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A Sugar Replacement May Be Linked to Heart Attacks and Strokes. Don ’ t Throw Out Your Stash Yet
Sugar replacements are everywhere in foods and beverages. But despite their ubiquity, the scientific verdict on whether or not they pose health risks ping pongs back and forth. Every so often, though, a study is published with a conclusion so shocking that it forces people to reassess their pantries. A Feb. 27 study published in the journal Nature Medicine now seems to have dealt such a blow to the sweetener erythritol, with data that suggest a connection between the ingredient and cardiovascular events such as clotting, stroke, and heart attacks.
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But before you clear your shel...
Source: TIME: Health - March 3, 2023 Category: Consumer Health News Authors: Haley Weiss Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news
Zero-calorie sweetener linked to heart attack, stroke, study finds
A sugar replacement used in many stevia, monk-fruit, keto and other reduced-sugar products marketed for weight loss and diabetes has been linked to stroke, heart attack and early death, a new study found.
Source: CNN.com - Health - February 28, 2023 Category: Consumer Health News Source Type: news
Zero calorie sweetener linked to heart attack, stroke, study finds
A sugar replacement used in many stevia, monk-fruit, keto and other reduced-sugar products marketed for weight loss and diabetes has been linked to stroke, heart attack and early death, a new study found.
Source: CNN.com - Health - February 27, 2023 Category: Consumer Health News Source Type: news
Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Mol Cell Biochem. 2023 Jan 7. doi: 10.1007/s11010-022-04653-4. Online ahead of print.ABSTRACTStroke cachexia is associated with prolonged inflammation, muscle loss, poor prognosis, and early death of stroke patients. No particular treatment is available to cure the symptoms or disease. The present study aimed to evaluate the effect of a 5-HT1a agonist, buspirone on stroke cachexia. Wistar rats were injected with endothelin-1 to the bregma region of the brain to induce ischemic stroke followed by induction of cachexia after 4 days. Treatment with buspirone (3 mg/kg p.o) was given for 4 weeks after confirmation of cachexia i...
Source: Molecular and Cellular Biochemistry - January 7, 2023 Category: Biochemistry Authors: Darshak Shah Mit Joshi Jigna Shah Bhoomika M Patel Source Type: research
Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke
AbstractDespite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDVLG3), a 21-kDa C-terminal subdomain of rhPDV, has been demonstrated to more avidly bind to the α2β1 integrin receptor than its parent molecule and consequently was postulated to evok...
Source: Translational Stroke Research - December 12, 2022 Category: Neurology Source Type: research
Preoperative risk model for perioperative stroke after intracranial tumor resection: ACS NSQIP analysis of 30,951 cases
CONCLUSIONS: The current study proposes a novel preoperative risk model for PCVA in patients undergoing ITR. Patients with poor physiological reserve (measured by frailty), multiple comorbidities, abnormal preoperative laboratory values, and those admitted under high acuity were at highest risk. The ITR-PCVA risk model may support patient-centered counseling striving to respect goals of care and maximize quality of life. Future prospective studies are warranted to validate the ITR-PCVA risk model and evaluate its utility as a bedside clinical tool.PMID:36455279 | DOI:10.3171/2022.9.FOCUS22402
Source: Neurosurgical Focus - December 1, 2022 Category: Neurosurgery Authors: Alexander J Kassicieh Kavelin Rumalla Syed Faraz Kazim Derek B Asserson Meic H Schmidt Christian A Bowers Source Type: research
Transitioning to GLP-1 RAs and SGLT2 Inhibitors as the First Choice for Managing Cardiometabolic Risk in Type 2 Diabetes
Abstract Purpose of ReviewThis forward-looking review summarizes existing evidence from cardiovascular outcome trials on cardiometabolic risk-reduction in type 2 diabetes (T2DM) management, with attention to updating and personalizing recommendations from recent diabetes practice guidelines issued by cardiology societies.Recent FindingsT2DM management has shifted towards cardiometabolic outcome improvement rather than purely glycemic control. According to large clinical trials, sodium-glucose cotransporter-2 inhibitors showed robust results in reducing heart failure (HF) hospitalization and chronic kidney disease (CKD) p...
Source: Current Atherosclerosis Reports - November 24, 2022 Category: Cardiology Source Type: research
How People With Diabetes Can Lower Stroke Risk
After spending nearly two decades trying to manage her Type 2 diabetes, Agnes Czuchlewski landed in the emergency room in 2015, with news that she’d just experienced a heart attack. She also learned that she had metabolic syndrome, a cluster of conditions that includes diabetes but also brings higher risk of heart disease and stroke.
“Because I needed to lose quite a bit of weight when I was first diagnosed, I was focused on the number I saw on the scale, and then on my blood-sugar numbers,” recalls Czuchlewski, 68, who lives in New York City. “I didn’t realize other numbers came into play, li...
Source: TIME: Health - November 10, 2022 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized Disease healthscienceclimate Source Type: news
NAFLD in Cardiovascular Diseases: A Contributor or Comorbidity?
In conclusion, a more comprehensive, multidisciplinary approach to diagnosis and management of patients with NAFLD and cardiovascular diseases is needed to optimize clinical outcomes. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Seminars in Liver Disease - October 14, 2022 Category: Gastroenterology Authors: Chen, Bing Tang, W.H Wilson Rodriguez, Mario Corey, Kathleen E. Sanyal, Arun J. Kamath, Patrick S. Bozkurt, Biykem Virk, Hafeez Ul Hassan Pressman, Gregg S. Lazarus, Jeffrey V. El-Serag, Hashem B. Krittanawong, Chayakrit Tags: Review Article Source Type: research
