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Drug: Colchicine

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Total 88 results found since Jan 2013.

Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment
In conclusion, we have established an intravital strategy to directly investigate pathophysiology in the ischemic border zone, and found that colchicine administration in the acute phase of ischemic stroke is a potential novel therapeutic strategy.
Source: Translational Stroke Research - April 20, 2022 Category: Neurology Source Type: research

Role of Colchicine in Stroke Prevention: An Updated Meta-Analysis
Background: Colchicine is a microtubule inhibitor with anti-inflammatory properties. As the body and quality of evidence regarding the efficacy of colchicine for cardiovascular prevention is controversial, the aims of this study was to evaluate the effect of colchicine therapy on vascular events. Methods: A meta-analysis was performed of randomized controlled clinical trials of colchicine on high cardiovascular risk populations, reporting data from stroke, myocardial infarction, cardiovascular mortality and all-cause mortality, after searching the PubMed/MEDLINE, Embase and Cochrane Controlled Trials databases.
Source: Journal of Stroke and Cerebrovascular Diseases - March 8, 2020 Category: Neurology Authors: Walter Masson, Mart ín Lobo, Graciela Molinero, Gerardo Masson, Augusto Lavalle-Cobo Source Type: research

Stroke Prevention in Atrial Fibrillation: Looking Forward.
Abstract Ischemic strokes related to atrial fibrillation are highly prevalent, presenting with severe neurologic syndromes and associated with high risk of recurrence. Although advances have been made in both primary and secondary stroke prevention for patients with atrial fibrillation, the long-term risks for stroke recurrence and bleeding complications from antithrombotic treatment remain substantial. We summarize the major advances in stroke prevention for patients with atrial fibrillation during the past 30 years and focus on novel diagnostic and treatment approaches currently under investigation in ongoing cl...
Source: Circulation - December 15, 2020 Category: Cardiology Authors: Katsanos AH, Kamel H, Healey JS, Hart RG Tags: Circulation Source Type: research

Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke
Circ Res. 2022 Apr 15;130(8):1167-1186. doi: 10.1161/CIRCRESAHA.121.319994. Epub 2022 Apr 14.ABSTRACTInflammation and immune mechanisms are crucially involved in the pathophysiology of the development, acute damage cascades, and chronic course after ischemic stroke. Atherosclerosis is an inflammatory disease, and, in addition to classical risk factors, maladaptive immune mechanisms lead to an increased risk of stroke. Accordingly, individuals with signs of inflammation or corresponding biomarkers have an increased risk of stroke. Anti-inflammatory drugs, such as IL (interleukin)-1β blockers, methotrexate, or colchicine, r...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Matthias Endres Maria A Moro Christian H Nolte Claudia Dames Marion S Buckwalter Andreas Meisel Source Type: research

Colchicine for Stroke Prevention: A Systematic Review and Meta-Analysis.
Abstract PURPOSE: There has been recent interest in the role of colchicine in cardiovascular diseases, given the implication of inflammation in the pathogenesis of atherothrombosis. This systematic review assessed the role of colchicine in preventing primary or secondary stroke/transient ischemic attack (TIA) in an adult population. METHODS: Four databases were electronically searched: MEDLINE, EMBASE, CENTRAL (Cochrane Central Register of Controlled Trials), and OpenGrey. Studies were eligible if they reported stroke or TIA incidence as a primary/secondary end point, or as an adverse event. Only case-control...
Source: Clinical Therapeutics - February 27, 2019 Category: Drugs & Pharmacology Authors: Khandkar C, Vaidya K, Patel S Tags: Clin Ther Source Type: research

Pharmacotherapy for stroke prevention in nonvalvular atrial fibrillation: current strategies and future directions
This article reviews current pharmacotherapeutic options for prevention of stroke in NVAF, paying special attention to their use in particular clinical settings (e.g.: cardioversion, catheter ablation). We also aim to review new drug candidates that have entered clinical studies in this indication.EXPERT OPINION: Oral anticoagulant therapy (OAT) remains the mainstay for ischemic stroke prophylaxis in NVAF in patients at risk. Several oral (asundexian, milvexian) and parenteral (abelacimab, osocimab, xisomab, IONIS-FXIRX, fesomersen) factor XIa inhibitors are under development. These new compounds appear to be associated wi...
Source: Expert Opinion on Pharmacotherapy - November 18, 2022 Category: Drugs & Pharmacology Authors: Antonio G ómez-Outes M Luisa Su árez-Gea Alejandro-Isidoro P érez-Cabeza Jose Manuel Garc ía-Pinilla Source Type: research

Acute stroke in familial Mediterranean fever: An analysis of 23 new cases and systematic review of the literature
DiscussionThe acute stroke phenotype in FMF cases is herein described for the first time. Several clinicoradiological features such as thrombotic lacunar infarcts located in the central mesencephalon seem so typical that we recommend searching for FMF mutations in geographic regions where FMF is common.
Source: International Journal of Rheumatic Diseases - February 7, 2023 Category: Rheumatology Authors: Mehmet Akif Topcuoglu, Cansu Ayvacioglu ‐Cagan, Ethem Murat Arsava, Pınar Acar‐Ozen, Umut Kalyoncu, Rahsan Gocmen, Tayfun Hilmi Akbaba, Banu Balcı‐Peynircioğlu, Meryem Aslı Tuncer Tags: ORIGINAL ARTICLE Source Type: research

The use of colchicine as an anti-inflammatory agent for stroke prevention in patients with coronary artery disease: a systematic review and meta-analysis
ConclusionsThe use of colchicine reduces the risk of stroke in patients with a history of coronary artery disease, without a significant increase in gastrointestinal and myopathy/myalgia adverse effects.
Source: Journal of Thrombosis and Thrombolysis - May 10, 2022 Category: Hematology Source Type: research

Effect of different doses of colchicine on high sensitivity C-reactive protein in patients with acute minor stroke or transient ischemic attack: A pilot randomized controlled trial
CONCLUSION: Early treatment with low dose of colchicine reduced hsCRP levels in the patients with acute minor ischemic stroke and TIA.PMID:36041708 | DOI:10.1016/j.ejps.2022.106288
Source: European Journal of Pharmaceutical Sciences - August 30, 2022 Category: Drugs & Pharmacology Authors: Baoshi Yuan Xia Meng Anxin Wang Siying Niu Xuewei Xie Jing Jing Hao Li Liguo Chang Yongjun Wang Jiejie Li Source Type: research