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Sitagliptin and cardiovascular outcomes in diabetic patients with chronic kidney disease after acute myocardial infarction
Chen et al. evaluated the cardiovascular safety and efficacy of sitagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, in 1,025 type 2 diabetic patients with chronic kidney disease (CKD) after acute myocardial infarction (AMI) [1]. The authors set the primary outcomes as myocardial infarction, ischemic stroke or cardiovascular death, and they conducted a one-year follow-up with use of Cox proportional hazard models. Although, the use of sitagliptin was not associated with an increased risk of cardiovascular death, ischemic stroke or hospitalization for heart failure, hazard ratios (95% confidence intervals) of sitaglipti...
Source: International Journal of Cardiology - September 14, 2015 Category: Cardiology Authors: Tomoyuki Kawada Tags: Correspondence Source Type: research

Atrial fibrillation and heart failure: Factors influencing the choice of oral anticoagulant
Atrial fibrillation (AF) and heart failure (HF) frequently coexist. AF is identified in approximately one third of patients with HF and is linked to increased morbidity and mortality than from either condition alone. AF is relatively more common in HF with preserved ejection fraction (HFpEF) than with reduced ejection fraction (HFrEF). Nevertheless, the risk of stroke and systemic embolism (SSE) is significantly increased with both HF types and the absolute risk is heavily influenced by the presence and severity of associated additional stroke risk factors.
Source: International Journal of Cardiology - September 29, 2016 Category: Cardiology Authors: Louise A E Brown, Christopher J Boos Tags: Review Source Type: research

Glycogen synthase kinase 3 β helps heart to pump better in obese patients
Obesity is a growing problem worldwide and is associated with a wide range of comorbidities such as type-2 diabetes (T2D), rheumatoid arthritis, cognitive impairment and dementia, hypertension, stroke and heart failure [1]. The global obesity pandemic affects all age groups. A recent study, based on body mass index (BMI) in over 68 million subjects from 195 countries, suggests that prevalence of metabolic diseases was increased in high BMI subjects globally in the past 20  years [2]. The increased BMI has been shown to be pathogenically related to several diseases including cardiovascular and stroke-related diseases [3].
Source: International Journal of Cardiology - March 23, 2018 Category: Cardiology Authors: Suresh Kumar Verma Source Type: research

One for all and all for one? The dilemma of optimal management of atrial fibrillation with cardiac co-morbidities
Patients with non-valvular atrial fibrillation (AF) and concomitant heart failure or coronary artery disease (CAD) are at particularly high risk of thromboembolic complications, requiring careful stroke prevention management. The development of the direct oral anticoagulants has undoubtedly improved secondary prevention of stroke arising from venous sources, while antiplatelet therapy is an essential mainstay of secondary prevention in patients with CAD. The combination, however, is associated with an increased risk of major bleeds, so the decision whether to continue with antiplatelet treatment on top of life-long anticoa...
Source: International Journal of Cardiology - October 6, 2019 Category: Cardiology Authors: Anke C. Fender, Dobromir Dobrev Source Type: research

Assessment of atrial function by echocardiography: Can this be used to assess the arrhythmogenic atrial substrate?
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia. It is associated with a high risk for thromboembolic stroke, heart failure, decreased quality of life and cognitive impairment, all increasing mortality. After confirmation of AF, comprehensive assessment of i) stroke risk, ii) symptom severity, iii) severity of AF-burden and iv) atrial substrate severity is recommended in accordance with the 4S-AF scheme proposed by the current European AF-guidelines to provide optimal treatment for the individual patient [1].
Source: International Journal of Cardiology - June 1, 2022 Category: Cardiology Authors: Florian Bruns, Dobromir Dobrev Tags: Editorial Source Type: research

Carotid plaque is associated with increased cardiac mortality in patients with coronary artery disease
Abstract: Background: It is still controversial whether carotid plaque is associated with cardiovascular events in patients with coronary artery disease (CAD). The aim of the present study is to evaluate the impact of carotid plaque on long term clinical outcomes especially in patients with CAD.Methods: The study population consisted of 1390 consecutive patients with angiographically proven CAD. All subjects underwent carotid scanning 1day before or after coronary angiogram and were followed up for major adverse cardiovascular events (MACE; death, myocardial infarction, stroke, revascularization, restenosis and hospitaliza...
Source: International Journal of Cardiology - December 22, 2011 Category: Cardiology Authors: Hyun Woong Park, Wan Ho Kim, Ki-Hong Kim, Dong Ju Yang, Ji Hye Kim, In Girl Song, Taek-Geun Kwon, Jang-Ho Bae Tags: Original Articles Source Type: research

Early and mid-term cardiovascular outcomes following TAVI: Impact of pre-procedural transvalvular gradient
Abstract: Objective: To assess the relation of aortic transvalvular gradient with outcomes following transcatheter aortic valve implantation (TAVI).Background: Relatively little is known about the predictors of adverse outcomes in patients with severe aortic stenosis following TAVI.Methods: We studied 126 consecutive patients (mean age 83.2±6.3years; 59% women) who underwent TAVI (23% transapical; 77% transfemoral) at our institution. All patients were followed for the incidence of major adverse cardiovascular events (MACE), including myocardial infarction, heart failure, stroke, and cardiovascular death.Results: The acut...
Source: International Journal of Cardiology - March 29, 2012 Category: Cardiology Authors: Nicolas Amabile, Ramzi Ramadan, Said Ghostine, Susan Cheng, Alexandre Azmoun, François Raoux, Ngoc-Tram To, Yacine Haddouche, Xavier Troussier, Remi Nottin, Christophe Caussin Tags: Original Articles Source Type: research

The prognostic impact of in-hospital worsening of renal function in patients with acute coronary syndrome
Abstract: Background: Renal impairment is strongly linked to adverse cardiovascular (CV) events. Baseline renal dysfunction is a strong predictor of CV mortality and morbidity in patients admitted with acute coronary syndrome (ACS). However, the prognostic importance of worsening renal function (WRF) in these patients is not well characterized.Methods: ACS patients enrolled in the SPACE (Saudi Project for Assessment of Coronary Events) registry who had baseline and pre-discharge serum creatinine data available were eligible for this study. WRF was defined as a 25% reduction from admission estimated glomerular filtration ra...
Source: International Journal of Cardiology - February 20, 2012 Category: Cardiology Authors: Hussam F. AlFaleh, Abdulkareem O. Alsuwaida, Anhar Ullah, Ahmad Hersi, Khalid F. AlHabib, Khalid AlNemer, Shukri AlSaif, Amir Taraben, Tarek Kashour, Mohammed A. Balghith, Waqar H. Ahmed Tags: Original Articles Source Type: research

Atrial fibrillation: Profile and burden of an evolving epidemic in the 21st century
Abstract: Background: Atrial fibrillation (AF) represents an increasing public health challenge with profound social and economic implications.Methods: A comprehensive synthesis and review of the AF literature was performed. Overall, key findings from 182 studies were used to describe the indicative scope and impact of AF from an individual to population perspective.Results: There are many pathways to AF including advancing age, cardiovascular disease and increased levels of obesity/metabolic disorders. The reported population prevalence of AF ranges from 2.3%–3.4% and historical trends reflect increased AF incidence. Es...
Source: International Journal of Cardiology - February 4, 2013 Category: Cardiology Authors: Jocasta Ball, Melinda J. Carrington, John J.V. McMurray, Simon Stewart Tags: Reviews Source Type: research

Aldosterone, atherosclerosis and vascular events in patients with stable coronary artery disease
Conclusions: In patients with stable coronary artery disease, plasma aldosterone is independently associated with the risk of major vascular events and vascular mortality and with atherosclerotic burden.
Source: International Journal of Cardiology - June 25, 2012 Category: Cardiology Authors: Marieke A. Hillaert, Eef G. Lentjes, Hans Kemperman, Yolanda van der Graaf, Hendrik M. Nathoe, Farzin Beygui, Gilles Montalescot, Pieter A. Doevendans, Annemarie M. Wassink, Eric van Belle, on behalf of the SMART Study Group Tags: Original Articles Source Type: research

Sleep disordered breathing is an independent risk factor for left atrial enlargement in patients with congestive heart failure
Left atrial enlargement (LAE) is an independent predictor of stroke and death . In patients with congestive heart failure (CHF) LAE has a high prevalence . Several conditions such as left ventricular remodeling, mitral regurgitation and atrial fibrillation (AF) are known to cause LAE in CHF patients. Lately attention has grown on the high prevalence of sleep disordered breathing (SDB) in CHF patients . SDB is also associated with poor prognosis in patients with CHF. We investigated 234 consecutive CHF patients to evaluate whether there is a relation between LAE and SDB.
Source: International Journal of Cardiology - November 19, 2012 Category: Cardiology Authors: Wanda Mäuser, Sarah Sandrock, Thomas Demming, Laura Kotzott, Hendrik Bonnemeier Tags: Letters to the Editor Source Type: research

Arterial thrombotic events and acute coronary syndromes with cancer drugs: Are growth factors the missed link? What both cardiologist and oncologist should know about novel angiogenesis inhibitors
Abstract: We aimed to revise the increasingly accruing data about the association between anti-tyrosinkinase, “targeted” cancer drugs and the development of arterial thrombotic events or acute coronary syndromes. Further insights into the involved pathophysiologic mechanisms, and into the clinical implications are overviewed.Antiangiogenesis has become a mainstream of cancer therapy, leading to development of a specific class of drugs. Besides, a “wider” angiogenesis network made up of several growth factors, can be recognized as target of a higher number of compounds. Their widespread use has been progressively fa...
Source: International Journal of Cardiology - February 14, 2013 Category: Cardiology Authors: Elena Conti, Adriana Romiti, Maria Beatrice Musumeci, Jasmine Passerini, Luigi Zezza, Vittoria Mastromarino, Chiara D'Antonio, Paolo Marchetti, Francesco Paneni, Camillo Autore, Massimo Volpe Tags: Reviews Source Type: research

Matched dose interval and continuous exercise training induce similar cardiorespiratory and metabolic adaptations in patients with heart failure
Conclusions: ACT and AIT both induce significant improvement in aerobic capacity in patients with postinfarction CHF, without significant differences between the two training modes, provided that patients are trained at the same, individually tailored, dose of exercise. The TRIMPi method might represent a step forward in the individualization of an aerobic training tailored to the patient's clinical and functional status within cardiac rehabilitation programs.
Source: International Journal of Cardiology - July 6, 2012 Category: Cardiology Authors: Ferdinando Iellamo, Vincenzo Manzi, Giuseppe Caminiti, Cristiana Vitale, Carlo Castagna, Michele Massaro, Alessio Franchini, Giuseppe Rosano, Maurizio Volterrani Tags: Original Articles Source Type: research

Job insecurity and prognosis after myocardial infarction: The SHEEP Study
Conclusions: Our results suggest that job insecurity is an adverse prognostic factor in patients with a first AMI. Future studies are needed to confirm this finding and to determine the mechanisms underlying the observed relationship.
Source: International Journal of Cardiology - August 13, 2012 Category: Cardiology Authors: Krisztina D. László, Karin Engström, Johan Hallqvist, Anders Ahlbom, Imre Janszky Tags: Original Articles Source Type: research

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