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The impact of plasma vitamin C levels on the risk of cardiovascular diseases and Alzheimer's disease: a Mendelian randomization study
Previous observational studies have reported associations between plasma vitamin C levels, and cardiovascular diseases (CVDs) and Alzheimer's disease (AD); however, no conclusive results have been obtained. We conducted a Mendelian randomization (MR) study to investigate the causality of vitamin C on the risk of nine CVDs [including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), heart failure (HF), stroke, ischemic stroke (IS), and IS subtypes] and Alzheimer's disease.
Source: Clinical Nutrition - September 4, 2021 Category: Nutrition Authors: Lu Chen, Xingang Sun, Zhen Wang, Yunlong Lu, Miao Chen, Yuxian He, Hongfei Xu, Liangrong Zheng Tags: Original article Source Type: research

Cardiovascular injuries during COVID-19 infection: A PROCESS-compliant case series from the Eastern Morocco
CONCLUSION: Cardiovascular involvement during COVID-19 should not be neglected and are associated with severe outcomes.PMID:33898022 | PMC:PMC8053362 | DOI:10.1016/j.amsu.2021.102309
Source: Annals of Medicine - April 26, 2021 Category: Internal Medicine Authors: Abdelilah El Rhalete Inas Rhazi Amine Bensaid Ikram Zaid Houssam Bkiyer Nabila Ismaili Nouha Elouafi Brahim Housni Source Type: research

Vitamin C: historical perspectives and heart failure
AbstractVitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes. It has received much attention due to its ability in limiting reactive oxygen species, oxidative stress, and nitrosative stress, as well as it helps to maintain some of the normal metabolic functions of the cell. However, over 140 clinical trials using Vit C in different pathological conditions such as myocardial infarction, gastritis, diabetes, hypertension, stroke, and cancer have yielded inconsistent results....
Source: Heart Failure Reviews - October 8, 2020 Category: Cardiology Source Type: research

Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
The objective of this study is to explore the current literature supporting the use oral multivitamins and multi/minerals (OMVMs) for cardiovascular diseases (CVD) treatment and prevention.Recent FindingsData on multivitamins, vitamin C and D, coenzyme Q, calcium, and selenium, has showed no consistent benefit for the prevention of CVD, myocardial infarction, or stroke, nor was there a benefit for all-cause mortality to support their routine supplementation. Folic acid alone and B vitamins with folic acid, B6 and B12, reduce stroke, whereas niacin and antioxidants are associated with an increased risk of all-cause mortalit...
Source: Current Cardiology Reports - February 13, 2020 Category: Cardiology Source Type: research

The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature
Publication date: Available online 7 November 2019Source: Food Research InternationalAuthor(s): Samad Ghaffari, Neda RoshanravanAbstractHypertension (HTN) is a worldwide epidemic in both developed and developing countries. It is one of the leading causes of major health problems such as cardiovascular disease, stroke, and heart attack. In recent years, several studies have reported associations between specific dietary ingredients and improving HTN. Nutraceuticals are natural food components with pharmacological properties. Reports suggest that functional foods and nutraceutical ingredients might support patients to obtain...
Source: Food Research International - November 8, 2019 Category: Food Science Source Type: research

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Associations between Ambient Fine Particulate Oxidative Potential and Cardiorespiratory Emergency Department Visits
Conclusions: Lag 0–2 OPDTT was associated with ED visits for multiple cardiorespiratory outcomes, providing support for the utility of OPDTT as a measure of fine particle toxicity. https://doi.org/10.1289/EHP1545 Received: 23 December 2016 Revised: 4 August 2017 Accepted: 12 August 2017 Published: 26 October 2017 Please address correspondence to J.Y. Abrams, Centers for Disease Control and Prevention, NCEZID/DHCPP, 1600 Clifton Rd. NE, CDC Mailstop A30, Atlanta, GA 30333 USA. Telephone: (404) 639-5121. Email: jabrams@cdc.gov Supplemental Material is available online (https://doi.org/10.1289/EHP1545). The authors ...
Source: EHP Research - October 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research