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Geographic variations in prevalent cardiovascular disease subtypes: UK Understanding Society cohort, 2009–2010
Regional variations of cardiovascular disease (CVD) subtypes have been investigated over the last decades. Mostly, researchers focused on incidence and mortality. However, knowing the regional variations in prevalent CVD could further help medical professionals and policy makers prepare medical and social resources such as ambulance response, diagnostic acumen, and so on to be efficiently (re)allocated in the next years since rehabilitation facility will also play an important role in helping patients and family at both regional and national levels. Therefore, we aimed to provide recent evidence on regional variance in pre...
Source: International Journal of Cardiology - December 19, 2013 Category: Cardiology Authors: Ivy Shiue, Krasimira Hristova Tags: Online Letters to the Editor Source Type: research

Leukoaraiosis and ambulatory blood pressure load in a healthy elderly cohort study: The PROOF study
Abstract: Background: Old age and hypertension are consistently reported to be the main risk factors of leukoaraiosis. The association between white matter lesions (WMLs) and other cardiovascular risk factors (CVRF) remains controversial. We evaluated the association between CVRF and WMLs in a cohort study and determined the blood pressure variables that could predict WML severity.Methods: 830 subjects (65+/−1years of age, 60% women) from the PROOF study, with a reliable ABPM and brain MRI, were included. The exclusion criteria included prior myocardial infarction, stroke, heart failure, atrial fibrillation, type 1 diabe...
Source: International Journal of Cardiology - February 4, 2014 Category: Cardiology Authors: John Avet, Vincent Pichot, Jean-Claude Barthélémy, Bernard Laurent, Arnauld Garcin, Frédéric Roche, Sébastien Celle Tags: Original Articles Source Type: research

Non-standard dose dronedarone in treating atrial fibrillation patients
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia requiring medical care . Dronedarone is derived from amiodarone, but has different electrophysiological effects . Dronedarone has been approved to treat paroxysmal or persistent AF, which is associated with a reduction of AF-related hospitalization, stroke or mortality . However, dronedarone should be avoided in patients with decompensated heart failure or permanent AF due to an increased mortality .
Source: International Journal of Cardiology - January 23, 2014 Category: Cardiology Authors: Jen-Hung Huang, Yung-Kuo Lin, Ming-Hsiung Hsieh, Shih-Ann Chen, Yi-Jen Chen Tags: Online Letters to the Editor Source Type: research

The predictive value of CHADS2 risk score in post myocardial infarction arrhythmias — A Cardiac Arrhythmias and RIsk Stratification after Myocardial infArction (CARISMA) substudy
Abstract: Background: Previous studies have shown substantially increased risk of cardiac arrhythmias and sudden cardiac death in post-myocardial infarction (MI) patients. However it remains difficult to identify the patients who are at highest risk of arrhythmias in the post-MI setting. The purpose of this study was to investigate if CHADS2 score (congestive heart failure, hypertension, age ≥75years, diabetes and previous stroke/TCI [doubled]) can be used as a risk tool for predicting cardiac arrhythmias after MI.Methods: The study included 297 post-MI patients from the CARISMA study with left ventricular ejection fract...
Source: International Journal of Cardiology - April 7, 2014 Category: Cardiology Authors: Anne Christine Ruwald, Uffe Gang, Poul Erik Bloch Thomsen, Rikke Mørch Jørgensen, Martin H. Ruwald, Heikki V. Huikuri, Christian Jons Tags: Original Articles Source Type: research

Group III/IV muscle afferents impair limb blood in patients with chronic heart failure
Abstract: Objective: To better understand the hemodynamic and autonomic reflex abnormalities in heart-failure patients (HF), we investigated the influence of group III/IV muscle afferents on their cardiovascular response to rhythmic exercise.Methods: Nine HF-patients (NYHA class-II, mean left ventricular ejection-fraction: 27±3%) performed single leg knee-extensor exercise (25/50/80% peak-workload) under control conditions and with lumbar intrathecal fentanyl impairing μ-opioid receptor-sensitive muscle afferents.Results: Cardiac-output (Q) and femoral blood-flow (QL) were determined, and arterial/venous blood samples co...
Source: International Journal of Cardiology - May 5, 2014 Category: Cardiology Authors: Markus Amann, Massimo Venturelli, Stephen J. Ives, David E. Morgan, Benjamin Gmelch, Melissa A.H. Witman, H. Jonathan Groot, D. Walter Wray, Josef Stehlik, Russell S. Richardson Tags: Original Articles Source Type: research

Left ventricular hypertrabeculation/noncompaction in an Eritrean war invalid with neuromuscular disease
Left ventricular hypertrabeculation/noncompaction (LVHT) is categorized as an unclassified cardiomyopathy and is characterized by a two-layered left ventricular myocardium distal to the papillary muscles with a thicker noncompacted inner (endocardial) layer and a compacted thinner outer (pericardial) layer . LVHT is complicated by ventricular arrhythmias, stroke/embolism, or heart failure, which is why these patients require close cardiologic surveillance . In more than half of the patients LVHT is associated with a neuromuscular disorder (NMD) or a chromosomal aberration . LVHT has been occasionally reported in African pa...
Source: International Journal of Cardiology - April 28, 2014 Category: Cardiology Authors: Josef Finsterer, Claudia Stöllberger, Maria Motamen Tags: Online Letters to the Editor Source Type: research

CNS disease triggering Takotsubo stress cardiomyopathy
There are a number of hereditary and non-hereditary central nervous system (CNS) disorders, which directly or indirectly affect the heart (brain-heart disorders). The most well-known of these CNS disorders are epilepsy, stroke, infectious or immunological encephalitis/meningitis, migraine, and traumatic brain injury. In addition, a number of hereditary and non-hereditary neurodegenerative disorders may impair cardiac functions. Affection of the heart may manifest not only as arrhythmias, myocardial infarction, autonomic impairment, systolic dysfunction/heart failure, arterial hypertension, or pulmonary hypertension, but al...
Source: International Journal of Cardiology - August 26, 2014 Category: Cardiology Authors: Josef Finsterer, Karim Wahbi Source Type: research

Ischemic stroke in left ventricular noncompaction and celiac disease
Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality characterized by a hypertrabeculated left ventricular wall with a sponge-like appearance and a two-layered structure with an outer, subepicardially located compacted zone and an inner, subendocardially located noncompacted zone. Cardiac manifestations of LVHT comprise heart failure, thromboembolism and arrhythmias. LVHT is frequently associated with extracardiac diseases and neuromuscular disorders [1,2]. LVHT associated with digestive disorders, so far, has been only reported in a boy with glycogen storage disease type Ib [3].
Source: International Journal of Cardiology - July 12, 2014 Category: Cardiology Authors: Claudia Stöllberger, Josef Finsterer Tags: Letter to the Editor Source Type: research

Relationship between macular and retinal disease with prevalent atrial fibrillation – an analysis of the Australian Heart Eye Study
Atrial fibrillation (AF) is the most frequent cardiac arrhythmia, which significantly and independently predicts morbidity and mortality. AF increases overall mortality risk by 40-90%, and may be associated with underlying cardiovascular disorders including stroke and heart failure [1]. Ocular diseases including diabetic retinopathy, age-related macular degeneration (AMD) and retinal vessel calibre changes are also significant predictors of cardiovascular disease and blood pressure [2]. However, their relationship with cardiac arrhythmias such as atrial fibrillation have been relatively unexplored.
Source: International Journal of Cardiology - October 22, 2014 Category: Cardiology Authors: Kevin Phan, Paul Mitchell, Gerald Liew, Sarah B. Wang, Adam J. Plant, Aravinda Thiagalingam, George Burlutsky, Bamini Gopinath Tags: Letter to the editor Source Type: research

Patterns of cardiovascular drugs prescribed for an elderly Swedish population
Cardiovascular diseases (CVDs), such as coronary heart disease, atrial fibrillation, heart failure and stroke, are increasingly common as people age. Therefore, cardiovascular drugs are the most frequently prescribed medications for preventive and therapeutic purposes among older adults [1]. However, several factors make cardiovascular drug treatment in elderly people complicated. Age-related pathophysiological changes in the cardiovascular system, liver and kidney can affect the pharmacokinetics and pharmacodynamics of commonly used drugs, which makes older persons more vulnerable to adverse drug events [2].
Source: International Journal of Cardiology - October 7, 2014 Category: Cardiology Authors: Mozhu Ding, Rui Wang, Kristina Johnell, Chengxuan Qiu Tags: Letter to the Editor Source Type: research

Resveratrol attenuated homocysteine-induced apoptosis of neonatal ventricular myocytes
Elevated homocysteine level in the plasma is a new independent important risk factor of ischemic heart diseases, stroke, dementia, Alzheimer's disease, renal failure, osteoporotic fracture, etc. In particularly, increasing evidence has revealed a strong association of hyperhyomocystemia with cardiovascular diseases including heart failure, atria fibrillation and venous thromboembolism, so that serum homocysteine level has been considered as a diagnostic marker of myocardial infraction and an important predictor of mortality for patients with coronary artery diseases (CAD) [1].
Source: International Journal of Cardiology - September 24, 2014 Category: Cardiology Authors: Yu Liu, Qiujia Shen, Qiaojing Liu, Zhina Hu, Xiaofeng Jiang Tags: Letters to the Editor Source Type: research

Should Device Replacement Be the First Choice Strategy in Continuous-Flow Left Ventricle Assist Device Thrombosis? Analysis of 9 Events and Results after Endoventricular Thrombolysis
The incidence of HeartWare® (HeartWare Inc, Framingham, MA) continuous-flow left ventricle assist device (CF-LVAD) thrombosis ranges from 4.2% to 8% [1]. Several factors related to pump, patient and management can increase the propensity to pump thrombosis (PT) [2], and can result in stroke, peripheral embolism, heart failure, pump exchange, and death.
Source: International Journal of Cardiology - October 28, 2014 Category: Cardiology Authors: Giuseppe Maria Raffa, Giuseppe D’Ancona, Giuseppe Romano, Calogero Falletta, Sergio Sciacca, Chiara Todaro, Fabio Tuzzolino, Astrid Pietrosi, Andrea Amaducci, Francesco Clemenza, Cesare Scardulla, Michele Pilato Tags: Letter to the editor Source Type: research

Resveratrol attenuated homocysteine-induced apoptosis of rat ventricular myocytes
Elevated homocysteine level in the plasma is a new independent important risk factor of ischemic heart diseases, stroke, dementia, Alzheimer's disease, renal failure, osteoporotic fracture, etc. In particular, increasing evidence has revealed a strong association of hyperhyomocystemia with cardiovascular diseases including heart failure, atrial fibrillation and venous thromboembolism, so that serum homocysteine level has been considered as a diagnostic marker of myocardial infraction and an important predictor of mortality for patients with coronary artery diseases (CAD) [1].
Source: International Journal of Cardiology - September 24, 2014 Category: Cardiology Authors: Yu Liu, Qiaojing Liu, Zhina Hu, Qiujia Shen, Hongyan Liang, Xiaofeng Jiang Tags: Letter to the Editor Source Type: research

Risk of cardiovascular disease: The effects of diabetes and anti-diabetic drugs - a nested case-control study
Type 2 diabetes (DM) increases the risk of cardiovascular disease. We investigated the effects of antidiabetic drugs on the composite endpoint (CE) of ischemic heart disease, heart failure or stroke in DM patients.
Source: International Journal of Cardiology - November 13, 2014 Category: Cardiology Authors: Michael Gejl, Jakob Starup-Linde, Jan Scheel-Thomsen, Soeren Gregersen, Peter Vestergaard Source Type: research

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