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Total 403 results found since Jan 2013.

wEight chanGes, caRdio-mEtabolic risks and morTality in patients with hyperthyroidism (EGRET): a protocol for a CPRD-HES linked cohort study
Introduction Hyperthyroidism is a common condition affecting up to 3% of the UK population. Treatment improves symptoms and reduces the risk of atrial fibrillation and stroke that contribute to increased mortality. The most common symptom is weight loss, which is reversed during treatment. However, the weight regain may be excessive, contributing to increased risk of obesity. Current treatment options include antithyroid drugs, radioiodine and thyroidectomy. Whether there are differences in either weight change or the long-term cardiometabolic risk between the three treatments is unclear. Methods and analysis The study wi...
Source: BMJ Open - October 1, 2021 Category: General Medicine Authors: Torlinska, B., Hazlehurst, J. M., Nirantharakumar, K., Thomas, G. N., Priestley, J. R., Finnikin, S. J., Saunders, P., Abrams, K. R., Boelaert, K. Tags: Open access, Diabetes and Endocrinology Source Type: research

Malnutrition Prevalence Rates among Dutch Nursing Home Residents: What Has Changed over One Decade? A Comparison of the Years 2009, 2013 and 2018
ConclusionEven though much attention has been paid to prevent malnutrition in Dutch nursing homes over the last decades, results show a relatively stable malnutrition prevalence rate of around 16%. This leads to the question if nursing staff is able to sufficiently recognize residents with (a risk of) malnutrition, and if they are aware of interventions they could perform to decrease this rate.
Source: The Journal of Nutrition, Health and Aging - September 4, 2021 Category: Nutrition Source Type: research

Long-Term Body Mass Index Variability, Weight Change Slope, and Risk of Cardiovascular Outcomes: 7-Year Prospective Study in Chinese Hypertensive Subjects
Conclusions: Higher BMI variability was associated with increased risk of CVD in hypertensive subjects with weight gain but not in those with weight loss, independent of traditional cardiovascular risk factors.Obes Facts
Source: Obesity Facts - August 30, 2021 Category: Eating Disorders & Weight Management Source Type: research

Association Between Weight Loss and Activities of Daily Living in Obese and Overweight Patients after Stroke: A Cross-Sectional Study
Obesity is an important issue in global health care. Between 1975 and 2016, the proportion of obese individuals in the world nearly tripled. In fact, 39% of adults aged 18 years and older were overweight in 2016 and 13% were obese, using the traditional definition of overweight and obesity, namely, a body mass index (BMI)> 25 kg/m2 and> 30 kg/m2, respectively.1 Obesity is associated with a significant increase in mortality2,3 and the risk of many disorders, including metabolic and cardiovascular disease,4 cancer,5 infection,6 and physical limitations,7 as well as increasing healthcare costs.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2021 Category: Neurology Authors: Yoji Kokura, Shinta Nishioka Source Type: research

Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice
In this study, ICH was induced in C57BL/6 J mice by injection of collagenase VII, while the overexpression of Nrn in the striatum was induced by an adeno-associated virus serotype 9 (AAV9) vector. We found that compared with GFP-ICH mice, Nrn-ICH mice showed improved performance in the corner, cylinder and forelimb tests after ICH, and showed less weight loss and more rapid weight recovery. Overexpression of Nrn reduced brain lesions, edema, neuronal death and white matter and synaptic integrity dysfunction caused by ICH. Western blot results showed that phosphorylated PERK and ATF4 were significantly inhibited, while phos...
Source: Neurobiology of Disease - May 31, 2021 Category: Neurology Authors: Junmei Lu Zhaoyang Li Qianru Zhao Dongdong Liu Yan-Ai Mei Source Type: research

Potential impact of gradual reduction of fat content in manufactured and out-of-home food on obesity in the United Kingdom: a modeling study
ConclusionsA modest fat reduction (particularly in SFA) in widely consumed foods would prevent obesity, type 2 diabetes, and cardiovascular disease.
Source: American Journal of Clinical Nutrition - May 8, 2021 Category: Nutrition Source Type: research

O27  Frailty and co-morbidity in people with osteoarthritis and rheumatoid arthritis
Conclusion Co-morbidity is associated with an increased occurrence of pre-frailty and frailty among people with OA and RA and interacts synergistically with OA and RA to increase the likelihood of pre-frailty and frailty.Disclosure M.J. Cook: None.M. Lunt: None.S.M.M. Verstappen: None.T.W. O'Neill: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

P030  Antiphospholipid syndrome and giant cell arteritis: a coincidence or connection?
Conclusion In summary, this is a case of GCA and APS, treated with prednisolone, aspirin, warfarin and tocilizumab. There is increasing evidence describing the presence of antiphospholipid antibodies in patients with vasculitis. However, the role of these antibodies in GCA and the clinical significance rema ins unclear. This case reports highlights the need for physicians to consider APS in patients who have a history of GCA and subsequently develop arterial or venous embolic events.Disclosure L. Sammut: None.E. Htut: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Supervised Obesity Reduction Trial for AF ablation patients: results from the SORT-AF trial
ConclusionThe SORT-AF study shows that AF ablation is safe and successful in obese patients using continuous monitoring via ILR. Although the primary endpoint of AF burden after ablation did not differ between the two groups, the effects of weight loss and improvement of exercise activity were beneficial for obese patients with persistent AF demonstrating the relevance of life-style management as an important adjunct to AF ablation in this setting.Trial registration numberNCT02064114.
Source: Europace - April 22, 2021 Category: Cardiology Source Type: research

BMI and BMI change following incident type 2 diabetes and risk of microvascular and macrovascular complications: the EPIC-Potsdam study
Conclusions/interpretationAmong people with incident type 2 diabetes, pre-diagnosis BMI was positively associated with microvascular complications, while a reduced risk was observed with weight loss when compared with stable weight. The relationships with macrovascular disease were less clear.Graphical abstract
Source: Diabetologia - March 8, 2021 Category: Endocrinology Source Type: research

Potential impact of gradual reduction of fat content in manufactured and out-of-home food on obesity in the United Kingdom: a modeling study
CONCLUSIONS: A modest fat reduction (particularly in SFA) in widely consumed foods would prevent obesity, type 2 diabetes, and cardiovascular disease.PMID:33677474 | DOI:10.1093/ajcn/nqaa396
Source: The American Journal of Clinical Nutrition - March 7, 2021 Category: Nutrition Authors: Roberta Alessandrini Feng J He Yuan Ma Vincenzo Scrutinio David S Wald Graham A MacGregor Source Type: research