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Total 133 results found since Jan 2013.

STARTING-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis for Stroke Clinical Sciences
Background and Purpose—Symptomatic intracerebral hemorrhage (sICH) is a rare but the most feared complication of intravenous thrombolysis for ischemic stroke. We aimed to develop and validate a nomogram for individualized prediction of sICH in intravenous thrombolysis–treated stroke patients included in the multicenter SITS-ISTR (Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register).Methods—All patients registered in the SITS-ISTR by 179 Italian centers between May 2001 and March 2016 were originally included. The main outcome measure was sICH per the European Cooperative Acute Str...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Manuel Cappellari, Gianni Turcato, Stefano Forlivesi, Cecilia Zivelonghi, Paolo Bovi, Bruno Bonetti, Danilo Toni Tags: Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Impact on Prehospital Delay of a Stroke Preparedness Campaign Clinical Sciences
Conclusions—Our campaign was not effective in reducing prehospital delay. Even if some limitations of the intervention, mainly in terms of duration, are taken into account, our study demonstrates that new communication strategies should be tested before large-scale implementation.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01881152.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Licia Denti, Caterina Caminiti, Umberto Scoditti, Andrea Zini, Giovanni Malferrari, Maria Luisa Zedde, Donata Guidetti, Mario Baratti, Luca Vaghi, Enrico Montanari, Barbara Marcomini, Silvia Riva, Elisa Iezzi, Paola Castellini, Silvia Olivato, Filippo Bar Tags: Treatment, Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

The outcome measures for loss of functionality in the activities of daily living of adults after stroke: a systematic review.
CONCLUSION: This review has emphasized the need for agreement among researchers as to which tool must be studied in depth or adapted to other national contexts in order to develop universal norms and standards. PMID: 30774018 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - February 18, 2019 Category: Neurology Authors: Giovanni G, Francesca I, Rita S, Valter S, Roberta M, Auxiliadora Marquez M, Sansoni J, Berardi A Tags: Top Stroke Rehabil Source Type: research

Stroke incidence and 30‐day and six‐month case fatality rates in Udine, Italy: a population‐based prospective study
ConclusionsOur study shows incidence rates higher than previously reported in our region but not supporting the view of higher incidence rates in Northern than in Southern Italy. Results contribute to time‐trends analysis on epidemiology, useful for dimensioning services in Italy and show the persistence of a gap between the outcome of stroke in Italy and that of the best performing European countries, urging to adopt better stroke management plans.
Source: International Journal of Stroke - March 21, 2013 Category: Neurology Authors: Francesco Janes, Gian Luigi Gigli, Lucio D'Anna, Iacopo Cancelli, Anna Perelli, Giessica Canal, Valentina Russo, Barbara Zanchettin, Mariarosaria Valente Tags: Research Source Type: research

Ischemic Stroke in the Very Elderly: Experience from an Italian Stroke Unit Hub Over a Period of 8 Years in the Era of Thrombectomy
Industrialized countries witnessed a staggering increase in life expectancy in the last century.1 In Italy, as in many western countries, demographic growth is stagnant and life expectancy reached an average of 84 years old.2 Since age is one of the most important non-modifiable risk factors for stroke,3 the number of patients affected by ischemic stroke will increase and elderly patients, who are particularly susceptible to vascular diseases, will eventually represent the majority of stroke victims.
Source: Journal of Stroke and Cerebrovascular Diseases - March 27, 2021 Category: Neurology Authors: Lorenzo Ricci, Marilena Mangiardi, Jacopo Lanzone, Alfredo De Liso, Adriana Fallacara, Maria Cristina Bravi, Francesca Romana Pezzella, Sabrina Anticoli Source Type: research

An update on Italian Stroke Organization guidelines on carotid endarterectomy and stenting
One hundred and fifty‐three authors, 45 Italian scientific societies, and two Italian patients’ associations participated in drafting the Italian Stroke Organization document, which has become the national guideline for the prevention and treatment of stroke in Italy. For the surgical therapy section of the Italian Stroke Organization document, the main trials on carotid endoarterectomy and stenting were critically reviewed in order to formulate recommendations for these procedures. Recommendations are presented here for the referral of patients to either carotid endarterectomy or stenting on the basis of whether carot...
Source: International Journal of Stroke - December 22, 2013 Category: Neurology Authors: Gaetano Lanza, Stefano Ricci, Carlo Setacci, Patrizio Castelli, Claudio Novalil, Carlo Pratesi, Francesco Speziale, Alberto Cremonesi, Ernesto Morlacchi, Jessica Lanza, Paola Santalucia, Augusto Zaninelli, Gian Franco Gensini Tags: Review Source Type: research

Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke
The serum level of osteoprotegerin (encoded by OPG or TNFRSF11B) was previously shown to be increased in patients with ischemic stroke. A single nucleotide polymorphism rs3134069 in the TNFRSF11B gene was previously associated with ischemic stroke in a population of diabetic patients in Italy. It remains to be determined whether rs3134069 is associated with ischemic stroke in the general population or populations without diabetes.
Source: Journal of Stroke and Cerebrovascular Diseases - February 28, 2018 Category: Neurology Authors: Xin Xiong, Duraid Hamied Naji, Binbin Wang, Yuanyuan Zhao, Junhan Wang, Dan Wang, Yuting Zhang, Sisi Li, Shanshan Chen, Yufeng Huang, Qin Yang, Xiaojing Wang, Dan Yin, Xin Tu, Qiuyun Chen, Xu Ma, Chengqi Xu, Qing K. Wang Source Type: research

The impact of Covid-19 lockdown on stroke admissions and treatments in Campania
This study analyses the impact of Covid-19 pandemic and lockdown measures on the incidence of stroke, in Campania, the most densely-populated region in Italy.Methods: we retrospectively analysed data regarding acute stroke patients presenting at 5 Campania stroke hubs, before and after the issue of lockdown in Italy on March 9th, 2020.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Candelaresi Paolo, Manzo Valentino, Giovanna Servillo, Muto Mario, Barone Paolo, Napoletano Rosa, Saponiero Renato, Andreone Vincenzo, Palma Vincenzo, Spitaleri Daniele, D'Onofrio Florindo, Maniscalco Giorgia, Salvatore Simona, Leone Giuseppe, Capone Elis Source Type: research

Predicting the Risk of Stroke in Chinese Internal Carotid Artery Stenosis Patients Underwent Carotid Artery Stenting: Validation and Improvement of Siena Carotid Artery Stenting Risk Score
Background: Siena carotid artery stenting (CAS) risk score is developed based on Chinese internal carotid artery (ICA) stenosis patients recruited in Italy, whether it is equally applicable in Chinese remains unknown. We aimed to investigate Siena CAS risk score value for predicting stroke risk in ICA stenosis patients underwent CAS and explore additional factors for improving accuracy of scoring system. Methods: Totally 401 patients with ICA stenosis who underwent CAS were enrolled. The clinical data (including patient characteristics, lesion features, and procedure-related features) were collected and the Siena CAS score was calculated.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2019 Category: Neurology Authors: Huchuan Zhou, Lin Shen, Fei Wei, Jie Shuai Source Type: research

Impact of the sars-cov-2 pandemic on the endovascular treatment of acute stroke – an italian single-center experience
: The SARS-CoV-2 pandemic greatly influenced the overall quality of healthcare. The purpose of this study was to compare the time variables for acute stroke treatment and evaluate differences in the pre-hospital and in-hospital care before and during the SARS-CoV-2 pandemic, as well as between the first and second waves.
Source: Journal of Stroke and Cerebrovascular Diseases - August 2, 2021 Category: Neurology Authors: Guglielmo Pero, Hugo Mota D ória, Matteo Giavarini, Luca Quilici, Amedeo Cervo, Antonio Macera, Mariangela Piano Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Corticospinal Tract Integrity and Long-Term Hand Function Prognosis in Patients With Stroke
Conclusions: The present study showed that CST integrity (at 6 months after onset) in patients with chronic stroke was related to functional hand status. In addition, the mid-pons FA value was more predictive of functional restoration of the hand than the FN or FA value at the pontomedullary junction. These results may be useful in predicting the functional restoration of the hand and understanding the functional prognosis of stroke. Introduction Restoration of hand function is one of the most important goals for patients with stroke (1). Thus, techniques that aid in predicting restoration of hand function are also i...
Source: Frontiers in Neurology - April 14, 2019 Category: Neurology Source Type: research