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Total 29 results found since Jan 2013.

Janssen Submits Application to U.S. FDA for New Indication to Expand Use of XARELTO ® (rivaroxaban) in Patients with Peripheral Artery Disease
RARITAN, NJ, October 26, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for a new indication to expand the use of XARELTO® (rivaroxaban) in patients with peripheral artery disease (PAD). If approved, this new indication for the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 75-100 mg once daily) would include reducing the risk of major thrombotic vascular events such as heart attack, stroke and amputation in patients after recent lower-extremity revascularization, a c...
Source: Johnson and Johnson - October 26, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Automatic Grading of Retinal Blood Vessel in Deep Retinal Image Diagnosis
AbstractAutomatic grading of retinal blood vessels from fundus image can be a useful tool for diagnosis, planning and treatment of eye. Automatic diagnosis of retinal images for early detection of glaucoma, stroke, and blindness is emerging in intelligent health care system. The method primarily depends on various abnormal signs, such as area of hard exudates, area of blood vessels, bifurcation points, texture, and entropies. The development of an automated screening system based on vessel width, tortuosity, and vessel branching are also used for grading. However, the automated method that directly can come to a decision b...
Source: Journal of Medical Systems - August 31, 2020 Category: Information Technology Source Type: research

Retinal Vascular Signs and Cerebrovascular Diseases
Conclusions: There is extensive and increasing evidence that a range of retinal vascular signs and disease are closely linked to CeVD, including subclinical and clinical CeVD. New technology including AI-DL will allow further translation to clinical utilization.
Source: Journal of Neuro-Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Disease of the Year: Cerebrovascular Disorders Source Type: research

Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral ischemia in mice
Publication date: Available online 23 January 2020Source: PeptidesAuthor(s): Keita Sasaki, Sebok Kumar Halder, Hayato Matsunaga, Hiroshi UedaAbstractProthymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits cerebral or retinal ischemia-induced behavioral, electrophysiological and histological damage. P6Q also abolishes cerebral hemorrhage induced by ischemia with tissue plasminogen activator (tPA). In the present study we examined the beneficial effects of P6Q on other post-stroke prognostic psychology-related symptoms, which obstruct the motivation toward physical therapy. Intravenous (i.v.) admini...
Source: Peptides - January 24, 2020 Category: Biochemistry Source Type: research

Retinal vessel changes in cerebrovascular disease
Purpose of review The retina is growingly recognized as a window into cerebrovascular and systemic vascular conditions. The utility of noninvasive retinal vessel biomarkers in cerebrovascular risk assessment has expanded due to advances in retinal imaging techniques and machine learning-based digital analysis. The purpose of this review is to underscore the latest evidence linking retinal vascular abnormalities with stroke and vascular-related cognitive disorders; to highlight modern developments in retinal vascular imaging modalities and software-based vasculopathy quantification. Recent findings Longitudinal studies...
Source: Current Opinion in Neurology - January 17, 2020 Category: Neurology Tags: NEURO-OPHTHALMOLOGY: Edited by Heather E. Moss Source Type: research

What Causes Facial Nerve Palsy?
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - June 3, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. The relationship between NTFs and glia is crucial for both the developing and adult brain. While some of these factors, such as NT-3 and CNTF, have highly potent effects on gliogenesis, others like BDNF and GDNF, are important for glia-mediated synapse formation. Neurotrophic factors play significant roles during neurodegenerative disorders. In many cases, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs
Conclusion The use of optical non-invasive diagnostic methods has a great potential for the detection of concomitant microcirculation disorders in patients with rheumatic diseases and diabetes. In this review, it was shown that the use of laser Doppler flowmetry, optical tissue oximetry and fluorescence spectroscopy together or separately may have important diagnostic value for the detection of violations, assessment of their severity, as well as for the analysis of the effectiveness of the therapy. The joint application of the considered technologies with the methods of machine learning (discriminant analysis) can be use...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzhe...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Are Eggs Healthy? Here ’s What the Experts Say
Eggs dominate the menus of all sorts of breakfast spots, from fast-food chains to organic cafes. But the humble egg comes with a lot of questions: Will eggs raise your cholesterol? Should you order an egg-white omelet or embrace the yolks? And what about organic eggs — are they really more nutritious? Whether you eat them every day or just occasionally, there’s plenty to learn about how to incorporate eggs into a healthy diet. Here, dietitians weigh in on what you need to know about nutrition in eggs. Are eggs healthy? Nutrition experts agree that the protein and vitamins in eggs make them a healthy option. &ld...
Source: TIME: Health - December 5, 2018 Category: Consumer Health News Authors: Cassie Shortsleeve  Tags: Uncategorized Diet/Nutrition Source Type: news

Are Eggs Healthy? Here ’s What Experts Say
Eggs dominate the menus of all sorts of breakfast spots, from fast-food chains to organic cafes. But the humble egg comes with a lot of questions: Will eggs raise your cholesterol? Should you order an egg-white omelet or embrace the yolks? And what about organic eggs — are they really more nutritious? Whether you eat them every day or just occasionally, there’s plenty to learn about how to incorporate eggs into a healthy diet. Here, dietitians weigh in on what you need to know about nutrition in eggs. Are eggs healthy? Nutrition experts agree that the protein and vitamins in eggs make them a healthy option. &ld...
Source: TIME: Health - December 5, 2018 Category: Consumer Health News Authors: Cassie Shortsleeve  Tags: Uncategorized Diet/Nutrition Source Type: news

Not as Simple as Canker Sores
BY ​NANA P. MATSUMOTO, & DEREK MEEKS, DO​​A 16-year-old boy presented to a rural ED with a swollen jaw, painful blisters in the mouth, and earache for the past day. One week before, he had a fever with chills, sore throat, and dry coughs. He was not taking any medications, and his immunizations were up-to-date. He had a mild learning disorder but no significant past medical or surgical history.​An apthous ulcer, the most common and one of the earliest signs of Behçet's disease.The patient's vital signs were within normal limits, and his physical examination revealed anterior cervical lymphadenopathy, sinus con...
Source: The Case Files - October 11, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research