Implementation of Neural Network with ALE for the Removal of Artifacts in EEG Signals
Conclusion: Experiments show that this method can get high and accurate rate of classification. In this paper, it is proposed that a low-cost use of Field Programmable Gate Arrays (FPGAs) can be used to process EEG signals for extracting and denoising. As a preliminary study, this work shows the implementation of a Neural Network, integrated with ALE for EEG signal processing. The preliminary tests through the proposed architecture for the activation function shows to be reasonable both in terms of precision and in processing speed. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

A New Approach of Position Sensorless Control for Brushless DC Motor
Conclusion: Field Programmable Gate Array (FPGA) is used to implement the proposed method. Experimental results verify the analysis and demonstrate the advantages of the proposed method. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Black Hole Attack Detection in Healthcare Wireless Sensor Networks Using Independent Component Analysis Machine Learning Technique
Conclusion: The black hole attack isolation is then performed through the distribution of the attack separation message. This supports to improve Packet Delivery Ratio (PDR) with minimum delay. The simulation is carried out based on parameters such as black hole attack detection rate (BHADR), Black Hole Attack Detection Time (BHADT), False Positive Rate (FPR), PDR and delay. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Efficient Spectral Allocation for Cognitive Full Duplex Relay Network Systems Based Soft Computing Technique
Conclusion: The performance results of the proposed method are evaluated in terms of spectral allocation and outage probability which achieves better performance than the existing Multi- Objective Genetic Algorithm (MOGA) optimization. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Channel Scheduling Based on Orchestrator Live Node-Wavelength Reservation for Optical Burst Switching Networks
Conclusion: The controlling of maximum burst transfer delay by the OTBA efficiently reduces the end-to-end delay for data traffic. The comparative analysis between the proposed OLN-WR with the existing Hybrid Burst Assembly (HBA), Fuzzy-based Adaptive Threshold (FAT) and Fuzzy-based Adaptive Hybrid Burst Assembly (FAHBA) in terms of end-to-end delay and transmitted amount of bursts assures the applicability of OLN-WR in scheduling and communication activities in OBS networks. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Genetic Algorithm to Evaluate Downstream and Upstream Information Sharing
Conclusion: Our approach is illustrated by some numerical experiments. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Kinase Phosphorylation-based Mechanisms of PARP Inhibitor Resistance During Synthetic Lethal Oncotherapy
Conclusion: These kinase-based signaling pathways are biologically important for understanding the compensatory system of HR, whereas inactivation of these kinases has shown promise for the release of PARPi resistance. Several lines of preclinical studies have demonstrated the potential use of kinase inhibitors to enhance PARPi sensitivity. We emphasize the clinical importance of chemical inhibitors as adjuvant drugs to block critical kinase activities and prevent the possible PARPi resistance. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Abnormal Signal Transduction via Over-expression of Pim-1 Regulated Senescence, Cell Cycle, Apoptosis and Metastatic Invasion: Novel Anticancer Targets and Their Potent Inhibitors from Marine Sources
Conclusion: Existed marine sourced anticancer compounds tabulated in this study could be used as a template for further design and synthesis of promising congeneric synthetic compounds against another disease by the application of in silico high throughput screening through drug repositioning. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Meet Our Editorial Board Member
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Preface
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - July 31, 2020 Category: Molecular Biology Source Type: research

Acknowledgements to Reviewers
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Identifying User Suitability in sEMG Based Hand Prosthesis Using Neural Networks
Conclusion: In this paper a study was conducted to identify user suitability for designing hand prosthesis. Data were collected from ten subjects for twelve tasks related to finger movements. The suitability of the user was identified using two neural networks with six parametric features. From the result, it was concluded thatfit women doing regular physical exercises aged between 26-30 years are best suitable for developing HMI for designing a prosthetic hand. Pattern Recognition Neural Network with AR Burg extraction features using extension movements will be a better way to design the HMI. However, Signal acquisition b...
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

A Hybrid Security System Based on Bit Rotation and Chaotic Maps
Conclusion: The performance of the proposed technique is evaluated using several metrics: Histograms of both original and cipher images, correlation of adjacent pixels and correlation between the original and cipher images, Number of Pixel Change Rate (NPCR), Unified Average Changing Intensity (UACI), Mean Square Error (MSE), and Peak Signal to Noise Ratio (PSNR). The results indicate a very secure technique to protect all types of images. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

A Grayscale Image Hiding Encode Scheme for Secure Transmission
Conclusion: To evaluate the proposed MSI encoding process the time, signal to noise ratio, complexity and strength are considering as the parameters. In result, the MSI encode technique is providing good reconstruction image quality, strong against the pixel attack and HVA, less execution time than the conventional schemes. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Synchronization Based on Node Balance Set for Energy Conservation in Wireless Sensor Networks
Conclusion: Hypothetical study and experimental simulations are studied by various performance evaluation metrics namely clock offset, number of transmitted messages, delayed messages and Residual Energy. The results confirm that clustering with node balance set saves more energy in WSN and also it reduces synchronization errors. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

To Minimize Fault Report and Bug Fixing Time using an Efficient Integration of Instance and Aspect Preferment Algorithm
Conclusion: The proposed technique helps to validate & verify software application in effective way. Reduction of data on fault triage aims to construct a high-superiority set of fault data in the small-scale system through eliminating the fault report. To applying an algorithm, fault data set and attributes are extracted from every fault data set and train a predictive model based on the historical dataset. Based on Experimental evaluations, proposed methodology reduces 0.06 ET (Execution Time), and improves 0.5 P (Precision), 0.75 R (Recall), 0.39 F-M (F-Measure) and 5.07% (accuracy) compared than existing methodolog...
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Recent Innovations in Soft Computing Applications
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Current Therapy and Computational Drug Designing Approaches for Neurodegenerative Diseases -with Focus on Alzheimer’s and Parkinson’s.
Conclusion: The findings of this review confirm that therapies and current successful strategies for neurodegenerative disease are mainly symptomatic. Current research is mainly focused on preventing the progress of neurodegeneration. Various in silico techniques; ligand-based methods such as QSAR, virtual screening, pharmacophore mapping and structure-based methods such as homology modeling, docking studies have been used to identify therapeutic compounds for Alzheimer’s and Parkinson’s. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Novel Target Sites for Drug Screening: A Special Reference to Cancer, Rheumatoid Arthritis and Parkinson’s Disease
Conclusion: Alteration of signal transduction by a drug is the goal of chemogenomics, a new branch formed by combination of chemistry and genomics. The proliferation, angiogenesis and apoptosis of cancer cells are regulated by cellular signaling of transcription factors, protein kinases, transmembrane receptors, extracellular ligands and some external factors like oncogenic mutations, ubiquitin-proteasome pathway with epigenetic changes. Traditional anticancer drugs either alter DNA synthesis or control cell division while new drugs retard tumor growth or induce apoptosis. The deterioration of dopaminergic neurons in subst...
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

1,3,5-Triazine Analogs: A Potent Anticancer Scaffold
Conclusion: Various 1,3,5-triazine analogs have shown potent activities and may be regarded as clinical candidates for future anticancer formulations. This review may be helpful to those researchers seeking required information with regard to the drug design and medicinal properties of 1,3,5-triazine derivatives for selected targets. This review may also offer help to find and improve clinically viable anticancer molecules. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Recent Drug Targets Associated to Abnormal Signal Transduction Mediated Cancer, Rheumatoid Arthritis, Alzheimer’s and Parkinson’s disease
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Meet Our Editorial Board Member
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - June 30, 2020 Category: Molecular Biology Source Type: research

Acknowledgements to Reviewers
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Identifying User Suitability in sEMG Based Hand Prosthesis Using Neural Networks
Conclusion: In this paper a study was conducted to identify user suitability for designing hand prosthesis. Data were collected from ten subjects for twelve tasks related to finger movements. The suitability of the user was identified using two neural networks with six parametric features. From the result, it was concluded thatfit women doing regular physical exercises aged between 26-30 years are best suitable for developing HMI for designing a prosthetic hand. Pattern Recognition Neural Network with AR Burg extraction features using extension movements will be a better way to design the HMI. However, Signal acquisition b...
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

A Hybrid Security System Based on Bit Rotation and Chaotic Maps
Conclusion: The performance of the proposed technique is evaluated using several metrics: Histograms of both original and cipher images, correlation of adjacent pixels and correlation between the original and cipher images, Number of Pixel Change Rate (NPCR), Unified Average Changing Intensity (UACI), Mean Square Error (MSE), and Peak Signal to Noise Ratio (PSNR). The results indicate a very secure technique to protect all types of images. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

A Grayscale Image Hiding Encode Scheme for Secure Transmission
Conclusion: To evaluate the proposed MSI encoding process the time, signal to noise ratio, complexity and strength are considering as the parameters. In result, the MSI encode technique is providing good reconstruction image quality, strong against the pixel attack and HVA, less execution time than the conventional schemes. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Synchronization Based on Node Balance Set for Energy Conservation in Wireless Sensor Networks
Conclusion: Hypothetical study and experimental simulations are studied by various performance evaluation metrics namely clock offset, number of transmitted messages, delayed messages and Residual Energy. The results confirm that clustering with node balance set saves more energy in WSN and also it reduces synchronization errors. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

To Minimize Fault Report and Bug Fixing Time using an Efficient Integration of Instance and Aspect Preferment Algorithm
Conclusion: The proposed technique helps to validate & verify software application in effective way. Reduction of data on fault triage aims to construct a high-superiority set of fault data in the small-scale system through eliminating the fault report. To applying an algorithm, fault data set and attributes are extracted from every fault data set and train a predictive model based on the historical dataset. Based on Experimental evaluations, proposed methodology reduces 0.06 ET (Execution Time), and improves 0.5 P (Precision), 0.75 R (Recall), 0.39 F-M (F-Measure) and 5.07% (accuracy) compared than existing methodolog...
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Recent Innovations in Soft Computing Applications
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Current Therapy and Computational Drug Designing Approaches for Neurodegenerative Diseases -with Focus on Alzheimer’s and Parkinson’s.
Conclusion: The findings of this review confirm that therapies and current successful strategies for neurodegenerative disease are mainly symptomatic. Current research is mainly focused on preventing the progress of neurodegeneration. Various in silico techniques; ligand-based methods such as QSAR, virtual screening, pharmacophore mapping and structure-based methods such as homology modeling, docking studies have been used to identify therapeutic compounds for Alzheimer’s and Parkinson’s. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Novel Target Sites for Drug Screening: A Special Reference to Cancer, Rheumatoid Arthritis and Parkinson’s Disease
Conclusion: Alteration of signal transduction by a drug is the goal of chemogenomics, a new branch formed by combination of chemistry and genomics. The proliferation, angiogenesis and apoptosis of cancer cells are regulated by cellular signaling of transcription factors, protein kinases, transmembrane receptors, extracellular ligands and some external factors like oncogenic mutations, ubiquitin-proteasome pathway with epigenetic changes. Traditional anticancer drugs either alter DNA synthesis or control cell division while new drugs retard tumor growth or induce apoptosis. The deterioration of dopaminergic neurons in subst...
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

1,3,5-Triazine Analogs: A Potent Anticancer Scaffold
Conclusion: Various 1,3,5-triazine analogs have shown potent activities and may be regarded as clinical candidates for future anticancer formulations. This review may be helpful to those researchers seeking required information with regard to the drug design and medicinal properties of 1,3,5-triazine derivatives for selected targets. This review may also offer help to find and improve clinically viable anticancer molecules. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Recent Drug Targets Associated to Abnormal Signal Transduction Mediated Cancer, Rheumatoid Arthritis, Alzheimer’s and Parkinson’s disease
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Meet Our Editorial Board Member
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - October 10, 2019 Category: Molecular Biology Source Type: research

Design and Evaluation of a Modulated TENS Stimulation in Medical Pain Therapy
Conclusion: The first results clinically observed in the PWM-TENS technique are encouraging. The findings of this study confirm that this noninvasive strategy is suitable and useful for acute pains coming from the nociceptive, neuropathic and musculoskeletal origin. However, its efficiency is moderated and less adapted for low back pain. The experiments make it possible to estimate whether this modulated TENS method could improve existing anti-pain therapies, taking into account objective and subjective evaluation criteria. But this study must be followed by large population samples to answer all the problems of acute and ...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

IoT based Low Power Wearable ECG Monitoring System
Conclusion: We have proposed a wireless wearable ECG monitoring system enabled with an IoT platform that integrates heterogeneous nodes of ECG sensor and applications, has a long battery life and provides a high-quality ECG signal. The system allows monitoring single/multiple patients on a relatively large indoor area (home, building, nursing home, etc). As observed, this result is obtained through a careful set of choices at the level of components, circuit solutions, and algorithms. We would like to stress the fact that a dedicated overall output is not enough to achieve an advantage in terms of overall sensor performanc...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Proteome Analysis Revealed Jak/Stat Signaling and Cytoskeleton Rearrangement Proteins in Human Lung Epithelial Cells During Interaction with Aspergillus terreus
Conclusion: Our study has contributed to understand the interaction response of human lung epithelial cells during A. terreus infection. Also, our study may facilitate the identification of inflammatory biomarker against A. terreus. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Targeting Negative Regulators of TRIF-dependent TLR Signaling Pathway as a Novel Therapeutic Strategy
Conclusion: We proposed that the manipulation of TRIF signaling pathway via targeting its negative regulators could be used as an approach to modulate the functions of this pathway without undesired toxic proinflammatory responses. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

ANN-based Maximum Power Point Tracking for a Large Photovoltaic Farm Through Wireless Sensor Networks
Conclusion: A wireless network based insulation monitoring has been done. An ANN based MPPT algorithm has been developed that gives the reference MPP voltage. The sliding mode control scheme uses the reference voltage and produces the switching pulses for the POLC. The ANN had been trained with a number of combinations of different insulation values falling on each of the forty panels and the ANN gives the correct reference voltage for any combination of insulation levels that were not used while training. The sliding mode controller uses this reference voltage and gives the switching pulses to the POLC that harvests the m...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Design and Implementation of High Power LED Lighting System for Health Care Applications
Conclusion: This manuscript suggests a modified single switch SEPIC LED driver for 48V output operated healthcare equipment. Simulation study of this driver shows the better performance. In order to analyze the performance, a comparative study was conducted by using the classical PI and the novel PI integrated fuzzy controller. Satisfactory results regarding enhanced quality of power, regulated load voltage, quick rise time and settling time were achieved. The source current THD has been reduced to around 1.39% which is less than 5% as per the IEEE-516 prescribed standard and the power factor has been improved to 0.9995 by...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Anfis Classifier Based Moving Object Detection and Segmentation in Indoor and Outdoor Environments
Conclusion: In this paper, moving object is detected and segmented using ANFIS classifier. The proposed method initially segments the background image and then features are extracted from the threshold image. These features are trained and classified using ANFIS classification method. The proposed moving object detection method is tested on different video sequences which are obtained from different indoor and outdoor environments. The performance of the proposed moving object detection and segmentation methodology is analyzed in terms of Accuracy, Recall, Average Accuracy, Precision and F-measure. (Source: Current Signal ...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Application of Evolutionary Algorithms for Harmonic Profile Optimization in Symmetric Multilevel Inverter used in Medical Electronic Equipments
Conclusion: The proposed symmetric MLI with evolutionary algorithm based switching is a good choice for medical electronic equipment used in hospital to obtain quality power with minimum THD. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Optimal Placement of FACTS Devices for Voltage Stability Improvement with Economic Consideration Using Firefly Algorithm
Conclusion: The optimal placement, rating and cost of installation of TCSC and SVC in standard IEEE bus systems which enhanced the voltage stability were evaluated in this work. The need of the FACTS devices was also tested during the abnormal cases such as line outage case, generator outage case and overloading case (140%) with the proposed Firefly algorithm. Outputs reveal that the recognized placement of SVC and TCSC reduces the probability of voltage collapse and cost of the devices in the transmission lines. The capability of Firefly algorithm was also ensured by comparing its results with the results of other algorit...
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Real time Processing in Control, Computer Vision and Power Electronics
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Preface
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Meet Our Editorial Board Member
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - March 11, 2019 Category: Molecular Biology Source Type: research

Acknowledgements to Reviewers
(Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Comparison of Surface Electromyogram Signal for Prosthetic Applications
Conclusion: Finally, the simulation study based on muscle modeling allowed us to explore the parameters that affect the muscle-force relationship prior to prostheses design. Further, the proposed study will also help researchers in understanding the nature of these complex signals particularly in biomedical applications. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Performance Analysis of LCL-T Filter Based 2 Stage Single Phase Gird Connected Module with ANN Controller using PV Panel
Conclusion: Hence the paper depicts the structure of non-holonomic robotic vehicle and control with the help of PID controller. The parallel parking scheme has established using MATLAB programming and verified with the help of real time prototype. The paper proposed an idea of automated parking system in contrast to manual parking by the driver. The consumption of space, energy and time are minimized due to the automated parking scheme. Due to human error and negligence, harms such as collisions and accidents are occurred. These harms are reduced by implementing the parallel parking scheme in an intelligent manner. In futu...
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research

Chimeric Antigen Receptors; Their Current and Futuristic Scope
Conclusion: Amongst the most novel approaches, the CAR based research should be focussed on effective tumor targeting with limited toxicity in normal tissues, to improve efficacy with modulation of cell products or host cell products for rapid in vivo expansion. (Source: Current Signal Transduction Therapy)
Source: Current Signal Transduction Therapy - September 19, 2018 Category: Molecular Biology Source Type: research