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Elevated fibrinogen and lowered homocysteine-vitamin determinants and their association with left atrial thrombus in patients with rheumatic mitral stenosis.
In this study, fibrinogen, vitamin B12 and folate were independently associated with the occurrence of thrombus in patients with rheumatic MS. Hence, our results suggest that increase in procoagulant mechanisms contribute to increased risk of thrombosis in the left atrium in patients with rheumatic MS. PMID: 26510264 [PubMed - indexed for MEDLINE]
Source: British Journal of Biomedical Science - December 2, 2015 Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke
The purpose of this narrative review is to highlight insights into the importance and frequency of metabolic vitamin B12 (B12) deficiency, reasons why it is commonly missed, and reasons for the widespread but mistaken belief that treatment of B12 deficiency does not prevent stroke or improve cognitive function. Metabolic B12 deficiency is common, being present in 10%-40% of the population; is frequently missed; is easily treated; and contributes importantly to cognitive decline and stroke in older people.
Source: Nutrition Research - October 21, 2015 Category: Nutrition Authors: J. David Spence Tags: Review Article Source Type: research

Metabolic B12 deficiency: a missed opportunity to prevent dementia and stroke
The purpose of this narrative review is to highlight insights into the importance and frequency of metabolic vitamin B12 (B12) deficiency, reasons why it commonly missed, and reasons for the widespread but mistaken belief that treatment of B12 deficiency does not prevent stroke or improve cognitive function. Metabolic B12 deficiency is common, being present in 10-40% of the population, frequently missed, easily treated and contributes importantly to cognitive decline and stroke in older people. Measuring serum B12 alone is not sufficient for diagnosis; it is necessary to measure holotranscobalamin or functional markers of ...
Source: Nutrition Research - October 21, 2015 Category: Nutrition Authors: J. David Spence Source Type: research

Supplements That Save Lives And Bucks
I’m sure I don’t have to tell you about the high cost of medical care these days. The fact is that as costs continue to skyrocket, more and more Americans are driven into bankruptcy, because they cannot pay their medical bills. Too often, they even lose their homes. You may have even lost a neighbor to this disturbing trend. It may have even happened to you – although, I certainly hope not. That’s one reason I have always dedicated myself to keeping my patients out of hospitals – which often see patients as cash cows, instead of human beings. And a cornerstone of this philosophy has been based upon pr...
Source: Al Sears, MD Natural Remedies - June 3, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Nutrition supplements vitamins Source Type: news

Is Vitamin B12 Deficiency a Risk Factor for Cardiovascular Disease in Vegetarians?
Publication date: June 2015 Source:American Journal of Preventive Medicine, Volume 48, Issue 6 Author(s): Roman Pawlak The goal of this paper is to describe the role of vitamin B12 deficiency in cardiovascular disease development among vegetarians. Vegetarians have a high prevalence of vitamin B12 deficiency. Deficiency of this vitamin is associated with a variety of atherogenic processes that are mainly, but not exclusively, due to vitamin B12 deficiency–induced hyperhomocysteinemia. Each 5-μmol/L increase above 10 μmol/L of serum homocysteine is associated with a 20% increased risk of circulatory health problems. M...
Source: American Journal of Preventive Medicine - May 23, 2015 Category: Global & Universal Source Type: research

Effects of differences in serum total homocysteine, folate, and vitamin B 12 on cognitive impairment in stroke patients
Conclusion: The tHcy levels were significantly higher and the vitamin B12 and folate levels were significantly lower in the patients with VCIND than those in the other groups. The high tHcy levels in the VCIND patients may be correlated with impaired cognitive function.
Source: BMC Neurology - November 30, 2014 Category: Neurology Authors: Bo JiangYumei ChenGuoen YaoCunshan YaoHongmei ZhaoXiangdong JiaYunyan ZhangJunling GeEnchao QiuChengyun Ding Source Type: research

Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis
Conclusions: B vitamin supplementation for homocysteine reduction significantly reduced stroke events, especially in subjects with certain characteristics who received appropriate intervention measures.
Source: Neurology - October 7, 2013 Category: Neurology Authors: Ji, Y., Tan, S., Xu, Y., Chandra, A., Shi, C., Song, B., Qin, J., Gao, Y. Tags: Stroke prevention, Nutritional, All Cerebrovascular disease/Stroke, Clinical trials Systematic review/meta analysis, Class II ARTICLE Source Type: research

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin.
CONCLUSIONSMetformin use was associated with impaired cognitive performance. Vitamin B12 and calcium supplements may alleviate metformin-induced vitamin B12 deficiency and were associated with better cognitive outcomes. Prospective trials are warranted to assess the beneficial effects of vitamin B12 and calcium use on cognition in older people with diabetes who are taking metformin. PMID: 24009301 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 5, 2013 Category: Endocrinology Authors: Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H, Woodward M, Boundy K, Ellis KA, Bush AI, Faux NG, Martins R, Szoeke C, Rowe C, Watters DA, the AIBL Investigators Tags: Diabetes Care Source Type: research

Effect of B Vitamins and Lowering Homocysteine on Cognitive Impairment in Patients With Previous Stroke or Transient Ischemic Attack: A Prespecified Secondary Analysis of a Randomized, Placebo-Controlled Trial and Meta-Analysis Clinical Sciences
Conclusions— Daily supplementation with folic acid, vitamin B6, and vitamin B12 to a self-selected clinical trial cohort of cognitively unimpaired patients with previous stroke or transient ischemic attack lowered mean tHcy but had no effect on the incidence of cognitive impairment or cognitive decline, as measured by the MMSE, during a median of 2.8 years. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN74743444; URL: http://www.clinicaltrials.gov. Unique identifier: NCT00097669.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Hankey, G. J., Ford, A. H., Yi, Q., Eikelboom, J. W., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., Schmidt, R., Almeida, O. P., van Bockxmeer, F. M., on Behalf of the VITATOPS Trial Study Group Tags: Other Treatment, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Neurology: Images in Clinical Medicine
Editor: V. Dimov, M.D., Cleveland ClinicHypoglossal Nerve Palsy during Meningococcal Meningitis. NEJM, 10/2014.Absent Superficial Abdominal Reflex due to thoracic spinal cord neuromyelitis. NEJM, 05/2014.Kayser-Fleischer Rings in Wilson ' s Disease. NEJM, 03/2012.Perilymph Fistula Test leads to nystagmus. NEJM, 01/2012.A stray bullet in the brain - with no deficit of power, cognition, sense of touch, or speech. Lancet, 01/2012.Blindness after Fat Injections. NEJM, 12/2011.Internal-Carotid-Artery Dissection and Cranial-Nerve Palsies. NEJM, 12/2011.A Head Shot. NEJM, 12/2011.Multiple Intracranial Tuberculomas. NEJM, 10/2011....
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Images Neurology Source Type: news

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