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Weak UVB Irradiation Promotes Macrophage M2 Polarization and Stabilizes Atherosclerosis
AbstractAtherosclerosis (AS) is a chronic cardiovascular disease endangering human health and is one of the most common causes of myocardial infarction and stroke. Macrophage polarization plays a vital role in regulating plaque stability. As an important component of sunlight, ultraviolet B (UVB) has been proven to promote vitamin D and nitric oxide synthesis. This research used an AS model in ApoE−/− mice to study the effects of UVB on macrophage polarization and atherosclerotic plaque stability. In vitro, UVB irradiation increased arginase-I (Arg-I, M2 macrophage) and macrophage mannose receptor (CD206) expression, w...
Source: Journal of Cardiovascular Translational Research - November 22, 2021 Category: Cardiology Source Type: research

Calcifediol supplementation in adults on hemodialysis: a randomized controlled trial
CONCLUSIONS: In adults treated with hemodialysis and who had vitamin D insufficiency, calcifediol supplementation for 24 months had inconclusive effects on mortality and cardiovascular outcomes.TRIAL REGISTRATION NUMBER: NCT01457001.PMID:34173940 | DOI:10.1007/s40620-021-01104-z
Source: Journal of Nephrology - June 26, 2021 Category: Urology & Nephrology Authors: Luigi Morrone Suetonia C Palmer Valeria M Saglimbene Annalisa Perna Giuseppe Cianciolo Domenico Russo Loreto Gesualdo Patrizia Natale Antonio Santoro Sandro Mazzaferro Mario Cozzolino Adamasco Cupisti Marina Di Luca Biagio Di Iorio Giovanni F M Strippoli Source Type: research

Cardiovascular injuries during COVID-19 infection: A PROCESS-compliant case series from the Eastern Morocco
CONCLUSION: Cardiovascular involvement during COVID-19 should not be neglected and are associated with severe outcomes.PMID:33898022 | PMC:PMC8053362 | DOI:10.1016/j.amsu.2021.102309
Source: Annals of Medicine - April 26, 2021 Category: Internal Medicine Authors: Abdelilah El Rhalete Inas Rhazi Amine Bensaid Ikram Zaid Houssam Bkiyer Nabila Ismaili Nouha Elouafi Brahim Housni Source Type: research

Serum 25-hydroxyvitamin D, cardiovascular risk markers, and incident cardiovascular disease in a high risk community population
CONCLUSIONS: Vitamin D status likely offers no additional information on CVD risk over conventional laboratory-measured risk markers.PMID:33831385 | DOI:10.1016/j.clinbiochem.2021.04.001
Source: Clinical Biochemistry - April 8, 2021 Category: Biochemistry Authors: Jaeun Yang Yuan Dong Christopher T Naugler Lawrence de Koning Source Type: research

Fish, Cardiovascular Disease, and Mortality
Fish and shellfish (hereafter referred to as fish) are major sources of the dietary long-chain ω-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) and also contain other nutrients, such as vitamin D, riboflavin, iodine, calcium, phosphorus, magnesium, potassium, zinc, and iron. The summed results of observational studies of fish intake, randomized clinical tria ls of fish oil supplements, and associated mechanistic and experimental studies suggest that regular fish consumption may decrease the incidence of myocardial infarction (MI) and coronary heart disease (CHD), with more uncertain effec...
Source: JAMA Internal Medicine - March 8, 2021 Category: Internal Medicine Source Type: research

Study: Fish Oil Doesn ’ t Seem To Prevent Heart Problems
This study is consistent with earlier trials. The US Food and Drug Administration approved the fish oil-based drug Vascepa for heart attack and stroke prevention in 2019. Nissen hopes the FDA will take a look at these studies and reconsider that decision. “But it’s hard to get something undone once the genie gets out of the bottle,” he said. An editorial in the journal that accompanies the study written by Dr. Gregory Curfman, assistant professor of medicine at Harvard Medical School, also suggested the FDA should require a postmarketing clinical trial of a high-dose of fish oil, such as Vascepa, vs. corn...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 16, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Health Syndicated CBSN Boston CNN fish oil Source Type: news

Food rich in vitamin D such as cheese and oily fish is good for the heart, research shows
Lovers of cheese, eggs and oily fish are in luck, after Scientists discovered that the foods may protect against a heart attack or stroke, with the benefits being much more marked in men than women.
Source: the Mail online | Health - April 8, 2020 Category: Consumer Health News Source Type: news

Vitamin D and vascular disease.
Abstract Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Vitamin D deficiency has been identified as a potential risk factor for a number of diseases unrelated to the classical skeletal pathophysiology, such as cancer and CVD, but the effects of vitamin D supplementation are less clear. Purpose of this narrative review is to discuss the evidence suggesting an association between vitamin D status and CVD as well as the results of supplementation studies. Vitamin D deficiency has been associated with CVD risk factors such as hypertension, dyslipidemia and diabetes mellitus as well...
Source: Current Vascular Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Authors: Gouni-Berthold I, Berthold HK Tags: Curr Vasc Pharmacol Source Type: research

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