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Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. The relationship between NTFs and glia is crucial for both the developing and adult brain. While some of these factors, such as NT-3 and CNTF, have highly potent effects on gliogenesis, others like BDNF and GDNF, are important for glia-mediated synapse formation. Neurotrophic factors play significant roles during neurodegenerative disorders. In many cases, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Voodoo Medicine: Time To Stop
The world's most celebrated athlete standing on the podium in Rio in honor of receiving yet another gold medal has something important in common with your lazy uncle throwing back a cold one in his Barcalounger. Yes, swimming powerhouse Michael Phelps, purple-spotted from cupping therapy, and your slovenly relative with a beer gut both share a bond -- a weakness in succumbing to the allure of voodoo medicine. Modern-day snake oil salesmen hawking quick cures and TV doctors peddling the latest diet miracle with blatantly ridiculous claims are everywhere on the tube, social media, the supermarket and old-fashioned billboards...
Source: Science - The Huffington Post - August 12, 2016 Category: Science Source Type: news

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research

Inflammatory hypertrophic cauda equina following intrathecal neural stem cell injection
We describe a woman who presented with progressive bilateral leg pain, numbness, and gait difficulties. A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas 1 year prior to onset of symptoms. Imaging showed marked enlargement of lumbosacral roots of the cauda equina, which was not seen prior to stem cell treatment. Electrodiagnostic studies confirmed chronic multiple lumbosacral radiculopathies. Biopsy of a lumbar dorsal sensory root showed myelinated fiber degeneration and loss, with endoneurial inflammation. The hypertrophic inflammatory ca...
Source: Muscle and Nerve - June 1, 2013 Category: Internal Medicine Authors: Richard W. Hurst, Jonathan M. Morris, P James B Dyck, E. Peter Bosch, Ronald K. Reeves Tags: Case of the Month Source Type: research

Medical management of critical limb ischaemia: where do we stand today?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - June 26, 2013 Category: Internal Medicine Authors: Matthew A. Lambert, Jill J. F. Belch Tags: Review Source Type: research

Inflammatory hypertrophic cauda equina syndrome following intrathecal neural stem cell injection
Conclusions: Safety of intrathecal stem cell treatments is not routinely regulated in commercial overseas stem cell facilities. We wish to bring this potential complication to the attention of health care providers. Muscle Nerve, 2013
Source: Muscle and Nerve - June 26, 2013 Category: Internal Medicine Authors: Richard W. Hurst, E. Peter Bosch, Jonathan M. Morris, P. James B. Dyck, Ronald K. Reeves Tags: Case of the Month Source Type: research

New heart op could save 'thousands of lives'
Conclusion This was a well-designed study which showed that over the course of two years, the risk of another non-fatal or fatal heart attack is reduced in heart attack patients who have preventive stents inserted in narrowed arteries at the same time as a procedure to insert stents into the blocked coronary artery that caused their heart attack. However, an important point to note is that the study results do not apply to all patients who have had a heart attack. The study only looked at the group of patients who had a specific type of heart attack – a STEMI – and needed an emergency stent placement operation. ...
Source: NHS News Feed - September 3, 2013 Category: Consumer Health News Tags: Heart/lungs Genetics/stem cells Source Type: news

Can pain be 'switched off'?
Conclusion This study adds to the scientific knowledge about which genes play a role in pain response. The study shows an association between a low pain threshold and reduced gene expression in nine locations on the DNA. This means that researchers have found changes not only in genes already known to be involved in pain response, but in other genes as well. As the study was conducted in identical twins, the researchers have also been able to identify that the gene responses started off the same but have become different for some reason. The study shows that there is an association, but it does not provide information abo...
Source: NHS News Feed - February 5, 2014 Category: Consumer Health News Tags: Genetics/stem cells Medical practice Source Type: news

Stress 'causes damage to the heart,' study finds
Conclusion This research investigates the widely held perceived wisdom that psychological stress is associated with coronary heart disease. It found 29 medical residents working in a stressful intensive care unit setting had increased levels of white blood cells, which form part of the immune system. The researchers also found exposing mice to chronic stress similarly increased their levels of certain white blood cells. When they examined the bone marrow of stressed mice, they found this increase in the number of white blood cells seemed to be mediated by an increase in the activity of hematopoietic stem cells, which prod...
Source: NHS News Feed - June 23, 2014 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Mental health Source Type: news

Hematopoietic Stem Cell Transplantation for Sickle Cell Disease: State of the Science
This article is protected by copyright. All rights reserved.
Source: European Journal of Haematology - September 1, 2014 Category: Hematology Authors: Julie‐An Talano, Mitchell S. Cairo Tags: Review Article Source Type: research

Smoothing the crescent curve: sickle cell disease.
Authors: Talano JA, Cairo MS Abstract Sickle cell disease (SCD) is an inherited disorder secondary to a point mutation at the sixth position of the beta chain of human hemoglobin that results in the replacement of valine for glutamic acid. This recessive genetic abnormality precipitates the polymerization of the deoxygenated form of hemoglobin S that induces a major distortion of red blood cells (sickle red blood cells), which decreases sickle red blood cell deformability, leading to chronic hemolysis and vasoocclusion. These processes can result in severe complications, including chronic pain, end organ dysfunctio...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

No pain, no gain: Lack of exercise obstructs neurogenesis.
In this study, we discussed how immobilization-induced disuse atrophy, using the hindlimb suspension model, affects neurogenesis in rats. The overarching hypothesis is that immobilization suppresses neurogenesis by reducing the circulating growth or trophic factors, such as vascular endothelial growth factor or brain-derived neurotrophic factor. That immobilization alters neurogenesis and stem cell differentiation in the CNS requires characterization of the stem cell microenvironment by examining the trophic and growth factors, as well as stressrelated proteins that have been implicated in exercise-induced neurogenesis. Al...
Source: Cell Transplantation - March 24, 2015 Category: Cytology Authors: Watson N, Ji X, Yasuhara T, Date I, Kaneko Y, Tajiri N, Borlongan CV Tags: Cell Transplant Source Type: research

Cervical epidural hematoma in a healthy donor presenting stroke mimic symptoms: a rare adverse event following peripheral blood stem cell apheresis
This report is the first case of cervical epidural hematoma in a healthy donor who underwent peripheral blood stem cell apheresis and presented symptoms confusingly similar to those of brain infarction.
Source: Japanese Journal of Clinical Oncology - May 28, 2015 Category: Cancer & Oncology Authors: Terabe, S., Nishiwaki, S., Koyama, D., Okuno, S., Harada, Y., Tomita, H., Yoshihara, H., Iwasaki, T., Sugiura, I. Tags: Case Report Source Type: research

Glioproliferative Lesion of the Spinal Cord Derived from Intrathecal Administration of Stem Cells (P4.234)
CONCLUSIONS: Unregulated intrathecal SCT can cause devastating complications. This patient’s highly proliferative neoplasm developing from pluripotent stem cells supports the ideological shift to employ more differentiated cells in future SCT research.Disclosure: Dr. Saad has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Cagney has nothing to disclose. Dr. Chavakula has nothing to disclose. Dr. Guleria has nothing to disclose. Dr. Aizer has nothing to disclose. Dr. Ligon has nothing to disclose. Dr. Chi has nothing to disclose. Dr. Berkowitz has received royalty payments from Clinical Pathophysiology M...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Saad, M., Miller, M., Cagney, D., Chavakula, V., Guleria, I., Aizer, A., Ligon, K., Chi, J., Berkowitz, A. Tags: Neuro-oncology: Neurologic Complications of Cancer Source Type: research

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