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Heart failure and the development of atrial fibrillation in Hispanics, African Americans and non-Hispanic Whites
Atrial fibrillation (AF) is the most common cardiac arrhythmia [1], whose prevalence is increasing [1,2]. It represents a major public health problem and is closely related to stroke, mortality, decreased quality of life and a high health-care cost burden [3]. Heart failure (HF) is a growing epidemic and likely to impact 9 million US adults by 2030 [16]. AF and HF are closely linked [5], sharing similar risk factors with neurohormonal, cellular, extracellular and electrophysiologic changes of one predisposing the other [6 –8].
Source: International Journal of Cardiology - May 22, 2018 Category: Cardiology Authors: Eric Shulman, Tina Shah, Alon Y. Mazori, Jay J. Chudow, Faraj Kargoli, Dmitriy Nevelev, Jorge Romero, Luigi Di Biase, John Fisher, Jay Gross, Kevin J. Ferrick, Andrew Krumerman Source Type: research

Vagal impact of cryoballoon ablation during pulmonary vein isolation
Atrial fibrillation (AF) is the most common cardiac arrhythmia, resulting in hemodynamic abnormalities and thromboembolic events. The prevalence of AF is around 1% in the general population, increasing with age. It results in a 5-fold increased risk of ischemic stroke, 3-fold increased risk of heart failure, and 2-fold increased risk of both dementia and mortality. Hassaiguerre et al. [1] and Chen et al. [2] firstly reported the dominant and pathologic role of pulmonary vein (PV) triggers as being responsible for the arrhythmogenesis of AF.
Source: International Journal of Cardiology - June 7, 2018 Category: Cardiology Authors: Ting-Yung Chang, Chin-Yu Lin, Shih-Ann Chen Tags: Editorials Source Type: research

Reduction of heart rate in patients with heart failure aiming to improve ventricular-arterial coupling
We appreciated the comment by Dr. Guarraccino et al. regarding our previous Review [1]. Ventricular-arterial coupling (VAC) is expression of left ventricular (LV) loading status, a determinant of stroke volume (SV). Heart rate (HR) reduction by ivabradine in a sub-analysis of the SHIFT trial has demonstrated to improve total arterial compliance, decreasing effective arterial elastance without affecting end-systolic elastance [2]. Thus, they demonstrated that ivabradine improves VAC and SV.
Source: International Journal of Cardiology - June 7, 2018 Category: Cardiology Authors: Andrea Buono, Fabrizio Oliva, Enrico Ammirati Tags: Letter to the Editor Source Type: research

Bayes syndrome: Improving risk stratification in chronic heart failure?
The progressive ageing of population is leading to a significant increase of the incidence of heart failure (HF), one of the epidemics of the 21th Century. In addition, atrial fibrillation (AF) is the most common arrhythmia in elderly patients, and is associated with a higher incidence of stroke and mortality. A significant association between HF and AF has been consistently described, and its combination increases morbidity and mortality.
Source: International Journal of Cardiology - June 13, 2018 Category: Cardiology Authors: Albert Ariza-Sol é, Carme Guerrero, Francesc Formiga Tags: Editorial Source Type: research

Letter: Cardiovascular events after ICU discharge in patients with new-onset atrial fibrillation: A report from the FROG-ICU study
We would like to thank Dr. Guenancia for suggesting a more detailed description of the major adverse cardiovascular and cerebrovascular events (MACCE, i.e. acute heart failure (AHF), myocardial infarction and stroke) occurring to the 1464 ICU survivors of the FROG-ICU cohort, to better understand the observed detrimental prognostic impact of atrial fibrillation (AFib) in critically ill patients [1, 2].
Source: International Journal of Cardiology - July 20, 2018 Category: Cardiology Authors: Mattia Arrigo, Elodie Feliot, Etienne Gayat, Alexandre Mebazaa Tags: Letter to the editor Source Type: research

Cardiovascular events after ICU discharge in patients with new-onset atrial fibrillation: A report from the FROG-ICU study
We would like to thank Dr. Guenancia for suggesting a more detailed description of the major adverse cardiovascular and cerebrovascular events (MACCE, i.e. acute heart failure (AHF), myocardial infarction and stroke) occurring to the 1464 ICU survivors of the FROG-ICU cohort, to better understand the observed detrimental prognostic impact of atrial fibrillation (AFib) in critically ill patients [1, 2].
Source: International Journal of Cardiology - July 20, 2018 Category: Cardiology Authors: Mattia Arrigo, Elodie Feliot, Etienne Gayat, Alexandre Mebazaa Tags: Letter to the editor Source Type: research

Copeptin as a prognostic biomarker in acute myocardial infarction
Copeptin - the C-terminal section of vasopressin precursor - is a novel biomarker, that has been shown to be a useful prognostic factor in heart failure, ischemic stroke and in acute myocardial infarction (MI) but with restricted population and follow-up in ST-segment elevation MI (STEMI) setting. We evaluated in this study the hypothesis that copeptin measured on admission is an independent predictor of one-year all-cause mortality after a STEMI.
Source: International Journal of Cardiology - September 6, 2018 Category: Cardiology Authors: Benoit Lattuca, Vuthy Sy, Lee Nguyen, Maguy Bernard, Michel Zeitouni, Pavel Overtchouk, Yan Yan, Nadjib Hammoudi, Alexandre Ceccaldi, Jean-Philippe Collet, Mathieu Kerneis, Abdourahmane Diallo, Gilles Montalescot, Johanne Silvain Source Type: research

New-onset atrial fibrillation in ICU: A FROG in the throat
We read with interest the recent paper by M. Arrigo et al. [1]. The authors provide for the first time prospective multicentre results on long-term prognosis of new-onset atrial fibrillation (NOAF) in critical illness patients, thus highlighting the need for a better understanding of the pathophysiological mechanisms involved. Indeed, although a major focus on stroke risk has been brought forward recently, heart failure events are one of the major determinants of the poor prognosis carried by AF patients in the general population as well as in post-ICU one's.
Source: International Journal of Cardiology - September 13, 2018 Category: Cardiology Authors: Charles Guenancia, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Pierre Quenot Tags: Letter to the Editor Source Type: research

Cheyne-Stokes respiration in heart failure: Only provocative pathophysiology will provide new insights!
Cheyne-Stokes respiration (CSR) - a type of periodic breathing characterised by periods of hyperventilation (crescendo-decrescendo pattern) that alternate with central apneas - is highly prevalent in patients with systolic heart failure (HF) [1 –3]. CSR has been hypothesised to further increase sympathetic drive and stroke volume, thus exerting detrimental effects if left untreated [4]. At least, this is what most people thought prior to publication of the SERVE-HF trial in 2015 [5]. This trial enrolled more than 1300 patients with systo lic HF and central sleep apnea who were randomly assigned to adaptive servo-ventilat...
Source: International Journal of Cardiology - May 2, 2019 Category: Cardiology Authors: Jens Spiesshoefer Tags: Editorial Source Type: research

The hospitalizations in hypertrophic cardiomyopathy: “the dark side of the moon”.
Hypertrophic cardiomyopathy (HCM) is a myocardial disease characterized by left ventricular hypertrophy not solely explainable by abnormal loading condition [1,2]. Patients with HCM show a different clinical course, ranging from an asymptomatic status, with no adverse events and normal or extended longevity, to a symptomatic condition in which several disease complications can occur [3]. Among HCM patients which experience disease progression, 3 different pathways have been identified: refractory heart failure (HF), requiring surgical myectomy/alcohol ablation (obstructive HCM, OHCM) or heart transplant (non-obstructive HC...
Source: International Journal of Cardiology - August 14, 2020 Category: Cardiology Authors: Emanuele Monda, Giuseppe Limongelli Tags: Editorial Source Type: research

The hospitalizations in hypertrophic cardiomyopathy: “The dark side of the moon”
Hypertrophic cardiomyopathy (HCM) is a myocardial disease characterized by left ventricular hypertrophy not solely explainable by abnormal loading condition [1,2]. Patients with HCM show a different clinical course, ranging from an asymptomatic status, with no adverse events and normal or extended longevity, to a symptomatic condition in which several disease complications can occur [3]. Among HCM patients which experience disease progression, 3 different pathways have been identified: refractory heart failure (HF), requiring surgical myectomy/alcohol ablation (obstructive HCM, OHCM) or heart transplant (non-obstructive HC...
Source: International Journal of Cardiology - August 14, 2020 Category: Cardiology Authors: Emanuele Monda, Giuseppe Limongelli Tags: Editorial Source Type: research

Determinants of outcome in patients with heart failure with reduced ejection fraction & secondary mitral regurgitation
The outcome of secondary mitral regurgitation (MR) in patients with heart failure is poor. Survival is related to the severity of MR. We sought to investigate the effect of left ventricular contractility, the ratio of left ventricular end-diastolic volume (LVEDV) to effective orifice area (EROA) and the ratio of regurgitant volume (RVol) to stroke volume (SV) on cardiovascular survival.
Source: International Journal of Cardiology - September 6, 2020 Category: Cardiology Authors: Athina Chasapi, Nikos Karogiannis, Spyridon Zidros, Kush Patel, Guy Lloyd, Sanjeev Bhattacharyya Source Type: research

Impact of History of Depression on 1-Year Outcomes in Patients with Chronic Coronary Syndromes: An Analysis of a Contemporary, Prospective, Nationwide Registry
Background. Depression is common in patients with acute cardiovascular conditions and it is associated with adverse clinical events.Methods. Using the data from a nationwide, prospective registry on patients with chronic coronary syndromes (CCS), we assessed the impact of depression on major adverse cardiovascular events (MACE), a composite of all-cause death and hospitalization for myocardial infarction, revascularization, heart failure or stroke, and quality of life (QoL) at 1-year follow-up.Results.
Source: International Journal of Cardiology - January 7, 2021 Category: Cardiology Authors: Luca, Pier Luigi Temporelli, Antonio Francesco Amico, Lucio Gonzini, Massimo Uguccioni, Elisabetta Varani, Natale Daniele Brunetti, Furio Colivicchi, Domenico Gabrielli, Michele Massimo Gulizia Source Type: research

Diastolic dysfunction in women with ischemia and non-obstructive coronary arteries (INOCA) – Could non-invasive imaging reveal the missing piece of puzzle?
A large proportion of patients with chronic coronary syndromes will not have obstructive coronary artery disease (CAD) on invasive coronary angiography, more often women than men [1]. Ischemia with non-obstructive coronary arteries (INOCA), once considered a benign condition, is now recognized to be associated with increased risk of adverse events, including heart failure (HF), myocardial infarction, stroke and cardiovascular death as well as increased number of hospitalizations [2 –5]. Among INOCA patients, those with evidence of both coronary microvascular and diastolic dysfunction seem to bear the highest risk of adve...
Source: International Journal of Cardiology - April 16, 2021 Category: Cardiology Authors: Anca Florian Tags: Editorial Source Type: research

Proteomic profiles of patients with atrial fibrillation provide candidate biomarkers for diagnosis
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide with an increasing risk of heart failure, stroke, and thromboembolic events. Currently distinct pathophysiological mechanisms during AF development and valuable biomarkers for AF management remain unknown.
Source: International Journal of Cardiology - September 27, 2021 Category: Cardiology Authors: WeiYi Zhong, Hui Yang, YuLin Wang, Ye Yang, ChangFa Guo, ChunSheng Wang, Qiang Ji Source Type: research

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