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Condition: Heart Failure
Education: Study
Procedure: Heart Transplant

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Total 258 results found since Jan 2013.

Impact of age on outcomes following continuous-flow left ventricular assist device implantation
CONCLUSIONS This study demonstrates that LVAD therapy can be used in the older patients with acceptable mortality and morbidity, and age alone should not be used as the sole criterion for exclusion from LVAD implantation.
Source: Interactive CardioVascular and Thoracic Surgery - May 28, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Lushaj, E. B., Badami, A., Osaki, S., Murray, M., Leverson, G., Lozonschi, L., Akhter, S., Kohmoto, T. Tags: Peripheral vascular Adult Cardiac Source Type: research

Low incidence of gastrointestinal bleeding and pump thrombosis in patients receiving the INCOR LVAD system in the long-term follow-up.
CONCLUSIONS: In this cohort of high-risk, advanced HF patients, the INCOR LVAD provided effective support with improved survival. Moreover, the absence of GI bleeding and pump thrombosis demonstrates a favorable characteristic of this device. Further prospective studies are needed to confirm these data. PMID: 26541278 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - October 28, 2015 Category: Transplant Surgery Authors: Iacovoni A, Centofanti P, Attisani M, Verde A, Terzi A, Senni M, Maiani M, Baronetto A, Livi U, Frigerio M, Rinaldi M Tags: Int J Artif Organs Source Type: research

Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial
Background: Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion strategy is associated with a reduction of infection and death. A transfusion strategy using a single PRBC unit has been retrospectively investigated and showed a safe reduction of PRBC consumption and costs. We therefore designed a study to prospectively demonstrate that the tra...
Source: Trials - November 23, 2015 Category: Journals (General) Authors: Sylvain ChantepieJean-Baptiste MearLydia GuittetBenoît DervauxJean-Pierre MarolleauFabrice JardinJean-Jacques DutheilJean-Jacques ParientiJean-Pierre VilqueOumedaly Reman Source Type: research

Fully Magnetically Levitated Left Ventricular Assist System for Treating Advanced HF A Multicenter Study
ConclusionsThe results show that the fully magnetically levitated centrifugal-flow chronic LVAS is safe, with high 30-day and 6-month survival rates, a favorable adverse event profile, and improved quality of life and functional status. (HeartMate 3™ CE Mark Clinical Investigation Plan [HM3 CE Mark]; NCT02170363)
Source: Journal of the American College of Cardiology - December 7, 2015 Category: Cardiology Source Type: research

Direct epicardial assist device using artificial rubber muscle in a swine model of pediatric dilated cardiomyopathy.
CONCLUSIONS: Use of a circumferential direct epicardial assistant device resulted in improvement in hemodynamic data in a dilated cardiomyopathy model. Although there is still a need for improvements in device components, the direct cardiac assist device may be a good alternative to recent heart failure device therapies. PMID: 26659480 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - December 7, 2015 Category: Transplant Surgery Authors: Saito Y, Suzuki Y, Kondo N, Kowatari R, Daitoku K, Minakawa M, Fukuda I Tags: Int J Artif Organs Source Type: research

Pulsatile-flow mechanical circulatory support (MCS) as a bridge to transplantation or recovery. Single-centre experience with the POLCAS system in 2014.
CONCLUSIONS: The POLCAS heart assist system is an effective method of treatment as a bridge to transplantation or recovery in patients with end-stage heart failure. Early survival after the treatment remains at a satisfactory level. The main problem is the large number of complications related to the therapy. PMID: 26702278 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - January 20, 2016 Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research

Adherence to antihypertensive therapy among heart transplant recipients.
CONCLUSIONS: Creation of an active attitude of the patient in the process of treatment is a crucial and at the same time often difficult task demanding cooperation of the patient, the patient's close family and the whole therapeutic team. PMID: 26336447 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - January 20, 2016 Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research

Outcomes on Continuous Flow Left Ventricular Assist Devices: A Single Institutional 9-Year Experience
Conclusions These data indicate excellent survival for BTT and DT patients on long-term LVAD support. However, for LVAD therapy to become a plausible alternative to heart transplantation, we need to further decrease the incidence of postoperative complications.
Source: The Annals of Thoracic Surgery - May 9, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Outcomes on Continuous Flow Left Ventricular Assist Devices: A Single Institutional 9-Year Experience.
CONCLUSIONS: These data indicate excellent survival for BTT and DT patients on long-term LVAD support. However, for LVAD therapy to become a plausible alternative to heart transplantation, we need to further decrease the incidence of postoperative complications. PMID: 27173072 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 9, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Morgan JA, Go PH, Xuereb L, Kaur B, Akrawe S, Nemeh HW, Borgi J, Lanfear DE, Williams CT, Paone G Tags: Ann Thorac Surg Source Type: research

Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-Term Risk of Cardiac Death in Patients wtih Hypertrophic Cardiomyopathy
The Objective of this study is to investigate the prognostic significance of 12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients with hypertrophic cardiomyopathy (HC). 1004 consecutive patients with HC and a recorded standard ECG (64% men, mean age 50±16 years) were evaluated at 4 Italian centres. The study end-points were sudden cardiac death (SCD) or surrogates, including appropriate implanted cardiac defibrillator discharge and resuscitated cardiac arrest) and major cardiovascular events (including SCD or surrogates and death due to heart failure, cardioembolic stroke or heart transplantation).
Source: The American Journal of Cardiology - May 14, 2016 Category: Cardiology Authors: Elena Biagini, Chiara Pazzi, Iacopo Olivotto, Beatrice Musumeci, Giuseppe Limongelli, Giuseppe Boriani, Giuseppe Pacileo, Vittoria Mastromarino, Maria Letizia Bacchi Reggiani, Massimiliano Lorenzini, Francesco Lai, Alessandra Berardini, Francesca Mingardi Source Type: research

Watchful Waiting in Continuous-Flow Left Ventricular Assist Device Patients With Ongoing Hemolysis Is Associated With an Increased Risk for Cerebrovascular Accident or Death Original Articles
Conclusions— Hemolysis refractory to intensification of antithrombotic therapy identifies continuous-flow left ventricular assist device patients at major risk for CVA and death. Early device exchange should be considered to minimize these risks.
Source: Circulation: Heart Failure - May 9, 2016 Category: Cardiology Authors: Levin, A. P., Saeed, O., Willey, J. Z., Levin, C. J., Fried, J. A., Patel, S. R., Sims, D. B., Nguyen, J. D., Shin, J. J., Topkara, V. K., Colombo, P. C., Goldstein, D. J., Naka, Y., Takayama, H., Uriel, N., Jorde, U. P. Tags: Cardiovascular Surgery, Transplantation, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Preoperative optimization with levosimendan in heart failure patient undergoing thoracic surgery
Conclusion In this case the prophylactic preoperative levosimendan administration is safe and effective in cardiac failure patient undergoing thoracic surgery, but prophylactic preoperative levosimendan treatment in these patients merits further study.
Source: International Journal of Surgery Case Reports - August 3, 2016 Category: Surgery Source Type: research

Intramyocardially transplanted neonatal cardiomyocytes show structural and electrophysiological maturation and integration and dose-dependently stabilize function of infarcted rat hearts.
Abstract Cardiac cell replacement therapy is a promising therapy to improve cardiac function in heart failure. Persistence, structural and functional maturation and integration of transplanted cardiomyocytes into recipient's hearts are crucial for a safe and efficient replacement of lost cells. We studied histology, electrophysiology and quantity of intramyocardially transplanted rat neonatal cardiomyocytes (NCM) and performed a detailed functional study with repeated invasive (pressure-volume-catheter) and non-invasive (echocardiography) analyses of infarcted female rat hearts including pharmacological stress bef...
Source: Cell Transplantation - August 16, 2016 Category: Cytology Authors: Maass M, Krausgrill B, Eschrig S, Kaluschke T, Urban K, Peinkofer G, Plenge TG, Oeckenpöhler S, Raths M, Ladage D, Halbach M, Hescheler J, Müller-Ehmsen J Tags: Cell Transplant Source Type: research

Evaluation of the HeartWare ventricular assist device Lavare cycle in a particle image velocimetry model and in clinical practice TX & MCS
CONCLUSIONS The Lavare cycle effectively generates ventricular washout and the adverse event profiles of ReVOLVE patients with the Lavare cycle on were better than those with the Lavare cycle off. Larger studies are warranted to verify the positive effect of the Lavare cycle and to optimize speed modulation settings, so additional clinically relevant improvements can be realized.
Source: European Journal of Cardio-Thoracic Surgery - November 3, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Zimpfer, D., Strueber, M., Aigner, P., Schmitto, J. D., Fiane, A. E., Larbalestier, R., Tsui, S., Jansz, P., Simon, A., Schueler, S., Moscato, F., Schima, H. Tags: Peripheral vascular TX & amp; MCS Source Type: research

St. Jude Medical ’ s HeartMate 3 implantable pump beats HeartMate II in pivotal trial
The next-generation HeartMate 3 implantable pump St. Jude Medical (NYSE:STJ) acquired when it paid $3 billion for Thoratec last year proved superior to the older HeartMate II device at 6 months in pivotal clinical trial results released today. The Momentum 3 study enrolled more than 1,000 patients for a short-term outcome after 6 months and a longer-term, 2-year outcome; the initial 6-month data comes from 294 subjects. Unlike the HeartMate II device, which uses an axial-flow pump, the HeartMate 3 device uses a centrifugal-flow pump designed to reduce the risk of blood clots. The primary endpoint at 6 months was a compo...
Source: Mass Device - November 16, 2016 Category: Medical Equipment Authors: Brad Perriello Tags: Cardiac Assist Devices Cardiovascular Clinical Trials American Heart Assn. New England Journal of Medicine St. Jude Medical Thoratec Corp. Source Type: news