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Comparison of linear versus cubic assessment of left atrial size in the prediction of atrial fibrillation development in hypertrophic cardiomyopathy
Left atrial (LA) enlargement evaluated by echocardiography is a very strong predictor of cardiovascular (CV) outcomes such as atrial fibrillation (AF), stroke, congestive heart failure, and CV death in multiple clinical settings [1,2]. As a consequence, researchers have focused their attention on the best method to assess LA size. Left atrium is a thin-walled cardiac chamber directly exposed to left ventricular (LV) pressure during diastole, which represents its afterload. In particular, in hypertrophic cardiomyopathy (HCM), almost all patients have some degree of LV diastolic dysfunction.
Source: International Journal of Cardiology - March 16, 2016 Category: Cardiology Authors: Alessandra Giamundo, Grazia Canciello, Antonio Rapacciuolo, Francesca Musella, Gianluigi Savarese, Teresa Strisciuglio, Eugenio Stabile, Raffaele Izzo, Bruno Trimarco, Maria Angela Losi Source Type: research

Cystatin C and risk of atrial fibrillation in elderly hypertensive patients without chronic kidney disease
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, associated with increased risk of stroke, heart failure, and mortality [1]. Epidemiological evidence indicates that there is increased risk of AF in patients with chronic kidney disease (CKD) [2–4], while CKD is an independent risk factor for the development of AF [5–7]. Cystatin C (Cys-C) is a low molecular weight protein secreted by all nucleated cells at a constant rate. Cys-C can be freely filtrated through the glomerulus, and is almost completely reabsorbed and degraded in the proximal tubules [8].
Source: International Journal of Cardiology - March 23, 2016 Category: Cardiology Authors: Wenqian Wang, Ruyu Yuan, Panagiotis Korantzopoulos, Gang Xu, Xudan Cui, Guangping Li, Tong Liu Source Type: research

Letter: Conflicting and unresolved issue of the prognostic value of atrial fibrillation for chronic heart failure patients — Response
We would like to thank Bosseau and Donal for their interest in our paper, and agree with them about the increasing clinical importance of patients with concomitant atrial fibrillation (AF) and heart failure, regardless of ejection fraction [1]. Indeed, our analysis confirms poor prognosis in patients suffering from AF and heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). Although we identified higher crude rates of all-cause mortality with AF-HFrEF, incident stroke and heart failure admissions were similar to AF-HFpEF [2].
Source: International Journal of Cardiology - March 24, 2016 Category: Cardiology Authors: Dipak Kotecha Tags: Correspondence Source Type: research

Neural modulation for hypertension and heart failure
Hypertension (HTN) and heart failure (HF) have a significant global impact on health, and lead to increased morbidity and mortality. Despite recent advances in pharmacologic and device therapy for these conditions, there is a need for additional treatment modalities. Patients with sub-optimally treated HTN have increased risk for stroke, renal failure and heart failure. The outcome of HF patients remains poor despite modern pharmacological therapy and with established device therapies such as CRT and ICDs.
Source: International Journal of Cardiology - April 3, 2016 Category: Cardiology Authors: S. Smith, P. Rossignol, S. Willis, F. Zannad, R. Mentz, S. Pocock, J. Bisognano, Y. Nadim, N. Geller, S. Ruble, C. Linde Tags: Review Source Type: research

New therapy, new challenges: The effects of long-term continuous flow left ventricular assist device on inflammation
Surgically implanted continuous flow left ventricular assist devices (CF-LVADs) are currently used in patients with end-stage heart failure (HF). However, CF-LVAD therapy introduces a new set of complications and adverse events in these patients. Major adverse events with the CF-LVAD include right heart failure, vascular dysfunction, stroke, hepatic failure, and multi-organ failure, complications that may have inflammation as a common etiology. Our aim was to review the current evidence showing a relationship between these adverse events and elevated levels of inflammatory biomarkers in CF-LVAD recipients.
Source: International Journal of Cardiology - April 18, 2016 Category: Cardiology Authors: Liza Grosman-Rimon, Fillo Billia, Avi Fuks, Ira Jacobs, Michael McDonald, David Z. Cherney, Vivek Rao Tags: Review Source Type: research

Hypothermia is an independent predictor of short and intermediate term mortality in acute systolic heart failure: Insights from the ESCAPE trial
Admission hypothermia is associated with increased mortality in patients hospitalized with sepsis, trauma or stroke. We hypothesized that low body temperature patients with acute systolic heart failure (HF) would be associated with worse survival.
Source: International Journal of Cardiology - June 24, 2016 Category: Cardiology Authors: Hesham R. Omar, Maya Guglin Source Type: research

The C of CHADS: Historical Perspective and Clinical Applications for Anticoagulation in patients with Non Valvular Atrial Fibrillation and Congestive Heart Failure
The risk stratification of patients with coexisting non valvular atrial fibrillation and congestive heart failure, is often a clinical challenge, as the definitions of congestive heart failure in the popular CHADS2 and CHA2DS2VASc scoring systems, and amongst major clinical trials on Warfarin and Novel Oral Anticoagulants (NOAC) have heterogeneity. Available evidence reveals that any heart failure and/or left ventricular systolic dysfunction is associated with higher rates of stroke/systemic embolism and bleeding in patients with non valvular atrial fibrillation compared to patients without heart failure and normal left ventricular function.
Source: International Journal of Cardiology - September 16, 2016 Category: Cardiology Authors: Y Chugh, RT Faillace Tags: Editorial Source Type: research

30-year nationwide trends in incidence of atrial fibrillation in Denmark and associated 5-year risk of heart failure, stroke, and death
Long-term nationwide trends in atrial fibrillation (AF) incidence and 5-year outcomes are rare.
Source: International Journal of Cardiology - September 20, 2016 Category: Cardiology Authors: Morten Schmidt, Sinna Pilgaard Ulrichsen, Lars Pedersen, Hans Erik B øtker, Jens Cosedis Nielsen, Henrik Toft Sørensen Source Type: research

Epigallocatechin-3-gallate modulates arrhythmogenic activity and calcium homeostasis of left atrium
Atrial fibrillation (AF) is the commonest sustained arrhythmia, and increases the risk of stroke, heart failure, and mortality. Calcium (Ca2+) overload and oxidative stress are thought to participate in the pathogenesis of AF. Epigallocatechin-3-gallate (EGCG) has an antioxidative effect and been shown to be beneficial in promoting cardiovascular health. However, it is not clear if EGCG directly modulates the electrophysiological characteristics and Ca2+ homeostasis of the left atrium (LA).
Source: International Journal of Cardiology - January 13, 2017 Category: Cardiology Authors: Jun-Hei Chang, Shih-Lin Chang, Po-Da Hong, Ping-Nan Chen, Chih-Hsueng Hsu, Yen-Yu Lu, Yao-Chang Chen Source Type: research

Reply to letter to the editor: Elevated fibroblast growth factor-23 and risk for cardiovascular disease or mortality in the general population
We thank Krupp et al. for their insightful and well-thought comments on our article. We agree with them that there were some methodological flaws in our article. Studies on the association of elevated fibroblast growth factor-23 (FGF-23) levels with cardiovascular events and mortality from the general population were relatively sparse and produced less consistent results. However, considering the facts that associations of elevated FGF-23 levels with risk of cardiovascular disease, heart failure, stroke, and cardiovascular or all-caused mortality were still statically significant (Fig.
Source: International Journal of Cardiology - March 23, 2017 Category: Cardiology Authors: Menglin Jiang, Dandan Gong, Yu Fan Tags: Letter to the Editor Source Type: research

Impact of atrial arrhythmias on outcome in adults with congenital heart disease
Adults with congenital heart disease (ACHD) are affected by atrial arrhythmias (AA). To elucidate the impact of AA on prognosis, we aimed to determine the impact of AA on death, heart failure and stroke in ACHD patients in a prospective nationwide clinical registry.
Source: International Journal of Cardiology - September 22, 2017 Category: Cardiology Authors: H. Yang, J.M. Kuijpers, J.R. de Groot, T.C. Konings, A. van Dijk, G.Tj. Sieswerda, M.C. Post, B.J.M. Mulder, B.J. Bouma Tags: Short communication Source Type: research

Should small-to-moderate alcohol consumption be recommended for healthy middle-aged women?
Sex-specific differences may exist in the association of alcohol consumption and atrial fibrillation. The article by Gallagher et al. [1] demonstrated that significant associations between moderate alcohol consumption and increased risk of atrial fibrillation among men but not among women. Low alcohol consumption is not associated with an increased risk of atrial fibrillation in both genders. Light to moderate alcohol consumption has been consistently associated with reduced risks of coronary heart disease, stroke, and congestive heart failure.
Source: International Journal of Cardiology - November 30, 2017 Category: Cardiology Authors: Yang Yang, Die Hu, Daoquan Peng Tags: Letter to the Editor Source Type: research

The impact of migration on cardiovascular diseases
Cardiovascular disease (CVD) is now the leading contributor to disability-adjusted life years lost worldwide [1]. Within CVD, ischaemic heart disease and stroke rank first and second [1], with hypertensive heart disease and heart failure, rheumatic heart disease (RHD), cardiomyopathy and atrial fibrillation also contributing substantially [2]. There is clear international commitment to address this issue. The WHO 25 ×25 Global Action Plan [3], and the Sustainable Development Goals [4] set ambitious targets to reduce premature mortality from CVD.
Source: International Journal of Cardiology - January 29, 2018 Category: Cardiology Authors: Anna Odone, Charlotte McKee, Martin McKee Tags: Editorial Source Type: research

Resting heart rate in late adolescence and long term risk of cardiovascular disease in Swedish men
To investigate the association of resting heart rate (RHR) measured in late adolescence with the long term risk of myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), atrial fibrillation (AF), cardiovascular- and all-cause death.
Source: International Journal of Cardiology - March 23, 2018 Category: Cardiology Authors: Martin Lindgren, Josefina Robertson, Martin Adiels, Maria Schaufelberger, Maria Åberg, Kjell Torén, Margda Waern, N. David Åberg, Annika Rosengren Source Type: research

Search of multiple markers of organ damage for better cardiovascular risk stratification in hypertension: Role of “SHATS” syndrome in the clinical practice
Essential hypertension is a chronic, asymptomatic disease characterized by sustained and persistent rise in systolic/diastolic blood pressure (BP) levels and increased risk of developing major cardiovascular (CV) complications, including stroke, myocardial infarction, renal disease, congestive heart failure and CV death. Risk of hypertension-related CV complications can be estimated by comprehensive evaluation of individual global CV risk profile, which includes search for CV risk factors and comorbidities, as well as assessment of markers of organ damage (OD).
Source: International Journal of Cardiology - May 11, 2018 Category: Cardiology Authors: Giuliano Tocci, Vivianne Presta, Ilaria Figliuzzi, Massimo Volpe Tags: Editorial Source Type: research

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