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UK 'among worst' for cancer linked to obesity
Conclusion This international study has shown alarming increases in cases of cancer that can be attributed to high BMI. Overall, they estimated that 3.6% of cancers in adults (aged over 30 years) worldwide are caused by high BMI, with the proportion attributed to obesity slightly higher in women than in men. In the UK, 4.4% of all cases of cancer per year in men and 8.2% of all cases of cancer per year in women, were estimated to be attributable to obesity. The research focused on cancers that the WCRF has already established are linked to high BMI. When looking at these cancers, the UK was joint second highest in the worl...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Cancer Obesity Source Type: news

Presence of gallstones and the risk of cardiovascular diseases: The EPIC-Germany cohort study
Conclusions Our results indicate an increased cardiovascular risk for gallstone formers, which cannot be counteracted by gallbladder removal and opens up perspectives for individualized prevention strategies.
Source: European Journal of Preventive Cardiology - February 10, 2015 Category: Cardiology Authors: Wirth, J., Giuseppe, R. d., Wientzek, A., Katzke, V. A., Kloss, M., Kaaks, R., Boeing, H., Weikert, C. Tags: Original scientific papers Source Type: research

Long-term hormone therapy for perimenopausal and postmenopausal women.
CONCLUSIONS: Women with intolerable menopausal symptoms may wish to weigh the benefits of symptom relief against the small absolute risk of harm arising from short-term use of low-dose HT, provided they do not have specific contraindications. HT may be unsuitable for some women, including those at increased risk of cardiovascular disease, increased risk of thromboembolic disease (such as those with obesity or a history of venous thrombosis) or increased risk of some types of cancer (such as breast cancer, in women with a uterus). The risk of endometrial cancer among women with a uterus taking oestrogen-only HT is well docu...
Source: Cochrane Database of Systematic Reviews - January 16, 2017 Category: Journals (General) Authors: Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J Tags: Cochrane Database Syst Rev Source Type: research

Ezetimibe for the prevention of cardiovascular disease and all-cause mortality events.
CONCLUSIONS: Moderate- to high-quality evidence suggests that ezetimibe has modest beneficial effects on the risk of CVD endpoints, primarily driven by a reduction in non-fatal MI and non-fatal stroke, but it has little or no effect on clinical fatal endpoints. The cardiovascular benefit of ezetimibe might involve the reduction of LDL-C, total cholesterol and triglycerides. There is insufficient evidence to determine whether ezetimibe increases the risk of adverse events due to the low and very low quality of the evidence. The evidence for beneficial effects was mainly obtained from individuals with established atheroscler...
Source: Cochrane Database of Systematic Reviews - November 19, 2018 Category: General Medicine Authors: Zhan S, Tang M, Liu F, Xia P, Shu M, Wu X Tags: Cochrane Database Syst Rev Source Type: research

Adiponectin: a relevant player in obesity-related colorectal cancer?
Obesity is a condition characterised by an abnormally elevated mass of body fat. The past decades have seen a dramatic rise in the worldwide incidence of obesity due to lifestyle changes that have led to an overall reduced physical activity and an increase in the intake of excessive and/or highly caloric or processed foods. As a consequence, obesity represents nowadays a major global health concern. In particular, several epidemiological studies have linked obesity to a shortened lifespan due primarily to a higher risk for the development of chronic pathologies that include cardiovascular complications such as high blood p...
Source: Gut - February 28, 2013 Category: Gastroenterology Authors: Cava, A. L. Tags: Commentary Source Type: research

Multiple Ischemic Strokes Caused by Nonbacterial Thrombotic Endocarditis Because of Gallbladder Cancer: A Case Report
We report a case of a 62-year-old woman with multiple ischemic strokes caused by nonbacterial thrombotic endocarditis (NBTE) because of gallbladder cancer. Transesophageal echocardiography showed NBTE on the mitral valve. The NBTE disappeared with anticoagulation treatment for 2 weeks. Abdominal computed tomography showed a gallbladder tumor that was surgically resected. Histopathologic studies showed poorly differentiated tumor cells and the production of mucin. Trousseau syndrome with gallbladder cancer is very rare. We suggest that the development of NBTE is related to the production of mucin.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Akiko Yamane, Hirokazu Sadahiro, Hisaharu Goto, Akinori Inamura, Hideyuki Ishihara, Fumiaki Oka, Takayuki Oku, Tomoko Kondo, Michiyasu Suzuki Tags: Case Reports Source Type: research

Overweight and obesity on the island of Ireland: an estimation of costs
Conclusions The costs are substantial, and urgent public health action is required in Ireland to address the problem of increasing prevalence of overweight and obesity, which if left unchecked will lead to unsustainable cost escalation within the health service and unacceptable societal costs.
Source: BMJ Open - March 16, 2015 Category: Journals (General) Authors: Dee, A., Callinan, A., Doherty, E., O'Neill, C., McVeigh, T., Sweeney, M. R., Staines, A., Kearns, K., Fitzgerald, S., Sharp, L., Kee, F., Hughes, J., Balanda, K., Perry, I. J. Tags: Open access, Epidemiology, Health economics Research Source Type: research

Catching Dick: Not Why We Care About Weight
Amy Schumer said in her humorous acceptance speech at the Glamour Women of the Year Awards: "I'm like 160 pounds right now, and I can catch a dick whenever I want, and that's the truth." The line, like many in her speech, is obviously very funny. But the humor is directed at a misperception that is not so funny. With our society's superficial focus on youth and appearance, we have emphasized all the wrong reasons for maintaining a healthy body weight, which has nothing to do with "catching dick." We are sold the idea that remaining slim is primarily important as a means of attracting the opposite sex, rather than as a pa...
Source: Science - The Huffington Post - June 4, 2015 Category: Science Source Type: news

Therapeutic Indications and Action Mechanisms of Bilirubin: Suggestions from Natural Calculus Bovis
As a pathological product of bovine gallbladder, natural Calculus Bovis (CB) has a long history in Traditional Chinese Medicine to treat many diseases such as: stroke,coma, delirium, epilepsy, encephalitis B, etc. Experimental studies showed that natural CB had effects on central nervous system, cardiovascular system, inflammation, etc. Recent analyses confirmed that bilirubin composed the main proportion of all CB components. Preclinical researches demonstrated that bilirubin had ischemia protection, antiinflammation, anti-cancer, anti-virus, erythropoiesis, anti-pyretic, immune function protection, and cardiovascular eff...
Source: Current Signal Transduction Therapy - June 21, 2016 Category: Molecular Biology Source Type: research

Excess body fat now linked to 13 different types of cancer
"Experts have linked eight more cancers to being overweight or obese, nearly tripling the list from five to 13," the Daily Mail reports. This is the latest finding of the International Agency for Research on Cancer (IARC), a group of cancer experts from around the world that look at risk factors for cancer.  What is the basis for these reports? The headlines are based on a report published in the peer-reviewed New England Journal of Medicine. The report is not exactly new research, but a review of previously published studies that looked at the link between weight and cancers. It is the result of a working g...
Source: NHS News Feed - August 25, 2016 Category: Consumer Health News Tags: Cancer Obesity Lifestyle/exercise Source Type: news

Variation of all-cause and cause-specific mortality with body mass index in one million Swedish parent-son pairs: An instrumental variable analysis
ConclusionsConsistent with previous large-scale meta-analyses and reviews, results supported the causal role of higher BMI in increasing the risk of several common causes of death, including cancers with increasing global incidence. We also found positive effects of BMI on mortality from respiratory disease, prostate cancer, and lung cancer, which has been inconsistently reported in the literature, suggesting that the causal role of higher BMI in mortality from these diseases may be underestimated. Furthermore, we expect different patterns of bias in the current observational and IV analyses; therefore, the similarities be...
Source: PLoS Medicine - August 8, 2019 Category: Internal Medicine Authors: Kaitlin H. Wade Source Type: research

Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry
ConclusionAlthough the survival of LS patients with PC or BTC is better than in sporadic cancers, it is still poor and may be reflected by the relatively higher surgical resectability accounted for by the earlier age of onset. More studies on analyses of the molecular and immune profile, screening, and management of LS-associated pancreaticobiliary cancers are warranted.
Source: Frontiers in Oncology - February 1, 2023 Category: Cancer & Oncology Source Type: research