control Study
Abstract: We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD). A retrospective population-based nested case–control study. Newly diagnosed dementia patients 65 years and older and controls were sampled. A total of 8406 dementia and 16,812 control subjects were enrolled from Taiwan NHIRD during 2006 to 2010. The relationships between zolpidem use and dementia were measured using odds and adjusted odds ratios. The relationship between the average cumulative doses for zolpidem and dementia was also analyzed. Zolpidem alone or wi...
Source: Medicine - May 1, 2015 Category: Internal Medicine Tags: Article: Observational Study Source Type: research

A 69-year-old woman with a "sweet" cause of instability
A 69-year-old woman presented to the emergency department with dizziness and instability. She had a history of peripheral vertigo, tinnitus, and one episode of orthostatic syncope in recent years; her only daily medication was zolpidem. Her past medical history was unremarkable.
Source: Nature Clinical Practice - August 17, 2015 Category: Neurology Authors: Bocos-Portillo, J., Ruisanchez, A., Vazquez-Picon, R., Martinez-Arroyo, A., Pinedo-Brochado, A., Gomez-Beldarrain, M., Garcia-Monco, J. C. Tags: All Clinical Neurology, All Medical/Systemic disease, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, All Toxicology Cases Source Type: research

10 Sleep Technologies: How Much Snore for the Dollar?
Do you want better sleep? Of course you do. You know how bad it is to miss out on sleep, so it can feel like insult added to injury to read yet another newfound, devastating consequence of insufficient sleep: heart disease, heart attack, high blood pressure, stroke, diabetes, mental impairment, etc. And the list is expanding almost daily as researchers learn more. There are "easy" actions that may aid with sleep. Relaxation activities like meditation or chamomile tea are useful for some. Setting and sticking to a waking and sleeping schedule, creating a bedroom retreat, and making a list of worries before turning in can he...
Source: Healthy Living - The Huffington Post - October 27, 2015 Category: Consumer Health News Source Type: news

Controversial sleeping pill helps mice recover from strokes
Mice recovered faster after a stroke when given Ambien, the best-selling sleeping pill that has also been reported to rouse some minimally conscious people
Source: New Scientist - Health - December 18, 2015 Category: Consumer Health News Source Type: research

Will Too Much Sleep Make You Fat?
In last week's article, you learned exactly how not getting enough sleep (less than about 7 hours per night), can cause fat gain, muscle loss and an inability to control the appetite, along with increased risk for a host of chronic diseases such as diabetes and obesity. But the solution is definitely not to begin sleeping as much as you possibly can. Oversleeping may seem like a good idea to fight off the fat gain that can accompany undersleeping, but it's been shown that sleeping in excess of 9 hours per night can be just as damaging to your sleep cycles and your waistline as not getting enough sleep, and in this article...
Source: Healthy Living - The Huffington Post - August 5, 2016 Category: Consumer Health News Source Type: news

Sleep Deprivation Is Killing You And Your Career
The next time you tell yourself that you'll sleep when you're dead, realize that you're making a decision that can make that day come much sooner. Pushing late into the night is a health and productivity killer. The short-term productivity gains from skipping sleep to work are quickly washed away by the detrimental effects of sleep deprivation on your mood, ability to focus, emotional intelligence, and access to higher-level brain functions for days to come. The negative effects of sleep deprivation are so great that people who are drunk outperform those lacking sleep. Why You Need Adequate Sleep to Perform We've always...
Source: Healthy Living - The Huffington Post - September 17, 2016 Category: Consumer Health News Source Type: news