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Total 387 results found since Jan 2013.

Predictors of Thrombolysis Administration in Mild Stroke Clinical Sciences
Conclusions—Mild acutely presenting stroke patients are more likely to receive thrombolysis if they are young, white, or Hispanic and arrive early to the hospital with more severe neurological presentation. Identification of predictors of thrombolysis is important in design of future studies to assess the use of thrombolysis for mild stroke.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Negar Asdaghi, Kefeng Wang, Maria A. Ciliberti-Vargas, Carolina Marinovic Gutierrez, Sebastian Koch, Hannah Gardener, Chuanhui Dong, David Z. Rose, Enid J. Garcia, W. Scott Burgin, Juan Carlos Zevallos, Tatjana Rundek, Ralph L. Sacco, Jose G. Romano Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Recanalization Modulates Association Between Blood Pressure and Functional Outcome in Acute Ischemic Stroke Clinical Sciences
Conclusions— Systemic BP in the first 24 hours after ischemic stroke influences 3-month clinical outcome. This association is dependent on the revascularization status.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Martins, A. I., Sargento-Freitas, J., Silva, F., Jesus-Ribeiro, J., Correia, I., Gomes, J. P., Aguiar-Goncalves, M., Cardoso, L., Machado, C., Rodrigues, B., Santo, G. C., Cunha, L. Tags: High Blood Pressure, Hypertension, Cerebrovascular Procedures, Ischemic Stroke Clinical Sciences Source Type: research

Clinical Utility of Electronic Alberta Stroke Program Early Computed Tomography Score Software in the ENCHANTED Trial Database Clinical Sciences
Background and Purpose—Clinical utility of electronic Alberta Stroke Program Early CT Score (e-ASPECTS), an automated system for quantifying signs of infarction, was evaluated in a large database of thrombolyzed patients with acute ischemic stroke.Methods—All baseline noncontrast computed tomographic scans of patients with anterior circulation acute ischemic stroke who participated in the alteplase dose arm of the randomized controlled trial ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) were reviewed; poor quality and large (>6 mm) slice thickness were excluded. Included scans had e-ASPECTS...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Simon Nagel, Xia Wang, Cheryl Carcel, Thompson Robinson, Richard I. Lindley, John Chalmers, Craig S. Anderson Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Cause-specific Mortality after Stroke: Relation to Age, Sex, Stroke Severity, and Risk Factors in a 10-Year Follow-up Study
We investigated cause-specific mortality in relation to age, sex, stroke severity, and cardiovascular risk factor profile in the Copenhagen Stroke Study cohort with 10 years of follow-up. In a Copenhagen community, all patients admitted to the hospital with stroke during 1992-1993 (n = 988) were registered on admission. Evaluation included stroke severity, computed tomography scan, and a cardiovascular risk profile. Cause of death within 10 years according to death certificate information was classified as stroke, heart/arterial disease, or nonvascular disease. Competing-risks analyses were performed by cause-specific Co...
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2012 Category: Neurology Authors: Ulla Brasch Mogensen, Tom Skyhøj Olsen, Klaus Kaae Andersen, Thomas Alexander Gerds Tags: Original Articles Source Type: research

Current status of acute stroke management in Korea: a report on a multicenter, comprehensive acute stroke registry
There are limited data on the utilization of diagnostics and the variation of treatments at the national level in acute stroke care. Clinical Research Center for Stroke – 5th division stroke registry aimed to describe stroke statistics and quality of care in Korea and to implement quality indicators. Clinical Research Center for Stroke – 5th division registry was established in April 2008 and covers pretreatment demographics, medical and stroke severity measures, diagnostic evaluation, hyperacute revascularization, in‐hospital management, discharge disposition, quality indicators, and long‐term functional outcomes....
Source: International Journal of Stroke - November 21, 2013 Category: Neurology Authors: Beom Joon Kim, Moon‐Ku Han, Tai Hwan Park, Sang‐Soon Park, Kyung Bok Lee, Byung‐Chul Lee, Kyung‐Ho Yu, Jae Kwan Cha, Dae‐Hyun Kim, Jun Lee, Soo Joo Lee, Youngchai Ko, Jong‐Moo Park, Kyusik Kang, Yong‐Jin Cho, Keun‐Sik Hong, Ki‐Hyun Cho, Tags: Panorama Source Type: research

Population-Based Case-Control Study of White Matter Changes on Brain Imaging in Transient Ischemic Attack and Ischemic Stroke Clinical Sciences
Conclusions— In contrast to small vessel ischemic events, WMC were not independently associated with other pathogenic subtypes, suggesting that WMC are unlikely to be an independent risk factor for nonsmall vessel events.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Li, L., Simoni, M., Kuker, W., Schulz, U. G., Christie, S., Wilcock, G. K., Rothwell, P. M. Tags: Computerized tomography and Magnetic Resonance Imaging, Epidemiology Clinical Sciences Source Type: research

The Detrimental Effect of Aging on Leptomeningeal Collaterals in Ischemic Stroke
Conclusion: Our findings show that there is a significant interplay between patient age and adequacy of leptomeningeal collateral circulation in patients with proximal MCA occlusion. The relationship could contribute to adverse tissue outcome and thereby to unfavorable clinical outcome observed in elderly patients with ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2013 Category: Neurology Authors: Ethem Murat Arsava, Atay Vural, Erhan Akpinar, Rahsan Gocmen, Seray Akcalar, Kader K. Oguz, Mehmet Akif Topcuoglu Tags: Original Articles Source Type: research

Retinal and Ophthalmic Artery Studies in Ischemic Stroke Patients Using Fundus Photography and Transcranial Doppler Methods (P4.252)
Conclusions:Our study in a robust sample of non-severe stroke patients showed that abnormal retinal AVR is strongly associated with IS patients even after accounting for traditional risk factors. OA-TCD studies, on the other hand, did not have significant associations with stroke group.Disclosure: Dr. Patil has nothing to disclose. Dr. Narayan has nothing to disclose. Dr. Babu K has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Patil, K., Narayan, S., Babu, K. R. Tags: Acute and Diagnostic Imaging in Ischemic Stroke and TIA Source Type: research

Internal Cerebral Vein Asymmetry on Follow-up Brain Computed Tomography after Intravenous Thrombolysis in Acute Anterior Circulation Ischemic Stroke Is Associated with Poor Outcome
Background: Identifying early predictors of functional outcome after acute ischemic stroke (AIS) is important for planning rehabilitation strategies. Internal cerebral veins (ICV) drain deep parts of brain, run parallel to each other, and consistently seen on computed tomography angiography (CTA). Even minor asymmetry in their filling can be identified. We hypothesized that venous drainage would be impaired in patients with acute occlusion of internal carotid artery or middle cerebral artery. Because systemic thrombolysis can alter the vascular findings, we evaluated the relationship between ICV asymmetry on follow-up CTA ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Vijay K. Sharma, Leonard L.L. Yeo, Hock L. Teoh, Liang Shen, Bernard P.L. Chan, Raymond C. Seet, Aftab Ahmad, Vincent F. Chong, Prakash R. Paliwal Tags: Original Articles Source Type: research

Early and Continuous Neurologic Improvements after Intravenous Thrombolysis Are Strong Predictors of Favorable Long-term Outcomes in Acute Ischemic Stroke
Background: Intravenously administered tissue plasminogen activator (IV tPA) remains the only approved therapeutic agent for arterial recanalization in acute ischemic stroke (AIS). Considerable proportion of AIS patients demonstrate changes in their neurologic status within the first 24 hours of intravenous thrombolysis with IV tPA. However, there are little available data on the course of clinical recovery in subacute 2- to 24-hour window and its impact. We evaluated whether neurologic improvement at 2 and 24 hours after IV tPA bolus can predict functional outcomes in AIS patients at 3 months.Methods: Data for consecutive...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Leonard LL. Yeo, Prakash Paliwal, Hock L. Teoh, Raymond C. Seet, Bernard PL. Chan, Benjamin Wakerley, Shen Liang, Rahul Rathakrishnan, Vincent F. Chong, Eric YS. Ting, Vijay K. Sharma Tags: Original Articles Source Type: research

International Issues: Acute ischemic stroke: An international experience
Mr. Q, a 72-year-old right-handed man with hypertension, hyperlipidemia, recurrent angina, and a 30 pack-year smoking history is a retired scientist living in the United States with his wife. He recently visited his native country, Ukraine, for the first time in almost 30 years. After an emotional day with family members, he returned home and suddenly became diaphoretic and weak, and ultimately lost consciousness. His wife drove him to the nearest open medical clinic. Because it was severely underresourced, he was then emergently taken by ambulance to a larger hospital 6 hours away. He regained consciousness by the time he...
Source: Neurology - November 3, 2014 Category: Neurology Authors: Colling, M., Lioutas, V.-A., Krishnan, V. Tags: Cost effectiveness/economic, Outcome research, Quality of life, Stroke prevention, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Effective ADAPT Thrombectomy in a Patient with Acute Stroke due to Cardiac Papillary Elastofibroma: Histological Thrombus Confirmation
A 75-year-old man with hypertension and atrial fibrillation was admitted to our emergency room with right-sided hemiplegia and complete aphasia (National Institutes of Health Stroke Scale [NIHSS] score  = 18). A noncontrast computed tomography scan showed a slight hypodensity in the left insular region and a bright hyperdense sign in the M1 tract of the left middle cerebral artery (MCA). Angio-CT confirmed an occlusion of the M1 tract of the MCA. Magnetic resonance diffusion-weighted imaging/p erfusion-weighted imaging was obtained and revealed a mismatch in the left parietal cortical region.
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2016 Category: Neurology Authors: Francesco Biraschi, Francesco Diana, Francesco Alesini, Giulio Guidetti, Simone Peschillo Tags: Case Studies Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Frequency of Hemorrhage on Follow Up Imaging in Stroke Patients Treated With rt-PA Depending on Clinical Course
Conclusions: Frequency of hemorrhagic transformation in Routine follow-up brain imaging and consecutive changes in therapeutic management were different depending on clinical course measured by NHISS score. Introduction Brain imaging 24–36 h after systemic thrombolysis for acute ischemic stroke is recommended in American Stroke Association and European Stroke Organization guidelines (1, 2). Brain imaging is performed to detect secondary bleeding or hemorrhagic transformation in order to adapt medical stroke prevention if necessary. Guideline recommendations are based on the results of the first study on rt-PA...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research