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Time-averaged level of fibroblast growth factor-23 and clinical events in chronic kidney disease
Conclusions Our study confirms that FGF23 is an important cardiovascular risk factor. Two measurements of FGF23 have no added value over a single value to predict the cardiovascular outcome. This study demonstrates that, under routine clinical practice, the variability of FGF23 in 2 years' time is small. Concomitantly, this study showed no benefit of consecutive FGF23 testing for estimating the risk of a clinical event in an individual patient.
Source: Nephrology Dialysis Transplantation - January 10, 2014 Category: Urology & Nephrology Authors: Bouma-de Krijger, A., Bots, M. L., Vervloet, M. G., Blankestijn, P. J., ter Wee, P. W., van Zuilen, A. D., Wetzels, J. F. Tags: Chronic Kidney Disease Source Type: research

Efficacy of Prophylactic Intra‐Aortic Balloon Pump Therapy in Chronic Heart Failure Patients Undergoing Cardiac Surgery
This study investigated the efficacy of prophylactic intraoperative intra‐aortic balloon pump (IABP) usage in chronic heart failure patients with severely reduced left ventricular function undergoing elective cardiac surgery. Between January 2008 and December 2012, 107 patients with severely reduced left ventricular ejection fraction (LVEF <35%) received prophylactic intraoperative IABP implantation during open‐heart surgery. Surgical procedures performed were isolated coronary artery bypass grafting (CABG) in 35 patients (32.7%), aortic valve replacement in 12 (11.2%), mitral valve repair or replacement in 15 (14.0...
Source: Artificial Organs - February 1, 2014 Category: Transplant Surgery Authors: Yalin Yildirim, Simon Pecha, Mathias Kubik, Yousuf Alassar, Tobias Deuse, Samer Hakmi, Hermann Reichenspurner Tags: Thoughts and Progress Source Type: research

Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial
Conclusions Among maintenance dialysis patients with hypertension and left ventricular hypertrophy, atenolol-based antihypertensive therapy may be superior to lisinopril-based therapy in preventing cardiovascular morbidity and all-cause hospitalizations. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases; ClinicalTrials.gov number: NCT00582114)
Source: Nephrology Dialysis Transplantation - February 28, 2014 Category: Urology & Nephrology Authors: Agarwal, R., Sinha, A. D., Pappas, M. K., Abraham, T. N., Tegegne, G. G. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Bisphosphonates and Mortality in Women with CKD and the Presence or Absence of Cardiovascular Disease.
CONCLUSION: In this study of women with CKD, the association between bisphosphonate treatment and mortality risk was inconclusive across a series of analyses designed to account for various types of selection and indication bias. PMID: 24578337 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 27, 2014 Category: Urology & Nephrology Authors: Perkins RM, Kirchner HL, Matsushita K, Bucaloiu ID, Norfolk E, Hartle JE Tags: Clin J Am Soc Nephrol Source Type: research

Can the temporary use of right ventricular assist devices bridge patients with acute right ventricular failure after cardiac surgery to recovery?
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: Can the temporary use of right ventricular assist devices (RVADs) bridge patients to recovery who suffer acute right ventricular failure after cardiac surgery? More than 183 papers were found using the reported search, of which 13 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Indications for surgical intervention included coronary artery bypas...
Source: Interactive CardioVascular and Thoracic Surgery - March 17, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Lang, S. A., O'Neill, B., Waterworth, P., Bilal, H. Tags: Adult Cardiac Source Type: research

Post-approval study of a highly pulsed, low-shear-rate, continuous-flow, left ventricular assist device, EVAHEART: A Japanese multicenter study using J-MACS
Conclusions: The EVAHEART device provides safe, reliable and long-term circulatory support with improved survival in commercial settings of BTT in Japan, where the transplant waiting period is much longer. Incidences of GI bleeding, hemolysis, right ventricular failure, device thrombosis and mechanical failure were extremely rare in patients on EVAHEART devices.
Source: The Journal of Heart and Lung Transplantation - March 6, 2014 Category: Transplant Surgery Authors: Satoshi Saito, Kenji Yamazaki, Tomohiro Nishinaka, Yuki Ichihara, Minoru Ono, Syunei Kyo, Takashi Nishimura, Takeshi Nakatani, Koichi Toda, Yoshiki Sawa, Ryuji Tominaga, Tadahisa Tanoue, Yoshikatsu Saiki, Yoshiro Matsui, Takahiro Takemura, Hiroshi Niinami Tags: Featured Articles Source Type: research

Abstract 125: Clinical Outcomes Following Continuous-Flow Left Ventricular Assist Device: A Systematic Review Session Title: Poster Session I
Conclusion: The totality of data for CF LVADs show consistent improvements in survival and quality of life counterbalanced by a range of common complications. While this summary should provide a practical resource for health care provider-led discussions with patients, it highlights the critical need for high-quality patient-centered data collected with standard definitions.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: McIlvennan, C. K., Magid, K. H., Ambardekar, A. V., Thompson, J. S., Matlock, D. D., Allen, L. A. Tags: Session Title: Poster Session I Source Type: research

Genotype-Positive Status in Patients With Hypertrophic Cardiomyopathy Is Associated With Higher Rates of Heart Failure Events Original Articles
Conclusions— The presence of a pathogenic sarcomere mutation in patients with hypertrophic cardiomyopathy was associated with an increase in heart failure events, with no differences in event rates seen between myosin heavy chain and myosin-binding protein C genotype-positive patients. The presence of a disease-causing mutation seems more clinically relevant than the specific mutation itself.
Source: Circulation: Cardiovascular Genetics - August 19, 2014 Category: Cardiology Authors: Li, Q., Gruner, C., Chan, R. H., Care, M., Siminovitch, K., Williams, L., Woo, A., Rakowski, H. Tags: Other heart failure, Myocardial cardiomyopathy disease, Genetics of cardiovascular disease Original Articles Source Type: research

Chronic kidney disease in Primary Health Care: Prevalence and associated risk factors.
CONCLUSIONS: Chronic kidney disease has considerable prevalence in subjects≥60 years seen in Primary Health Care, more in women, and increasing with age. Hypertension, more than diabetes, was the main associated cardiovascular risk factor. PMID: 25212720 [PubMed - as supplied by publisher]
Source: Atencion Primaria - September 8, 2014 Category: Primary Care Authors: Salvador González B, Rodríguez Pascual M, Ruipérez Guijarro L, Ferré González A, Cunillera Puertolas O, Rodríguez Latre LM Tags: Aten Primaria Source Type: research

Clinical Outcomes After Continuous-Flow Left Ventricular Assist Device: A Systematic Review Original Articles
Conclusions— The totality of data for continuous-flow left ventricular assist devices show consistent improvements in survival and quality of life counterbalanced by a range of common complications. Although this summary should provide a practical resource for healthcare provider-led discussions with patients, it highlights the critical need for high-quality patient-centered data collected with standard definitions.
Source: Circulation: Heart Failure - November 18, 2014 Category: Cardiology Authors: McIlvennan, C. K., Magid, K. H., Ambardekar, A. V., Thompson, J. S., Matlock, D. D., Allen, L. A. Tags: Congestive, CV surgery: transplantation, ventricular assistance, cardiomyopathy Original Articles Source Type: research

Preexisting Atrial Fibrillation and Cardiac Complications After Liver Transplantation
Conclusion: Although patients with AF have a higher incidence of intraoperative cardiac events, a higher cardiovascular morbidity and a complicated postoperative course, this did not affect overall graft and patient survival. This article is protected by copyright. All rights reserved.
Source: Liver Transplantation - December 8, 2014 Category: Transplant Surgery Authors: Johannes Bargehr, Jorge F. Trejo‐Gutierrez, Tushar Patel, Barry Rosser, Jaime Aranda‐Michel, Maria L. Yataco, C. Burcin Taner Tags: Original Article Source Type: research

Racial and ethnic differences in mortality and cardiovascular events among patients with end‐stage renal disease due to lupus nephritis
Conclusion: Among patients with LN ESRD, Asians and Hispanics experienced lower mortality and CV event risks, while African Americans had higher mortality and CV event risks compared to Whites. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - January 1, 2015 Category: Rheumatology Authors: Jose A. Gómez‐Puerta, Candace H. Feldman, Graciela S. Alarcón, Hongshu Guan, Wolfgang C. Winkelmayer, Karen H. Costenbader Tags: Original Article Source Type: research

Lessons Learned from 150 Continuous-Flow Left Ventricular Assist Devices: A Single Institutional 7 Year Experience
Continuous-flow (CF) left ventricular assist devices (LVADs) have become the standard of care for patients with advanced heart failure refractory to optimal medical therapy. The goal of this study was to review our 7 year single institutional experience with CF LVADs. Mean age was 50.4 + 12.5 (17–69) years for bridge-to-transplantation (BTT) patients and 57.6 + 10.4 (31–81) years for destination therapy (DT) patients (p
Source: ASAIO Journal - May 1, 2015 Category: Medical Equipment Tags: Adult Circulatory Support Source Type: research

Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies
ConclusionsIn a large longitudinally assessed adult HCM cohort, we have demonstrated that contemporary management strategies and treatment interventions, including ICDs for SD prevention, have significantly altered the clinical course, now resulting in a low disease-related mortality rate of 0.5%/year and an opportunity for extended longevity.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - May 4, 2015 Category: Cardiology Source Type: research

Framingham score, renal dysfunction, and cardiovascular risk in liver transplant patients
Cardiovascular (CV) events represent major impediments to the long‐term survival of liver transplantation (LT) patients. The aim of this study was to assess whether the Framingham risk score (FRS) at transplantation can predict the development of post‐LT cardiovascular events (CVEs). Patients transplanted between 2006 and 2008 were included. Baseline features, CV risk factors, and CVEs occurring after LT (ischemic heart disease, stroke, heart failure, de novo arrhythmias, and peripheral arterial disease) were recorded. In total, 250 patients (69.6% men) with a median age of 56 years (range, 18‐68 years) were included...
Source: Liver Transplantation - May 26, 2015 Category: Transplant Surgery Authors: Tommaso Di Maira, Angel Rubin, Lorena Puchades, Victoria Aguilera, Carmen Vinaixa, Maria Garcia, Nicola De Maria, Erica Villa, Rafael Lopez‐Andujar, Fernando San Juan, Eva Montalva, Judith Perez, Martin Prieto, Marina Berenguer Tags: Original Article Source Type: research

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