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Condition: Diabetes
Therapy: Statin Therapy

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Total 723 results found since Jan 2013.

Statin use linked to small increase in cataracts risk
Conclusion This research using a large cohort of people from a military healthcare system finds that overall, use of statins for over 90 days was associated with a slight increase in a person’s risk of developing cataracts. Further analyses suggested that the risk was higher among people who did not have any additional diseases. From this the researchers suggest that risk may be higher when statins are given for what is called primary prevention, i.e. given to people with risk factors for cardiovascular disease but who have not yet suffered any cardiovascular disease events such as a heart attack or stroke. The study h...
Source: NHS News Feed - September 20, 2013 Category: Consumer Health News Tags: Medication Older people Heart/lungs Source Type: news

Statins are 'safe, effective and should be used more widely'
Conclusion This study reviews evidence from randomised controlled trials (RCTs) and observational studies to better evaluate the effects and safety of statin therapy. It provides valuable data on the size of the benefits compared with the risks, informing a topic that has had much media coverage in recent times. The researchers highlight that the benefits of statin therapy for people at risk of cardiovascular disease events far outweigh any possible side effects. But it is still for a doctor and their patient to come to a conclusion about what the best treatment for them may be. If you have been prescribed a statin, it...
Source: NHS News Feed - September 9, 2016 Category: Consumer Health News Tags: QA articles Medication Heart/lungs Source Type: news

Interaction of incidental microbleeds and prior use of antithrombotics with early hemorrhagic transformation: Causative or protective ?
Conclusion: Presence of incidental CMBs was not associated with increased risk for early HT of an ischemic stroke. Interestingly, the prior intake of antiplatelets was found to be protective against HT of ischemic stroke.
Source: Annals of Indian Academy of Neurology - November 21, 2016 Category: Neurology Authors: Konark Malhotra Monica Khunger Bichun Ouyang David S Liebeskind Yousef M Mohammad Source Type: research

Statin Underuse and Low Prevalence of LDL-C Control Among U.S. Adults at High Risk of Coronary Heart Disease.
CONCLUSIONS:: These data suggest that many people with high CHD risk, especially those with an FRS >20%, do not receive guideline-concordant lipid-lowering therapy and do not achieve an LDL-C <100 mg/dL. PMID: 24892511 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - June 2, 2014 Category: Journals (General) Authors: Gamboa CM, Safford MM, Levitan EB, Mann DM, Yun H, Glasser SP, Woolley JM, Rosenson R, Farkouh M, Muntner P Tags: Am J Med Sci Source Type: research

Comparative effectiveness of cardioprotective drugs in elderly individuals with type 2 diabetes
ConclusionThe benefit of cardioprotective drugs in primary prevention was not clear in this cohort of elderly individuals with type 2 diabetes. A short duration of exposure to these drugs might explain the lack of benefit.
Source: International Journal of Clinical Practice - October 31, 2014 Category: Internal Medicine Authors: C. Sirois, J. Moisan, P. Poirier, J.‐P. Grégoire Tags: Original Paper Source Type: research

EMPA-REG and Other Cardiovascular Outcome Trials of Glucose-lowering Agents: Implications for Future Treatment Strategies in Type 2 Diabetes Mellitus.
Abstract During the last decade, the armamentarium for glucose-lowering drugs has increased enormously by the development of DPP-4 inhibitors, GLP-1 receptor agonists and SGLT2 inhibitors, allowing individualization of antidiabetic therapy for patients with type 2 diabetes (T2DM). Some combinations can now be used without an increased risk for severe hypoglycemia and weight gain. Following a request of the US Food and Drug Administration, many large cardiovascular (CV) outcome studies have been performed in patients with longstanding disease and established CV disease. In the majority of CV outcome studies, CV ris...
Source: Clinical Therapeutics - May 18, 2016 Category: Drugs & Pharmacology Authors: Schernthaner G, Schernthaner-Reiter MH, Schernthaner GH Tags: Clin Ther Source Type: research

Higher Non-High-Density Lipoprotein Cholesterol Was Higher Associated With Cardiovascular Disease Comparing Higher LDL-C in Nine Years Follow Up: Cohort Study
CONCLUSION: In our large population study, higher non-HDL-C levels were associated with CVD than LDL-C levels.PMID:37265846 | PMC:PMC10232221 | DOI:10.12997/jla.2023.12.2.164
Source: Atherosclerosis - June 2, 2023 Category: Cardiology Authors: Sangmo Hong Kyungdo Han Jung Hwan Park Sung Hoon Yu Chang Beom Lee Dong Sun Kim Source Type: research

Risk factors for primary prevention of cardiovascular disease and risk reduction by lipid control: the OMEGA study risk factor sub-analysis.
In conclusion, some risk factors for CVD in hypertensive patients being treated with antihypertensive drugs with no history of CVD differed between CHD and stroke. These results suggest the importance of managing dyslipidemia with a statin for primary prevention of CHD, as well as the importance of hypertension therapy. PMID: 23865387 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Hypertension - July 18, 2013 Category: Cardiology Authors: Teramoto T, Kawamori R, Miyazaki S, Teramukai S, Mori Y, Okuda Y, Hiramatsu K, the OMEGA Study Group Tags: Clin Exp Hypertens Source Type: research

'More adults should be taking statins,' says NICE
Conclusion Despite somewhat hysterical media coverage to the contrary ("millions more to be given statins," according to the Daily Express), nobody will be forced to take statins. If your GP does recommend statins, you should ask them to explain the benefits and risks for you personally of starting statin treatment. You may want to find out more about statins before making up your mind – the NHS Choices Health A-Z information on statins is a good place to start. If you do experience troublesome side effects while taking statins, contact your GP or the doctor in charge of your care. It could be the case that a...
Source: NHS News Feed - July 18, 2014 Category: Consumer Health News Tags: Heart/lungs Medication QA articles Source Type: news

Are patients with carotid stenosis receiving optimal medical therapy? (I2-1A)
Conclusion: Despite the presence of established large vessel atherosclerosis, a sizable proportion of patients reported that they were not receiving statin therapy or aspirin. Intensification of "real world" medical therapy will be important to reduce stroke rates and improve long-term survival.Disclosure: Dr. Koch has nothing to disclose. Dr. Chaturvedi has received personal compensation for activities with Genentech, Inc., Abbott Vascular, Boehringer-Ingelheim, WL Gore, and Merck. Dr. Chaturvedi has received personal compensation in an editorial capacity for NEJM Journal Watch Neurology. Dr. Romano has received personal ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Koch, S., Chaturvedi, S., Romano, J. Tags: Management of Asymptomatic Cerebrovascular Lesions Data Blitz Presentations Source Type: research

Are patients with carotid stenosis receiving optimal medical therapy? (P2.265)
Conclusion: Despite the presence of established large vessel atherosclerosis, a sizable proportion of patients reported that they were not receiving statin therapy or aspirin. Intensification of "real world" medical therapy will be important to reduce stroke rates and improve long-term survival.Disclosure: Dr. Koch has nothing to disclose. Dr. Chaturvedi has received personal compensation for activities with Genentech, Inc., Abbott Vascular, Boehringer-Ingelheim, WL Gore, and Merck. Dr. Chaturvedi has received personal compensation in an editorial capacity for NEJM Journal Watch Neurology. Dr. Romano has received personal ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Koch, S., Chaturvedi, S., Romano, J. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease and IMT Source Type: research

The Biggest Medical Stories You May Have Missed In 2015
SPECIAL FROM Next Avenue By Craig Bowron As we head into the New Year, let’s take a look back and see what lessons we should have learned from medical science in 2015. The New England Journal of Medicine’s publication Journal Watch provides physicians and other health care providers with expert analysis of the most recent medical research. Below is a brief synopsis of what the Journal Watch editors felt were the most important stories in general medicine for the year 2015. While you likely heard about a couple, others probably escaped your radar. Getting Aggressive with Strokes We’re familiar with the id...
Source: Science - The Huffington Post - January 15, 2016 Category: Science Source Type: news

Quality of Care for Patients with TIA with an Eye towards Quality Improvement: How Are We Doing? (P6.036)
Conclusion: Overall, care provided was guideline-concordant, but some patients with TIA are receiving suboptimal care, even among those admitted to a Stroke Center who are routinely admitted or seen by neurology. There are opportunities for improvement in TIA care, especially in statin treatment of eligible TIA patients.Disclosure: Dr. Kalaria has nothing to disclose. Dr. Flair has nothing to disclose. Dr. Cronin has nothing to disclose. Dr. Kittner has nothing to disclose. Dr. Phipps has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kalaria, C., Flair, Z., Cronin, C., Kittner, S., Phipps, M. Tags: Telestroke and Other Innovations and TIA Source Type: research

Real world adherence to oral anticoagulant in non-valvular atrial fibrillation patients in China.
CONCLUSION: Oral anticoagulation was significantly underused in NVAF patients in China. Age, sex, concurrent drug usage and disease history were associated factors. Improving warfarin adherence was promising to reduce ischemic stroke risk of NVAF patients. PMID: 29022745 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - October 13, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research