Cystatin C and risk of atrial fibrillation in elderly hypertensive patients without chronic kidney disease

Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, associated with increased risk of stroke, heart failure, and mortality [1]. Epidemiological evidence indicates that there is increased risk of AF in patients with chronic kidney disease (CKD) [2–4], while CKD is an independent risk factor for the development of AF [5–7]. Cystatin C (Cys-C) is a low molecular weight protein secreted by all nucleated cells at a constant rate. Cys-C can be freely filtrated through the glomerulus, and is almost completely reabsorbed and degraded in the proximal tubules [8].

Source: International Journal of Cardiology - March 23, 2016 Category: Cardiology Authors: Wenqian Wang, Ruyu Yuan, Panagiotis Korantzopoulos, Gang Xu, Xudan Cui, Guangping Li, Tong Liu Source Type: research