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Total 42 results found since Jan 2013.

Population-Based Study of Cerebral Microbleeds in Stroke-Free Older Adults Living in Rural Ecuador: The Atahualpa Project Brief Reports
Conclusions— Prevalence of CMB in stroke-free older adults living in Atahualpa is comparable with those reported from other ethnic groups. There is a strong relationship between CMB and increased age, high systolic blood pressure, silent markers of cerebral small vessel disease, and cortical atrophy.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Del Brutto, V. J., Zambrano, M., Mera, R. M., Del Brutto, O. H. Tags: Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke Brief Reports Source Type: research

Stroke in rural coastal Ecuador: a community‐based survey
Stroke will be South America's next epidemic. Therefore, information on stroke particularities in the region will help to overcome its impact burden. We evaluated prevalence, pattern of sub‐types, and pathogenic mechanisms underlying stroke in Atahualpa, a village representative of rural coastal Ecuador. In a three‐phase epidemiologic study, suspected cases were detected by a door‐to‐door survey (Phase I). Then, neurologists evaluated suspected cases and randomly selected negative persons (Phase II), and confirmed patients underwent complementary exams (Phase III). We found 20 stroke patients (mean age 70 years, 60...
Source: International Journal of Stroke - August 1, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Milton Santamaría, Mauricio Zambrano, Ernesto Peñaherrera, Freddy Pow‐Chon‐Long, Victor J. Del Brutto, Elio. Ochoa, Elsy Valdiviezo, Rocío Santibáñez Tags: Panorama Source Type: research

Door‐to‐door survey of cardiovascular health, stroke, and ischemic heart disease in rural coastal Ecuador – the Atahualpa Project: methodology and operational definitions
DiscussionImplementation of public health strategies directed to improve the cardiovascular health status of a given population must be based on studies evaluating specific risk factors at regional levels. Epidemiologic surveys such as the Atahualpa Project may prove cost‐effective in improving the cardiovascular health status of people living in Latin American rural villages by increasing the knowledge on the particular needs of these populations.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Ernesto Peñaherrera, Elio Ochoa, Milton Santamaría, Mauricio Zambrano, Victor J. Del Brutto, Tags: Protocols Source Type: research

Cardiovascular Health Status and Metabolic Syndrome in Ecuadorian Natives/Mestizos Aged 40 Years or More with and without Stroke and Ischemic Heart Disease—An Atahualpa Project Case–Control Nested Study
Conclusions: This case–control study suggests that none of the measured risk factors is associated with the occurrence of vascular events. It is possible that some yet unmeasured risk factors or an unknown genetic predisposition may account for a sizable proportion of stroke and ischemic heart disease occurring in the native/mestizo population of rural coastal Ecuador.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Martha Montalván, Victor J. Del Brutto, Mauricio Zambrano, Milton Santamaría, Daniel Tettamanti Tags: Original Articles Source Type: research

Cognitive performance in community-dwelling older adults with stroke and the contribution of age and diffuse subcortical damage: a population-based study in rural Ecuador (The Atahualpa Project).
CONCLUSIONS: Interaction of age and diffuse subcortical damage are major determinants for poor cognitive performance among stroke patients. PMID: 25724660 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - February 28, 2015 Category: Geriatrics Authors: Del Brutto OH, Mera RM, Zambrano M, Lama J Tags: Aging Clin Exp Res Source Type: research

Stroke-Related Mortality at Different Altitudes: A 17-Year Nationwide Population-Based Analysis From Ecuador
Conclusion: This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has a stronger effect between 2,000 and 3,500 m.
Source: Frontiers in Physiology - September 30, 2021 Category: Physiology Source Type: research

Ethnodemographic characterization of stroke incidence and burden of disease in hospital discharge records in Ecuador
DiscussionDifferences in the burden of disease by ethnic group are likely to reflect differential access to care by region and socio-economic group, both of which are frequently correlated with ethnic composition in Ecuador. Equitable access to health services remains an important challenge in the country. The gender discrepancy in fatality rates suggests that there is a need for targeted educational campaigns to identify stroke signs early, especially in the female population.
Source: Frontiers in Neurology - February 8, 2023 Category: Neurology Source Type: research

Management of Stroke with Pharmacological Fibrinolysis in an Emergency Department at a Level 2 Hospital in Central Ecuador
In this study we report the initial results of the first code stroke and fibrinolysis pathway established in a level 2 public hospital in a small city (pop 300,000) in Ecuador.Objective: To develop an organized and coordinated pathway within the hospital for the correct diagnosis and treatment of patients with clinical presentation of stroke, starting with early identification of signs/symptoms and the activation of a specific pathway, which in turn improves the prognosis and the quality of life of acute ischemic stroke patients.Methods: This was a prospective, longitudinal,...
Source: Western Journal of Emergency Medicine - February 24, 2020 Category: Emergency Medicine Source Type: research

The Importance of Neurocysticercosis in Stroke in Rural Areas of a Developing Latin American Country.
This study suggests that NCC is not responsible for the increasing burden of stroke in rural areas of developing countries. PMID: 23836572 [PubMed - as supplied by publisher]
Source: The American Journal of Tropical Medicine and Hygiene - July 8, 2013 Category: Tropical Medicine Authors: Del Brutto OH, Lama J, for the Atahualpa Project Investigators Tags: Am J Trop Med Hyg Source Type: research

Cerebrovascular Correlates of Sleep Disorders—Rational and Protocol of a Door-to-Door Survey in Rural Coastal Ecuador
Discussion: This epidemiologic study may prove cost-effective in improving sleep conditions of people living in rural areas of developing countries and may be used as a model for the evaluation of sleep disorders and their cerebrovascular correlates in these populations.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Rodolfo Farfán, Pablo R. Castillo, Atahualpa Project Investigators Tags: Original Articles Source Type: research

White matter hyperintensities of presumed vascular origin: a population‐based study in rural Ecuador (The Atahualpa Project)
ConclusionsPrevalence and correlates of white matter hyperintensities in elders living in rural Ecuador is almost comparable with that reported from industrialized nations, reinforcing the concept that the burden of small vessel disease is on the rise in underserved Latin American populations.
Source: International Journal of Stroke - December 1, 2014 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Victor J. Del Brutto, Mauricio Zambrano, Julio Lama Tags: Research Source Type: research

Metabolic syndrome correlates poorly with cognitive performance in stroke-free community-dwelling older adults: a population-based, cross-sectional study in rural Ecuador.
CONCLUSIONS: This population-based study showed a poor correlation of metabolic syndrome with cognitive performance after adjusting for relevant confounders. Of the individual components of metabolic syndrome, only hypertriglyceridemia correlated with worse cognitive performance. PMID: 26142624 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - July 5, 2015 Category: Geriatrics Authors: Del Brutto OH, Mera RM, Zambrano M Tags: Aging Clin Exp Res Source Type: research

The association of ankle‐brachial index with silent cerebral small vessel disease: results of the Atahualpa Project
ConclusionsIn this population‐based study conducted in rural Ecuador, apparently healthy individuals aged ≥60 years with ankle‐brachial index values ≤0·90 and ≥1·4 are almost four times more likely to have a silent lacunar infarct. Ankle‐brachial index screening might allow recognition of asymptomatic people who need further investigation and preventive therapy.
Source: International Journal of Stroke - January 12, 2015 Category: Neurology Authors: Oscar H. Del Brutto, Mark J. Sedler, Robertino M. Mera, Julio Lama, Jadry A. Gruen, Kelsie J. Phelan, Elizabeth H. Cusick, Mauricio Zambrano, David L. Brown Tags: Research Source Type: research

Cost Effectiveness of Apixaban For Stroke Prevention In Non Valvular Atrial Fibrillation In The Ecuatorian Public Healthcare Sector
To assess the cost-effectiveness of apixaban for the prevention of stroke in patients with non valvular atrial fibrillation (NVAF) from the payer’s perspective of the Ministry of Public Healthcare in Ecuador (MPHE).
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: A. Rosado-Buzzo, M. Albuja, L. Garcia-Molliendo, G. Luna-Casas Source Type: research

Cerebrovascular correlates of vitamin D deficiency in older adults living near the Equator: results from the Atahualpa Project
This study shows an association of vitamin D deficiency with diffuse subcortical brain damage in older adults living in a tropical region. Lack of awareness of the importance of vitamin D deficiency might be one of the factors influencing the high prevalence of white matter hyperintensities of presumed vascular origin in underserved Latin American populations.
Source: International Journal of Stroke - August 28, 2015 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Jorge Macias, Gabriela Morales, Mauricio Zambrano Tags: Panorama Source Type: research