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Time-averaged level of fibroblast growth factor-23 and clinical events in chronic kidney disease
Conclusions Our study confirms that FGF23 is an important cardiovascular risk factor. Two measurements of FGF23 have no added value over a single value to predict the cardiovascular outcome. This study demonstrates that, under routine clinical practice, the variability of FGF23 in 2 years' time is small. Concomitantly, this study showed no benefit of consecutive FGF23 testing for estimating the risk of a clinical event in an individual patient.
Source: Nephrology Dialysis Transplantation - January 10, 2014 Category: Urology & Nephrology Authors: Bouma-de Krijger, A., Bots, M. L., Vervloet, M. G., Blankestijn, P. J., ter Wee, P. W., van Zuilen, A. D., Wetzels, J. F. Tags: Chronic Kidney Disease Source Type: research

Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial
Conclusions Among maintenance dialysis patients with hypertension and left ventricular hypertrophy, atenolol-based antihypertensive therapy may be superior to lisinopril-based therapy in preventing cardiovascular morbidity and all-cause hospitalizations. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases; ClinicalTrials.gov number: NCT00582114)
Source: Nephrology Dialysis Transplantation - February 28, 2014 Category: Urology & Nephrology Authors: Agarwal, R., Sinha, A. D., Pappas, M. K., Abraham, T. N., Tegegne, G. G. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Bisphosphonates and Mortality in Women with CKD and the Presence or Absence of Cardiovascular Disease.
CONCLUSION: In this study of women with CKD, the association between bisphosphonate treatment and mortality risk was inconclusive across a series of analyses designed to account for various types of selection and indication bias. PMID: 24578337 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 27, 2014 Category: Urology & Nephrology Authors: Perkins RM, Kirchner HL, Matsushita K, Bucaloiu ID, Norfolk E, Hartle JE Tags: Clin J Am Soc Nephrol Source Type: research

Renal "hyperfiltrators" are at elevated risk of death and chronic diseases
Conclusion: Renal "hyperfiltrators" represent individuals with autoimmune activation (involving serum creatinine, partly escaping assay), are misclassified into optimal renal function and actually are at significantly higher risk of death, HF or cardiopulmonary events. Low serum creatinine levels may represent a clue to the existence of autoimmune activation.
Source: BMC Nephrology - October 2, 2014 Category: Urology & Nephrology Authors: Servet AltayAltan OnatFatma Özpamuk-KaradenizYusuf KaradenizTu¿ba Kemalo¿lu-ÖzGünay Can Source Type: research

Vasopressin receptor antagonists for the treatment of heart failure: a systematic review and meta-analysis of randomized controlled trials
Conclusions Vasopressin receptors antagonists may reduce body weight and increase Na but do not improve all-cause mortality, cardiovascular mortality or kidney function. In addition, acceptability of long-term treatment side effects and hospitalization appears problematic.
Source: International Urology and Nephrology - October 3, 2014 Category: Urology & Nephrology Source Type: research

Renal ¿hyperfiltrators¿ are at elevated risk of death and chronic diseases
Conclusion: Renal “hyperfiltrators” represent individuals with autoimmune activation (involving serum creatinine, partly escaping assay), are misclassified into optimal renal function and actually are at significantly higher risk of death, HF or cardiopulmonary events. Low serum creatinine levels may represent a clue to the existence of autoimmune activation.
Source: BMC Nephrology - October 2, 2014 Category: Urology & Nephrology Authors: Servet AltayAltan OnatFatma Özpamuk-KaradenizYusuf KaradenizTu¿ba Kemalo¿lu-ÖzGünay Can Source Type: research

Visit-to-Visit Variability in Blood Pressure and Kidney and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Nephropathy: A Post Hoc Analysis From the RENAAL Study and the Irbesartan Diabetic Nephropathy Trial
Conclusions In diabetic individuals with nephropathy, systolic blood pressure visit-to-visit variability is associated independently with hard kidney disease outcomes.
Source: American Journal of Kidney Diseases - October 29, 2014 Category: Urology & Nephrology Source Type: research

Assessment of Achieved Clinic and Ambulatory Blood Pressure Recordings and Outcomes During Treatment in Hypertensive Patients With CKD: A Multicenter Prospective Cohort Study
Conclusions In patients with treated CKD, clinic BP above goal and ambulatory BP at goal identify a low-risk condition, whereas clinic BP at goal and ambulatory BP above goal are associated with higher cardiorenal risk, similar to that observed in patients with both clinic and ambulatory BPs above goal.
Source: American Journal of Kidney Diseases - October 29, 2014 Category: Urology & Nephrology Source Type: research

Urine Neutrophil Gelatinase-Associated Lipocalin and Risk of Cardiovascular Disease and Death in CKD: Results From the Chronic Renal Insufficiency Cohort (CRIC) Study
Conclusions Among patients with chronic kidney disease, urine levels of NGAL, a marker of renal tubular injury, were associated independently with future ischemic atherosclerotic events, but not with heart failure events or deaths.
Source: American Journal of Kidney Diseases - October 29, 2014 Category: Urology & Nephrology Source Type: research

Association Between Chronic Kidney Disease Progression and Cardiovascular Disease: Results from the CRIC Study.
Conclusions: Self-reported heart failure was an independent risk factor for the development of the endpoint of ESRD or 50% decline in GFR in a cohort of patients with chronic kidney disease. © 2014 S. Karger AG, Basel. PMID: 25401485 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - November 11, 2014 Category: Urology & Nephrology Authors: Rahman M, Xie D, Feldman HI, Go AS, He J, Kusek JW, Lash J, Miller Iii ER, Ojo A, Pan Q, Seliger SL, Steigerwalt S, Townsend RR Tags: Am J Nephrol Source Type: research

Effects of Sleepiness on Survival in Japanese Hemodialysis Patients: J-DOPPS Study
Sleep disorder and poor sleep quality are common in chronic hemodialysis (HD) patients. They have been claimed as a cause of morbidity and mortality. The relationship between the degree of sleepiness and survival has not been studied. We studied the degree of sleepiness in 1,252 adult HD patients (age ≥20 years) recruited into the Dialysis Outcomes Practice Pattern Study in Japan (J-DOPPS III), using the Japanese version of the Epworth Sleepiness Scale (JESS) questionnaire. Demographic data were presented for three subgroups: low, intermediate, and high JESS score. Cox proportional hazard regression analysis was performe...
Source: Nephron Clinical Practice - January 8, 2015 Category: Urology & Nephrology Source Type: research

Subclinical Atherosclerosis Measures for Cardiovascular Prediction in CKD
In conclusion, each measure improved cardiovascular risk prediction in subjects with CKD, with the greatest improvement observed with coronary artery calcium score.
Source: Journal of the American Society of Nephrology : JASN - January 30, 2015 Category: Urology & Nephrology Authors: Matsushita, K., Sang, Y., Ballew, S. H., Shlipak, M., Katz, R., Rosas, S. E., Peralta, C. A., Woodward, M., Kramer, H. J., Jacobs, D. R., Sarnak, M. J., Coresh, J. Tags: Clinical Epidemiology Source Type: research

Development and Validation of a Model to Predict 5-Year Risk of Death without ESRD among Older Adults with CKD.
CONCLUSIONS: A simple prediction tool using nine readily available clinical variables can assist in predicting 5-year mortality risk in elderly patients with CKD, which may be useful in counseling patients and guiding clinical decision making. PMID: 25710804 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 20, 2015 Category: Urology & Nephrology Authors: Bansal N, Katz R, De Boer IH, Peralta CA, Fried LF, Siscovick DS, Rifkin DE, Hirsch C, Cummings SR, Harris TB, Kritchevsky SB, Sarnak MJ, Shlipak MG, Ix JH Tags: Clin J Am Soc Nephrol Source Type: research

Epidemiologic insights on the role of fibroblast growth factor 23 in cardiovascular disease
Purpose of review: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Animal studies have demonstrated direct and indirect effects of FGF23 that may promote heart disease. Herein, we review the recent epidemiologic literature evaluating the relationship between FGF23 and cardiovascular disease. Recent findings: In observational prospective studies, higher FGF23 associates with a greater risk of incident cardiovascular disease including ischemic heart disease, stroke, heart failure, and atrial fibrillation. These studies establish a temporal sequence of e...
Source: Current Opinion in Nephrology and Hypertension - April 14, 2015 Category: Urology & Nephrology Tags: EPIDEMIOLOGY AND PREVENTION: Edited by Navdeep Tangri Source Type: research

Association Between Kidney Function, Rehabilitation Outcome, and Survival in Older Patients Discharged From Inpatient Rehabilitation
Conclusions eGFR category and Barthel score are independent risk markers for survival in older rehabilitation patients, but advanced CKD does not preclude successful rehabilitation.
Source: American Journal of Kidney Diseases - June 2, 2015 Category: Urology & Nephrology Source Type: research

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