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Quantification of retinal ganglion cell loss in patients with homonymous visual field defect due to stroke
ConclusionsReduction of SD-OCT parameters occurs following both ischaemic and haemorrhagic occipital stroke, but it is larger when the injury extends to parietal territories and increases as time since stroke increases. The size of visual field defect is unrelated to SD-OCT measurements. Macular GCC thinning appeared to be more sensitive than pRNFL in detecting retrograde retinal ganglion cell degeneration and its retinotopic pattern in stroke.
Source: Neurological Sciences - March 11, 2023 Category: Neurology Source Type: research

Activation of HIF-1α/VEGF-A pathway by deferoxamine ameliorates retinal hypoxia in a rat subarachnoid hemorrhage model
Conclusions Our findings suggest that modulating the application of deferoxamine may offer therapeutic approaches to alleviate retinal complications after SAH.
Source: NeuroReport - October 6, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research

Effects of remote ischemic conditioning on sleep complaints in Parkinson's disease –rationale, design, and protocol for a randomized controlled study
ConclusionThis study is a prospective randomized controlled trial to determine the safety, feasibility, and potential efficacy of RIC for patients with Parkinson's disease associated with EDS.
Source: Frontiers in Neurology - July 25, 2022 Category: Neurology Source Type: research

Retinal parameters, cortical cerebral microinfarcts and their interaction with cognitive impairment
Conclusions: Retinal vascular and neuronal parameters are associated with cortical CMIs and persons with both pathologies are likely to have cognitive impairment. Further studies may be warranted to evaluate the clinical utility of retinal parameters and CMI in risk prediction for cognitive dysfunction.Data access statement: The data that support the findings of this study is available from the corresponding author upon request.PMID:35450485 | DOI:10.1177/17474930221097737
Source: Atherosclerosis - April 22, 2022 Category: Cardiology Authors: Saima Hilal Carol Y Cheung Tien Yin Wong Leopold Schmetterer Christopher Chen Source Type: research

Homonymous visual field defect and retinal thinning after occipital stroke
ConclusionGCIPL and RNFL thinning were observed in the patients with VFD. GCIPL thinning appears in two forms: atypical diffuse thinning, or homonymous hemi-GCIPL thinning. Examining GCIPL and RNFL provides easy and reliable objective measures and is therefore proposed to be of predictive value on visual function.
Source: Brain and Behavior - September 6, 2021 Category: Neurology Authors: Avan Sabir Rashid, Darian Rashid, Ge Yang, Hans Link, Helena Gauffin, Yumin Huang ‐Link Tags: ORIGINAL ARTICLE Source Type: research

Remote Ischemic Post-Conditioning Therapy is Protective in Mouse Model of Traumatic Optic Neuropathy
AbstractTraumatic optic neuropathy (TON) is characterized by visual dysfunction after indirect or direct injury to the optic nerve following blunt head trauma. TON is associated with increased oxidative stress and inflammation resulting in retinal ganglion cell (RGC) death. Remote ischemic post-conditioning (RIC) has been shown to enhance endogenous protective mechanisms in diverse disease models including stroke, vascular cognitive impairment (VCI), retinal injury and optic nerve injury. However, the protective mechanisms underlying the improvement of retinal function and RGC survival after RIC treatment remain unclear. H...
Source: NeuroMolecular Medicine - September 1, 2021 Category: Neurology Source Type: research

Immuno-histological detection of resistant columnar units and vulnerable networks in the rat retina after asphyxia-induced transient cardiac arrest
CONCLUSIONS: Regardless of the many defects, the surviving neuronal structures seemed to be able to maintain retinal functionality, which can be additionally improved by regenerative processes true to the "use it or lose it" dogma.PMID:34334436 | DOI:10.3233/RNN-211174
Source: Restorative Neurology and Neuroscience - August 2, 2021 Category: Neurology Authors: Gerburg Keilhoff Maximilian Titze Uwe Ebmeyer Source Type: research

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