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Patient Care Falters as COVID-19 Devastates L.A. County (CA) Hospitals
Soumya Karlamangla, Rong-Gong Lin II, Luke Money Los Angeles Times (MCT) Los Angeles County’s healthcare system was buckling Wednesday under the unprecedented surge of COVID-19 patients, with bodies piling up at morgues and medical professionals resorting to increasingly desperate measures as they brace for conditions to worsen in the coming weeks. With hospitals overwhelmed by patients and no outlet valve available, doctors, nurses and paramedics are being forced to make wrenching choices about who gets care and at what level. “No one would believe this is in the United States,” ...
Source: JEMS Administration and Leadership - December 31, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Coronavirus News News Feed California EMS Hospital Paramedic Source Type: news

Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic Approach
The novel coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a wide range of manifestations. In this regard, growing evidence is focusing on COVID-19 neurological associations; however, there is a lack of established pathophysiological mechanisms and related treatments. Accordingly, a comprehensive review was conducted, using electronic databases, including PubMed, Scopus, Web of Science, and Cochrane, along with the author’s expertize in COVID-19 associated neuronal signaling pathways. Besides, potential phytochemicals have been provided against neurological signs...
Source: Frontiers in Pharmacology - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Neurological associations of SARS-CoV-2 infection: A Systematic Review.
Abstract BACKGROUND: The current ongoing COVID-19 pandemic has compelled us to scrutinize major outbreaks in the past two decades, severe acute respiratory syndrome (SARS), in 2002, and Middle East respiratory syndrome (MERS), in 2012. We aimed to assess the associated neurological manifestations with SARS CoV-2 infection. METHODS: In this systematic review, a search was carried out by key-electronic databases, controlled vocabulary, and indexing of trials to evaluate the available pertinent studies which included both medical subject headings (MeSH) and advance electronic databases comprising of PubMed, Emba...
Source: CNS and Neurological Disorders Drug Targets - February 16, 2021 Category: Drugs & Pharmacology Authors: Javed A Tags: CNS Neurol Disord Drug Targets Source Type: research

Neurological associations of SARS-CoV-2 infection: A Systematic Review
CNS Neurol Disord Drug Targets. 2021 Feb 16. doi: 10.2174/1871527320666210216121211. Online ahead of print.ABSTRACTBACKGROUND: The current ongoing COVID-19 pandemic has compelled us to scrutinize major outbreaks in the past two decades, severe acute respiratory syndrome (SARS), in 2002, and Middle East respiratory syndrome (MERS), in 2012. We aimed to assess the associated neurological manifestations with SARS CoV-2 infection.METHODS: In this systematic review, a search was carried out by key-electronic databases, controlled vocabulary, and indexing of trials to evaluate the available pertinent studies which included both ...
Source: CNS and Neurological Disorders Drug Targets - February 17, 2021 Category: Drugs & Pharmacology Authors: Amaan Javed Source Type: research

COVID-19 long-haulers experience chest pain, blood clot complications, weeks after recovery: Study
Some long-haul COVID-19 patients experience stroke, chest pain, and blood clot-related complications weeks after recovery, according to a review of studies by an interdisciplinary team of more than 30 experts.
Source: The Economic Times - March 23, 2021 Category: Consumer Health News Source Type: news

Viruses, Vol. 13, Pages 700: Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms
id J Alzahrani Aristóteles Góes-Neto Vasco Azevedo Preetam Ghosh Debmalya Barh The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study post-COVID (i.e., short-term) and long-COVID (i.e., long-term) effects, specifically as local and systemic pathophysiological outcomes of other coronavirus-related diseases (such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS)) were well-cataloged. We conducted a comprehensive review of adverse post-COVID health outcomes and potential long-COV...
Source: Viruses - April 18, 2021 Category: Virology Authors: Bruno Silva Silva Andrade S érgio Siqueira Wagner Rodrigues de Assis de Assis Soares Fernanda de Souza de Souza Rangel Naiane Oliveira Santos Andria dos Santos dos Santos Freitas Priscila Ribeiro da Ribeiro da Silveira Sandeep Tiwari Khalid J Alzahrani A Tags: Review Source Type: research

Demyelination as a result of an immune response in patients with COVID-19
AbstractThe coronavirus disease of 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), that already appeared as a global pandemic. Presentation of the disease often includes upper respiratory symptoms like dry cough, dyspnea, chest pain, and rhinorrhea that can develop to respiratory failure, needing intubation. Furthermore, the occurrence of acute and subacute neurological manifestations such as stroke, encephalitis, headache, and seizures are frequently stated in patients with COVID-19. One of the reported neurological complications of severe COVID-19 is the demolition of the my...
Source: Acta Neurologica Belgica - May 2, 2021 Category: Neurology Source Type: research

Migraine and neuroinflammation: the inflammasome perspective
ConclusionNeuroinflammatory pathways, specifically those involving inflammasome proteins, seem promising candidates as treatment targets, and perhaps even biomarkers, in migraine.
Source: The Journal of Headache and Pain - June 10, 2021 Category: Neurology Source Type: research

Pulmonary Embolism and Cardiac Tamponade in Critical Care Patients with COVID-19; Telemedicine's Role in Developing Countries: Case Reports and Literature Review
CONCLUSIONS: During admission, both patients had sudden deterioration characterized by oxygen desaturation and hypotension necessitating inotropic support. As a result, for both patients, bedside echocardiography was performed by the attending intensivist. Echocardiographic findings showed cardiac tamponade and acute pulmonary embolism, respectively, which were confirmed by a cardiologist through telemedicine technology. Proper emergency management was initiated, and both patients recovered well. Limited bedside transthoracic echocardiography had a front-line impact on the treatment and outcome of the two patients with COV...
Source: Pain Physician - August 2, 2021 Category: Anesthesiology Authors: Islam Mohammed Sheata Scott Richard Smith Heba Kamel Giustino Varrassi Farnad Imani Abdolreza Dayani Dariusz Myrcik Ivan Urits Omar Viswanath Sameh Salem Taha Source Type: research

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021
AbstractAn increasing interest in a healthy lifestyle raises questions about optimal body weight. Evidently, it should be clearly discriminated between the standardised “normal” body weight and individually optimal weight. To this end, the basic principle of personalised medicine “one size does not fit all” has to be applied. Contextually, “normal” but e.g. borderline body mass index might be optimal for one person but apparently suboptimal for another one strongly depending on the individual genetic predisposition, geographic origin, cultural and nutritional habits and relevant lifestyle parameters—all inclu...
Source: EPMA Journal - August 17, 2021 Category: International Medicine & Public Health Source Type: research

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