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Here Are the Real Victims of Pakistan’s War on the Taliban
An elderly displaced man carries a sack of rations on his shoulder. The Pakistan Army has distributed 30,000 ration packs of 110 kg each. Credit: Ashfaq Yusufzai/IPSBy Ashfaq YusufzaiPESHAWAR, Pakistan, Jul 1 2014 (IPS) Three days ago, Rameela Bibi was the mother of a month-old baby boy. He died in her arms on Jun. 28, of a chest infection that he contracted when the family fled their home in Pakistan’s North Waziristan Agency, where a full-scale military offensive against the Taliban has forced nearly half a million people to flee. Weeping uncontrollable, Bibi struggles to recount her story. “My son was born on Jul. 2...
Source: IPS Inter Press Service - Health - July 1, 2014 Category: Global & Universal Authors: Ashfaq Yusufzai Tags: Aid Armed Conflicts Asia-Pacific Development & Aid Economy & Trade Editors' Choice Environment Featured Food & Agriculture Gender Headlines Health Human Rights Humanitarian Emergencies Migration & Refugees Population Povert Source Type: news

For most children with HIV and low immune cell count, cells rebound after treatment
UCLA Health Sciences Dr. Paul Krogstad Most children with HIV who have low levels of a key immune cell eventually recover levels of this cell after they begin treatment, according to a new study conducted by researchers at UCLA and other institutions in the U.S. and Brazil. The researchers were funded by the National Institutes of Health.  “We were pleased to find that the vast majority of children experience immune system recovery with effective therapy,” said Dr. Paul Krogstad, professor of pediatric infectious diseases and of molecular and medical pharmacology at the David Geffen School of Medicine at UCLA, and t...
Source: UCLA Newsroom: Health Sciences - March 26, 2015 Category: Universities & Medical Training Source Type: news

Deaf Adolescents' Learning of Cardiovascular Health Information: Sources and Access Challenges
Deaf individuals have more cardiovascular risks than the general population that are believed to be related to their cardiovascular health knowledge disparities. This phenomenological study describes where 20 deaf sign language-using adolescents from Rochester, New York, many who possess many positive characteristics to support their health literacy, learn cardiovascular health information and their lived experiences accessing health information. The goal is to ultimately use this information to improve the delivery of cardiovascular health education to this population and other deaf adolescents at a higher risk for weak h...
Source: Journal of Deaf Studies and Deaf Education - August 31, 2015 Category: Audiology Authors: Smith, S. R., Kushalnagar, P., Hauser, P. C. Tags: Empirical Manuscript Source Type: research

What It's Like When Your Mother Struggles With Major Anxiety
This article originally appeared on YourTango. More from YourTango: 5 Ways I Stay Happily Married To A Man With Chronic Anxiety 10 Things Your Friend Dealing With Anxiety Wants You To Know 10 Uplifting Quotes That Will Get You Through The Day A Guide To The BEST Birth Control For Every Type Of Woman Out There 7 Ways To Keep Their Passive-Aggression From Driving You Nuts Also on HuffPost: -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - November 6, 2015 Category: Consumer Health News Source Type: news

KCNQ potassium channels in sensory system and neural circuits.
Abstract M channels, an important regulator of neural excitability, are composed of four subunits of the Kv7 (KCNQ) K(+) channel family. M channels were named as such because their activity was suppressed by stimulation of muscarinic acetylcholine receptors. These channels are of particular interest because they are activated at the subthreshold membrane potentials. Furthermore, neural KCNQ channels are drug targets for the treatments of epilepsy and a variety of neurological disorders, including chronic and neuropathic pain, deafness, and mental illness. This review will update readers on the roles of KCNQ channe...
Source: Acta Pharmacologica Sinica - December 21, 2015 Category: Drugs & Pharmacology Authors: Wang JJ, Li Y Tags: Acta Pharmacol Sin Source Type: research

Experience Journal: Growing up with cerebral palsy
Cerebral palsy (CP) is the most common physical disability of childhood. The term CP is an umbrella term for a group of disorders that affect body movement and posture as a result of damage to a baby’s developing brain. There are many causes for CP, but all occur either during pregnancy, birth or shortly after birth. Common causes include differences in brain development, infection or stroke. Oxygen deprivation is accountable for only a small percentage of cases of CP; often, the cause is unknown. Although CP is a lifelong condition that can’t be reversed, children with the diagnosis can lead rich, fulfilling lives wit...
Source: Thrive, Children's Hospital Boston - March 18, 2016 Category: Pediatrics Authors: Erin Horan Tags: Experience Journal Cerebral Palsy Program Source Type: news

Acute cortical deafness in a child with MELAS syndrome
We report here an 11-year-old boy with MELAS syndrome who presented with subacute deafness after waking up from sleep. Peripheral hearing loss was rapidly excluded. A brain MRI documented bilateral stroke-like lesions predominantly affecting the superior temporal lobe, including the primary auditory cortex, confirming the central nature of deafness. Slow recovery was observed in the following weeks. This case serves to illustrate the numerous challenges caused by MELAS and the unusual occurrence of acute cortical deafness, that to our knowledge has not be described so far in a child in this setting.
Source: Journal of Inherited Metabolic Disease - April 6, 2016 Category: Internal Medicine Source Type: research

Three families with ‘de novo’ m.3243A>G mutation
In this report we describe these three families. Based on detailed mtDNA analysis of three different tissues using two different quantitative pyrosequencing assays with sensitivity to a level of 1% mutated mtDNA, we conclude that the m.3243A>G mutation has arisen de novo in each of these families. The symptomatic carriers presented with a variety of symptoms frequently observed in patients harbouring the m.3243A>G mutation. A more severe phenotype is seen in the de novo families compared to recent cohort studies, which might be due to reporting bias. The observation that de novo m.3243A>G mutations exi...
Source: BBA Clinical - April 29, 2016 Category: Biochemistry Source Type: research

Visual, Ocular Motor, and Cochleo-Vestibular Loss in Patients With Heteroplasmic, Maternally-Inherited Diabetes Mellitus and Deafness (MIDD), 3243 Transfer RNA Mutation
Conclusions: MIDD patients are primarily recognized by their advanced hearing loss or deafness, early onset diabetes mellitus, and lactic acidosis. Decreased vision in these patients relates primarily to peri-macular retinal atrophy. In addition, loss of vestibular function causes poor dynamic visual acuity. Both patients, in their late fifties, had evidence of progressive central and peripheral nervous system dysfunction.
Source: Journal of Neuro-Ophthalmology - June 1, 2016 Category: Opthalmology Tags: Original Contribution Source Type: research

Phenotypic Destiny in Mitochondrial Disease?
Mitochondrial diseases are a group of heterogeneous disorders caused by inherited mutations in the mitochondrial genome (mtDNA) and nuclear genome. Typically, mutations in the mtDNA are maternally inherited and cause respiratory chain defects and account for a substantial fraction of childhood and adult neurometabolic disease, with an estimated prevalence of 1:5000 (0.02%). The most common mtDNA mutation is the mitochondrial 3243A>G mutation (m.3243A>G) in the MTTL1 gene (OMIM 590050), which encodes the transfer RNA tRNALeu(UUR). This mutation is associated with multiple clinical and psychiatric manifestations, including d...
Source: JAMA Neurology - June 20, 2016 Category: Neurology Source Type: research

Three families with ‘de novo’ m.3243A & gt;G mutation
In this report we describe these three families. Based on detailed mtDNA analysis of three different tissues using two different quantitative pyrosequencing assays with sensitivity to a level of 1% mutated mtDNA, we conclude that the m.3243A>G mutation has arisen de novo in each of these families. The symptomatic carriers presented with a variety of symptoms frequently observed in patients harbouring the m.3243A>G mutation. A more severe phenotype is seen in the de novo families compared to recent cohort studies, which might be due to reporting bias. The observation that de novo m.3243A>G mutations exi...
Source: BBA Clinical - July 19, 2016 Category: Biochemistry Source Type: research

Teaching NeuroImages: Superficial siderosis due to a dural cervical arteriovenous fistula
A 58-year-old man presented to our hospital with cerebellar ataxia, pyramidal signs, dysarthria, bilateral deafness, and cognitive impairment. These symptoms were consistent with superficial siderosis (SS) of the CNS, confirmed by MRI (figure A).1 Cerebral angiography showed a dural arteriovenous fistula perispinal and pontic with venous drainage in the left foramen C1-C2, fed by meningeal branches of the vertebral artery (figure, B). The fistulous point was clipped. SS of CNS is a rare disease resulting from hemosiderin deposition on the surface of the CNS and cranial nerves.2 At diagnosis, the etiology may...
Source: Neurology - February 19, 2017 Category: Neurology Authors: Madkouri, R., Grelat, M. Tags: All Cerebrovascular disease/Stroke, All Spinal Cord, Arteriovenous malformation, Subarachnoid hemorrhage RESIDENT AND FELLOW SECTION Source Type: research

Kidney involvement in MELAS syndrome: Description of 2 cases.
CONCLUSION: The presence of FSGS or other kidney involvement accompanied by hereditary neurosensory deafness and T2DM could be suggestive of a A3243G tRNA(Leu) mutation and should prompt a genetic testing and an evaluation of potential extrarenal involvement. PMID: 28283275 [PubMed - as supplied by publisher]
Source: Medicina Clinica - March 12, 2017 Category: Journals (General) Tags: Med Clin (Barc) Source Type: research

A Cell-Based Assay to Assess Hemichannel Function.
Authors: Krishnan S, Fiori MC, Cuello LG, Altenberg GA Abstract Activation of connexin hemichannels is involved in the pathophysiology of disorders that include deafness, stroke, and cardiac infarct. This aspect makes hemichannels an attractive therapeutic target. Unfortunately, most available inhibitors are not selective or isoform specific, which hampers their translational application. The absence of a battery of useful inhibitors is due in part to the absence of simple screening assays for the discovery of hemichannel-active drugs. Here, we present an assay that we have recently developed to assess hemichannel ...
Source: The Yale Journal of Biology and Medicine - April 1, 2017 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research