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Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice Basic Sciences
Conclusions— These data underscore the importance of hyperexcitability as a mechanism for increased stroke risk in migraineurs, and suggest that migraine prophylaxis may not only prevent migraine attacks but also protect migraineurs against ischemic injury.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Eikermann-Haerter, K., Lee, J. H., Yalcin, N., Yu, E. S., Daneshmand, A., Wei, Y., Zheng, Y., Can, A., Sengul, B., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Ayata, C. Tags: Neuroprotectors Basic Sciences Source Type: research

A Chinese Family With Adult-Onset Leigh-Like Syndrome Caused by the Heteroplasmic m.10191T > C Mutation in the Mitochondrial MTND3 Gene
Conclusion The m.10191T>C mutation in the mtDNA of the complex I (CI) subunit of MTND3 results in the substitution of a highly conserved amino acid (p.Ser45Pro) within the ND3 protein, leading to CI dysfunction through impaired enzyme catalysis rather than impaired stability or assembly, causing a broad clinical spectrum of disorders (26). Patients with the m.10191T>C mutation are rare. In the present study, we report on a family of patients with the extremely rare adult-onset Leigh-like syndrome with the m.10191T>C mutation. Including the two patients from our reported family, the m.10191T...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research

An Unusual Case of Episodic SUNCT Responding to High Doses of Topiramate
We report a case of episodic SUNCT with symptoms suggestive of brainstem stroke that completely resolved spontaneously for which no underlying structural cause was found. The onset of first attack occurred during orgasm, and the patient responded to a high dose of topiramate.
Source: Headache: The Journal of Head and Face Pain - September 1, 2014 Category: Neurology Authors: Modar Khalil, Farooq Maniyar, Fayyaz Ahmed Tags: Brief Communication Source Type: research

An Unusual Case of Episodic SUNCT Responding to High Doses of Topiramate.
We report a case of episodic SUNCT with symptoms suggestive of brainstem stroke that completely resolved spontaneously for which no underlying structural cause was found. The onset of first attack occurred during orgasm, and the patient responded to a high dose of topiramate. PMID: 25250729 [PubMed - as supplied by publisher]
Source: Headache - September 24, 2014 Category: Neurology Authors: Khalil M, Maniyar F, Ahmed F Tags: Headache Source Type: research

An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China
Conclusion Findings from this study provide extensive information on clinical characteristics and utilization of AEDs in Chinese patients with epilepsy which may help physicians make well-informed clinical decisions.
Source: Epilepsy and Behavior - February 23, 2017 Category: Neurology Source Type: research

An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China.
CONCLUSION: Findings from this study provide extensive information on clinical characteristics and utilization of AEDs in Chinese patients with epilepsy which may help physicians make well-informed clinical decisions. PMID: 28242476 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - February 23, 2017 Category: Neurology Authors: Yu P, Zhou D, Liao W, Wang X, Wang Y, Wang T, Wu Y, Lang S, Lin W, Song Y, Zhao H, Cai M, Hong Z Tags: Epilepsy Behav Source Type: research

Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks
AbstractPurpose of ReviewTo review the pathophysiologic, epidemiologic, and clinical evidence for similarities and differences between migraine with and without aura.Recent FindingsThe ICHD-3 has recently refined the diagnostic criteria for aura to include positive symptomatology, which better differentiates aura from TIA. Although substantial evidence supports cortical spreading depression as the cause of visual aura, the role (if any) of CSD in headache pain is not well understood. Recent imaging evidence suggests a possible hypothalamic origin for a headache attack, but further research is needed. Migraine with aura is ...
Source: Current Pain and Headache Reports - October 5, 2018 Category: Neurology Source Type: research

Post-stroke short-lasting unilateral neuralgiform headache attacks with autonomic symptoms (SUNA): response to lamotrigine and sphenopalatine ganglion block
Source: Clinical Autonomic Research - May 10, 2019 Category: Research Source Type: research

CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients
Eur J Paediatr Neurol. 2021 May 26;33:75-85. doi: 10.1016/j.ejpn.2021.05.010. Online ahead of print.ABSTRACTCACNA1A pathogenic mutations are involved in various neurological phenotypes including episodic ataxia (EA2), spinocerebellar ataxia (SCA6), and familial hemiplegic migraine (FHM1). Epilepsy is poorly documented. We studied 18 patients (10 males) carrying de novo or inherited CACNA1A mutations, with median age of 2,5 years at epilepsy onset. Eight mutations were novel. Two variants known leading to gain of function (GOF) were found in 5 patients. Five other patients had non-sense variants leading to loss of function ...
Source: European Journal of Paediatric Neurology - June 8, 2021 Category: Neurology Authors: Marie Le Roux Magalie Barth Sophie Gueden Patrick Desbordes de Cepoy Alec Aeby Catheline Vilain Edouard Hirsch Anne de Saint Martin Vincent des Portes Ga ëtan Lesca Audrey Riquet Laurence Chaton Nathalie Villeneuve Laurent Villard Claude Cances Luc Valto Source Type: research