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Cancer: Head and Neck Cancer
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Total 69 results found since Jan 2013.

A nomogram for the prediction of cerebrovascular disease among patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma
In various cancer populations, radiotherapy is associated with the development of vascular disease [1 –4]. Previous studies have established an increased incidence of carotid stenosis (CAS) and ischemic stroke in patients with head and neck cancer treated with radiotherapy [4,5]. A study of 6862 patients (age>65  years) showed that five-year incidence of cerebrovascular events was 19% in patients treated with radiotherapy alone compared with 14% in patients treated with surgery plus radiotherapy; the corresponding ten-year incidence were 34% and 25%, respectively [4].
Source: Radiotherapy and Oncology - December 21, 2018 Category: Radiology Authors: Jinhua Cai, Jinping Cheng, Honghong Li, Wei-Jye Lin, Yi Li, Xiaohuang Zhuo, Xiaolong Huang, Charles B. Simone, Wilbert S. Aronow, Edward L.W. Chow, Yamei Tang Tags: Original Article Source Type: research

Saliva-Omics in Plasma Cell Disorders -- Proof of Concept and Potential As a Non-Invasive Tool for Monitoring Disease Burden and MRD Status
This study provides proof of concept that a range of biologically significant proteins of interest can be reliably detected in the saliva of MM and MGUS patients. The observation of differential expression of FABP5 between MGUS and MM identified these as candidate proteins relevant to malignant transformation of MGUS to symptomatic MM. The demonstration of decreased abundance of FABP5 after achieving remission indicates a correlation with tumour burden. This opens the opportunity to explore candidate salivary biomarkers for use in the clinic for disease monitoring and Minimal Residual Disease (MRD) assessment.DisclosuresNo...
Source: Blood - November 21, 2018 Category: Hematology Authors: Tierney, C., Bazou, D., Le, G., Dowling, P., O'Gorman, P. Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster II Source Type: research

Neurologic manifestations of elderly patients with cancer.
CONCLUSION: Identifying the frequency and correlation of neurologic manifestations in older cancer patients will allow for the implementation of timely multidisciplinary care in an attempt to improve these patients' health-related quality of life. PMID: 29704209 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - April 27, 2018 Category: Geriatrics Authors: Cacho-Díaz B, Lorenzana-Mendoza NA, Reyes-Soto G, Ávila-Funes JA, Navarrete-Reyes AP Tags: Aging Clin Exp Res Source Type: research

Radiation-induced carotid artery lesions
ConclusionsRadiation-induced atherosclerosis is a  different and accelerated form of atherosclerosis, which implies a more aggressive disease with a different biologic behavior. The disease is characterized by a high rate of carotid artery stenosis compared to those observed in nonirradiated control group patients. To prevent the risk of stroke , surveillance and imaging with ultrasonography should enable detection of severe stenosis. Endovascular treatment with a carotid angioplasty and stenting has been proposed as an attractive and minimally invasive alternative for some radiation-induced stenoses.
Source: Strahlentherapie und Onkologie - April 20, 2018 Category: Cancer & Oncology Source Type: research

Safety and effectiveness of endovascular embolization or stent ‐graft reconstruction for treatment of acute carotid blowout syndrome in patients with head and neck cancer: Case series and systematic review of observational studies
ConclusionBoth embolization and stent grafts are safe therapeutic options for acute carotid blowout syndrome. Embolization for ICA/CCA carotid blowout syndrome was associated with higher risks of procedural stroke and lower recurrent bleeding compared to stent grafts.
Source: Head and Neck - November 20, 2017 Category: ENT & OMF Authors: Daniel J. Y. Wong, Christopher Donaldson, Leon T. Lai, Andrew Coleman, Charles Giddings, Lee ‐Anne Slater, Ronil V. Chandra Tags: CLINICAL REVIEW Source Type: research

Association between radioiodine treatment for thyroid cancer and risk of stroke
ConclusionThe I‐131 treatment for thyroid cancer did not increase the risk of stroke during 10‐year follow‐up.
Source: Head and Neck - August 16, 2017 Category: ENT & OMF Authors: Chun ‐Yi Lin, Cheng‐Li Lin, Yi‐Chen Lo, Chia‐Hung Kao Tags: ORIGINAL ARTICLE Source Type: research

Free Tissue Transfers for Head and Neck Reconstruction in Patients with End-Stage Renal Disease on Dialysis: Analysis of Outcomes Using the Taiwan National Health Insurance Research Database
Conclusion Despite greater preoperative risk factors, patients with renal failure on hemodialysis do not appear to have a higher rate of free flap failure following head and neck reconstruction. However, other complications can be minimized by optimizing patient's medical condition to succeed with this reconstructive effort. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Reconstructive Microsurgery - June 16, 2017 Category: Surgery Authors: Manrique, Oscar J. Ciudad, Pedro Sharaf, Basel Martinez-Jorge, Jorys Moran, Steven Mardini, Samir Chen, Hung-Chi Bite, Uldis Cheng, Hsu-Tang Tags: Original Article Source Type: research

Evaluating the Primary Prevention of Ischemic Stroke of Oral Antithrombotic Therapy in Head and Neck Cancer Patients with Radiation Therapy.
Abstract Although previous studies demonstrated the risk of ischemic stroke (IS) in patients with head and neck cancer (HNC), the impact of oral antithrombotic therapy (OAT) on this risk has not yet been assessed. We aimed to evaluate the effectiveness and safety of OAT in patients with HNC treated with RT. This retrospective cohort study was performed using the National Health Insurance Research Database of Taiwan. A total of 37,638 patients diagnosed with HNC included in the study were classified as users and nonusers of OAT. Primary outcome was IS or transient ischemic attack (TIA), and secondary outcomes were ...
Source: Biomed Res - December 20, 2016 Category: Research Authors: Hsu CW, Huang YB, Kuo CC, Chen CY Tags: Biomed Res Int Source Type: research

Portable disposable ultrathin endoscopy tested through percutaneous endoscopic gastrostomy
Conclusions: Our study shows that portable DUE in facilities without endoscopy equipment may be clinically feasible.
Source: Medicine - November 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Cardiac comorbidity in head and neck cancer patients and its influence on cancer treatment selection and mortality: a prospective cohort study
AbstractComorbidity assessment and a profound cardiac examination were implemented into pre-treatment diagnostics to analyze their influence on head and neck squamous cell carcinoma (HNSCC) therapy selection and short-term mortality. Comorbidity was measured prospectively in 49 HNSCC patients using standard indices between 2012 and 2013. Cardiac examinations included electrocardiogram, echocardiography, and bicycle ergometry. Most patients had stage IV tumors (61  %), smoked (61 %), and showed alcohol abuse (57 %); 38 patients (78 %) received a multimodal therapy; 65 % had an adult comorbidity evaluation 27 index ≥2...
Source: European Archives of Oto-Rhino-Laryngology - August 4, 2016 Category: ENT & OMF Source Type: research

Neck dissection and stroke in patients with oral cavity cancer: A population ‐based cohort study
ConclusionOur data demonstrate that neck dissection does not increase the risk of stroke in patients with oral cavity cancer. Patients have higher risk of stroke after cancer treatment because of their older age, specific comorbidities, and/or type of postoperative treatment. © 2016 Wiley Periodicals, Inc. Head Neck, 2016
Source: Head and Neck - July 19, 2016 Category: ENT & OMF Authors: Chia ‐Fan Chang, Yen‐Ling Kuo, Christy Pu, Yiing‐Jenq Chou Tags: Original Article Source Type: research

Neck dissection and stroke in patients with oral cavity cancer: A population‐based cohort study
ConclusionOur data demonstrate that neck dissection does not increase the risk of stroke in patients with oral cavity cancer. Patients have higher risk of stroke after cancer treatment because of their older age, specific comorbidities, and/or type of postoperative treatment. © 2016 Wiley Periodicals, Inc. Head Neck, 2016
Source: Head and Neck - July 19, 2016 Category: ENT & OMF Authors: Chia‐Fan Chang, Yen‐Ling Kuo, Christy Pu, Yiing‐Jenq Chou Tags: Original Article Source Type: research

Stroke after Radiotherapy for Head and Neck Cancer – What is the Risk?
Treating head and neck squamous cell carcinomas with radiotherapy has been shown to cause damage to the cerebrovasculature. This retrospective cohort study found that any exposure to radiation was associated with a 46% higher hazard of stroke, and with radiotherapy as the sole treatment modality, 70% increased risk of stroke compared to surgery alone. Implications of this research speak to the need for adequate follow-up and survivorship care among patients that were treated with RT.
Source: International Journal of Radiation Oncology * Biology * Physics - July 15, 2016 Category: Radiology Authors: Erin Arthurs, Timothy P. Hanna, Khaled Zaza, Yingwei Peng, Stephen F. Hall Source Type: research

Stroke After Radiation Therapy for Head and Neck Cancer: What Is the Risk?
A retrospective population-based cohort study was conducted to determine the risk of ischemic stroke with respect to time, associated with curative radiation therapy in head and neck squamous cell carcinomas (HNSCC).
Source: International Journal of Radiation Oncology * Biology * Physics - July 15, 2016 Category: Radiology Authors: Erin Arthurs, Timothy P. Hanna, Khaled Zaza, Yingwei Peng, Stephen F. Hall Tags: Clinical Investigation Source Type: research