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Top 20 Research Studies of 2022 for Primary Care Physicians
This article summarizes the top 20 research studies of 2022 identified as POEMs (patient-oriented evidence that matters), excluding COVID-19. Statins for primary prevention of cardiovascular disease produce only a small absolute reduction in a person's likelihood of dying (0.6%), having a myocardial infarction (0.7%), or having a stroke (0.3%) over three to six years. Supplemental vitamin D does not reduce the risk of a fragility fracture, even in people with low baseline vitamin D levels or a previous fracture. Selective serotonin reuptake inhibitors are preferred medical therapy for panic disorder, and patients who disco...
Source: American Family Physician - April 13, 2023 Category: Primary Care Authors: Roland Grad Mark H Ebell Source Type: research

An Evidence-Based Review of Vitamin D for Common and High-Mortality Conditions
Conclusion: Prospective studies of vitamin D supplementation demonstrate variable impact on disease specific and patient-oriented outcomes, suggesting a correlation but not a causal relationship between low vitamin D levels and disease pathogenicity. Future research should determine dosing standards and timing of vitamin D in treatment and prevention.
Source: Journal of the American Board of Family Medicine - December 23, 2022 Category: Primary Care Authors: Michael, W., Couture, A. D., Swedlund, M., Hampton, A., Eglash, A., Schrager, S. Tags: Clinical Review Source Type: research

Inflammation-mediated vitamin K and vitamin D effects on vascular calcifications in people with HIV on active antiretroviral therapy
Background: People with HIV (PWH) experience increased systemic inflammation and monocyte activation, leading to increased risk of cardiovascular events (death, stroke, and myocardial infarction) and higher coronary artery calcium scores (CACs). Vitamins D and K2 have significant anti-inflammatory effects; in addition, vitamin K2 is involved in preventing vascular calcifications in the general population. The roles of vitamins D and K in increased coronary calcifications in successfully treated PWH is less understood. Methods: We prospectively recruited 237 PWH on antiretroviral treatment (ART) and 67 healthy co...
Source: AIDS - March 25, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control
ConclusionsGenetically predicted increase in Vit-D status [25(OH)D] may confer secondary protection against incident combined CVD events and myocardial infarction in a hypertensive-diabetic population where serological 25(OH)D deficiency is common, through facilitating blood pressure control.
Source: Genes and Nutrition - January 29, 2022 Category: Nutrition Source Type: research

Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial-a randomized controlled trial
CONCLUSIONS: Vitamin D3 supplementation did not lower the incidence of major CVD events or invasive cancer among older adults, possibly due to sufficient vitamin D status in most participants at baseline. Clinical Trial Registry number: ClinicalTrials.gov: NCT01463813, https://clinicaltrials.gov/ct2/show/NCT01463813.PMID:34982819 | DOI:10.1093/ajcn/nqab419
Source: The American Journal of Clinical Nutrition - January 4, 2022 Category: Nutrition Authors: Jyrki K Virtanen Tarja Nurmi Antti Aro Elizabeth R Bertone-Johnson Elina Hypp önen Heikki Kr öger Christel Lamberg-Allardt JoAnn E Manson Jaakko Mursu Pekka M äntyselkä Sakari Suominen Matti Uusitupa Ari Voutilainen Tomi-Pekka Tuomainen Sari Hantunen Source Type: research

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