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Total 321 results found since Jan 2013.

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitabi...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Public stroke education: Current status worldwide and projects to increase awareness in the Czech Republic
Conclusion Educating adults about stroke is costly and its efficacy is either limited or not present. The promising solution is educating children at schools.
Source: Cor et Vasa - February 23, 2017 Category: Cardiology Source Type: research

Prevalence of spasticity in patients suffering from ischemic stroke in the internal carotid artery territory - the results of interim analysis of the national registry SONAR (P4.313)
Conclusions:Spasticity was noted in 44.9 % patients with neurological deficit due to first-ever stroke in carotid territory during the first 10 days after stroke onset. Severe spasticity was rare.Study Supported by:This study was conducted on an academic basis and supported by the AZV of the Ministry of Health of the Czech Republic no. 15-31921A; Ministry of Health of the Czech Republic MH CZ – DRO (FNOL, 00098892)–2016 and by a grant from the Internal Grant Agency of Palacky University IGA UP LF-2016-017.Disclosure: Dr. Kanovsky has received research support from Merz. Dr. Dornák has nothing to disclose...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kaňovsky, P., Dorňak, T., Maria, J., Jech, R., Bareš, M., Dušek, L., Mužik, J., Hoskovcova, M., Konvalinkova, R., Srp, M., Řiha, M., Navratilova, D., Otruba, P. Tags: Neuroepidemiology: Cerebrovascular Disease II Source Type: research

Predictors of Short- and Long-Term Mortality in Ischemic Stroke: A Community-Based Study in Brno, Czech Republic
Conclusions: Our study is the first to report data on short- and long-term mortality rates and their predictors in patients hospitalized with IS in the Czech population. Our results indicate that mortality rates and predictors of mortality are consistent with those reported in studies from other populations throughout the world.Cerebrovasc Dis
Source: Cerebrovascular Diseases - November 17, 2021 Category: Neurology Source Type: research

The changes of secondary prevention practice in Czech post-stroke patients between 2007 and 2012/13
In conclusion, despite substantial improvement in acute management, clinical practice in secondary prevention in post-stroke patients remains far from being optimal.
Source: Cor et Vasa - February 23, 2016 Category: Cardiology Source Type: research

Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies
AbstractOxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of myocardial infarction (MI) and stroke. However, associations of biomarkers of oxidative stress with MI and stroke have not yet been addressed in large cohort studies. A nested case –control design was applied in four population-based cohort studies from Germany, Czech Republic, Poland and Lithuania. Derivatives of reactive oxygen metabolites (d-ROMs) levels, as a proxy for the reactive oxygen species burden, and total thiol levels (TTL), as a proxy for the reductive capacity , were measured in baseline serum samples of ...
Source: European Journal of Epidemiology - November 7, 2018 Category: Epidemiology Source Type: research

Subclinical atrial fibrillation - what is the risk of stroke?
Authors: Plasek J, Taborsky M Abstract Atrial fibrillation is the most common arrhythmia and as such, it has become a significant public health issue due to its impact on patient morbidity and mortality. The prevalence of atrial fibrillation (AF) almost doubled in the last decade, being currently 2% in unselected patient populations. Its occurrence varies with age (present in almost 20% of octogenarians) and concomitant diseases. The most prevalent concomitant diseases are hypertension, diabetes, heart failure, renal failure, and cognitive decline. Cognitive decline or stroke may be actually the first manifestation...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 12, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Content Analysis of Stroke Teleconsultation Recordings in the Moravian-Silesian Region, Czech Republic
Conclusion: Teleconsultations between paramedics and hospital-based neurologists are not time-consuming. Stroke onset time and severity of neurological deficit are consistently communicated, however other important information such as comorbidities, premorbid disability, and anticoagulation status are reported inconsistently.
Source: Frontiers in Neurology - September 9, 2021 Category: Neurology Source Type: research

Functional differences in upper limb movement after early and chronic stroke based on kinematic motion indicators.
CONCLUSION: The variables used in the study showed applicability in assessing kinematic parameters in both the early and chronic period after stroke. PMID: 30338767 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - October 20, 2018 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Paroxysmal atrial fibrillation in young cryptogenic ischemic stroke: A 3-week ECG Holter monitoring study.
CONCLUSIONS: PAF was detected in 9.5% of young CIS patients and 3-weeks ECG Holter monitoring increased the detection rate. PMID: 25916280 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - June 3, 2015 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Prospective randomized placebo-controlled double-blind clinical study comparing the safety and efficacy of heparin and nadroparin administered in therapeutic doses to placebo in acute ischemic stroke - pilot study.
CONCLUSION: The results show that the treatment with heparin and nadroparin is safe and effective. TRIAL REGISTRATION: Trial is registered in ClinicalTrials.gov: NCT01862978. PMID: 27646496 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 22, 2016 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Electrical stimulation of hyoid muscles in post-stroke dysphagia.
CONCLUSION: Electrical stimulation of suprahyoid muscles significantly reduced the duration of the oral and pharyngeal phases: in the post-stroke patients with dysphagia used in this study. The result is improved swallowing. This is a recently recommended approach and your study confirms its efficacy. PMID: 29097820 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 5, 2017 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

New Prehospital Triage for Stroke Patients Significantly Reduces Transport Time of EVT Patients Without Delaying IVT
Conclusions: The new prehospital triage has yielded shorter OGTs for EVT patients. No changes were found in the onset-to-needle time for IVT-treated patients, or in the clinical outcome at 3 months after stroke onset.
Source: Frontiers in Neurology - June 11, 2021 Category: Neurology Source Type: research

Cost and cost-effectiveness of early inpatient rehabilitation after stroke varies with initial disability: the Czech Republic perspective
The purpose of this prospective study was to determine whether the cost and cost-effectiveness of early rehabilitation after stroke are associated with the degree of initial disability. The data for cost calculations were collected by the bottom-up (micro-costing) method alongside the standard inpatient care. The total sample included 87 patients who were transferred from acute care to early rehabilitation unit of three participating stroke centers at the median time poststroke of 11 days (range 4–69 days). The study was pragmatic so that all hospitals followed their standard therapeutic procedures. For each patient,...
Source: International Journal of Rehabilitation Research - November 12, 2020 Category: Rehabilitation Tags: Original Articles Source Type: research

Endovascular Treatment of Acute Ischemic Stroke —The Results of the METRICS Study (Mechanical Thrombectomy Quality Indicators Study in Czech Stroke Centers)
Rigorous and regular evaluation of defined quality indicators is crucial for further improvement of both technical and clinical results after mechanical thrombectomy (MT) for acute ischemic stroke. With the recent international multi-society consensus quality indicators, we aimed to assess whether centers in the Czech Republic performing endovascular treatment of acute ischemic stroke have met these recommendations.
Source: Journal of Vascular Surgery - March 17, 2023 Category: Surgery Authors: Martin K öcher, Daniel Šaňák, Jana Zapletalova Source Type: research