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Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Consumption of flavonoid-rich fruits, flavonoids from fruits, and stroke risk: a prospective cohort study.
Abstract We sought to examine the prospective associations of specific fruit consumption, in particular flavonoid-rich fruit (FRF) consumption, with the risk of stroke and subtypes of stroke in a Japanese population. A study followed a total of 39,843 men and 47,334 women aged 44-76 years, and free of cardiovascular disease, diabetes, and cancer at baseline since 1995 and 1998 to the end of 2009 and 2012, respectively. Data on total and specific FRF consumption for each participant were obtained using a self-administrated food frequency questionnaire. The hazard ratios (HRs) of stroke in relation to total and spec...
Source: The British Journal of Nutrition - January 29, 2021 Category: Nutrition Authors: Gao Q, Dong JY, Cui R, Muraki I, Yamagishi K, Sawada N, Iso H, Tsugane S, Japan Public Health Center-based Prospective Study Group Tags: Br J Nutr Source Type: research

High consumption of dairy products and risk of major adverse coronary events and stroke in a Swedish population
Br J Nutr. 2023 Sep 6:1-28. doi: 10.1017/S0007114523001939. Online ahead of print.ABSTRACTThe association between consumption of dairy products and risk of cardiovascular diseases (CVD) has been inconsistent. There is a lack of studies in populations with high intakes of dairy products. We aimed to examine the association between intake of dairy products and risk of incident major adverse coronary events and stroke in the Swedish Malmö Diet and Cancer cohort study. We included 26,190 participants without prevalent CVD or diabetes. Dietary habits were obtained from a modified diet history and endpoint data were extracted f...
Source: The British Journal of Nutrition - September 6, 2023 Category: Nutrition Authors: Justine Dukuzimana Suzanne Janzi Caroline Habberstad Shunming Zhang Yan Born é Emily Sonestedt Source Type: research

Napping Once Or Twice A Week Could Lower Heart Attack & Stroke Risk, Study Finds
By Amy Woodyatt, CNN (CNN) — Some good news for nap fanatics — a new study has found that a daytime nap taken once or twice a week could lower the risk of heart attacks or strokes. Researchers from the University Hospital of Lausanne, Switzerland studied the association between napping frequency and duration and the risk of fatal and non-fatal cardiovascular disease complications. Tracking 3,462 people between the ages of 35 and 75 for just over five years, the report authors found that those who indulged in occasional napping — once or twice a week, for between five minutes to an hour — were 48% ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 10, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston CNN Heart Attack Stroke Source Type: news

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Long-term Fine Particulate Matter Exposure and Nonaccidental and Cause-specific Mortality in a Large National Cohort of Chinese Men
Conclusions: Long-term exposure to PM2.5 was associated with nonaccidental, CVD, lung cancer, and COPD mortality in China. The IER estimator may underestimate the excess relative risk of cause-specific mortality due to long-term exposure to PM2.5 over the exposure range experienced in China and other low- and middle-income countries. https://doi.org/10.1289/EHP1673 Received: 24 February 2017 Revised: 01 September 2017 Accepted: 05 September 2017 Published: 07 November 2017 Address correspondence to M. Zhou, National Center for Chronic Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control ...
Source: EHP Research - November 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

FDA Approves Two New Indications for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, Dec. 20, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved two pediatric indications for XARELTO® (rivaroxaban): the treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients from birth to less than 18 years after at least five days of initial parenteral (injected or intravenous) anticoagulant treatment; and thromboprophylaxis (prevention of blood clots and blood-clot related events) in children aged two years and older with congenital heart disease who have...
Source: Johnson and Johnson - December 21, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Following UK dietary advice may cut heart disease risk
Conclusion This study showed that following dietary recommendations closely for 12 weeks can reduce blood pressure by a significant amount, which is likely to cut the chances of having a heart attack or stroke for an average healthy middle-aged person. The diet also affects cholesterol levels, but the overall effect of this may be modest. The study appears to have been carefully conducted to avoid biasing the results. The researchers gave butter or margarine spread and cooking oil to people in both groups, for example, and asked everyone to fill out food diaries, as well as taking urine samples for nutrient analysis. Thi...
Source: NHS News Feed - March 19, 2015 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Association of an evolutionary-concordance lifestyle pattern score with cardiovascular disease incidence among Black and White men and women
Br J Nutr. 2022 Aug 9:1-28. doi: 10.1017/S0007114522002549. Online ahead of print.ABSTRACTDietary and lifestyle evolutionary discordance is hypothesized to play a role in the etiology of cardiovascular disease (CVD), including coronary heart disease (CHD), and stroke. We aimed to investigate associations of a previously-reported, total (dietary plus lifestyle) evolutionary-concordance (EC) pattern score with incident CVD, CHD, and stroke. We used multivariable Cox proportional hazards regression to investigate associations of the EC score with CVD, CHD, and stroke incidence among United States Black and White men and women...
Source: The British Journal of Nutrition - August 9, 2022 Category: Nutrition Authors: Ziling Mao Alyssa N Troeschel Suzanne Judd James M Shikany Emily B Levitan Monika M Safford Roberd M Bostick Source Type: research

One in 10 men aged 50 'have the heart of a 60-year-old'
"One-tenth of 50-year-old men have a heart age 10 years older than they are," BBC News reports. This is the finding of an analysis of 1.2 million people who used the NHS Heart Age Test. The principle behind the test is that you can "age" your heart through unhealthy behaviour such as smoking and being obese. Underlying conditions like high blood pressure and high cholesterol, which often have no noticeable symptoms, can also age the heart. An obese smoker in their 50s who has high blood pressure and high cholesterol could have the heart of a 60- or 70-year-old. The quick and simple test tells you the...
Source: NHS News Feed - September 4, 2017 Category: Consumer Health News Tags: Heart/lungs Source Type: news

Neuromuscular and Muscle Metabolic Functions in MELAS Before and After Resistance Training: A Case Study
Conclusion To conclude, this study suggests a preserved plasticity in the skeletal muscle of a patient with MELAS. More importantly, Resistance Training appears to be a safe and effective method to increase skeletal muscle function in this patient population, and this effect is mediated by both neuromuscular and mitochondrial adaptations. However, particular attention and caution is needed in the interpretation of the data of this single case study and further studies are warranted including larger sample of patients. Ethics Statement For this case study the participant caregiver provided written informed consent. Auth...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Correlates of a southern diet pattern in a national cohort study of blacks and whites: the REGARDS study
CONCLUSION: There was a high consumption of the Southern dietary pattern in the US black population, regardless of other factors, underlying our previous findings showing the substantial contribution of this dietary pattern to racial disparities in incident hypertension and stroke.PMID:33632366 | DOI:10.1017/S0007114521000696
Source: The British Journal of Nutrition - February 26, 2021 Category: Nutrition Authors: Catharine A Couch Marquita S Brooks James M Shikany Virginia J Howard George Howard D Leann Long Leslie A McClure Jennifer J Manly Mary Cushman Neil A Zakai Keith E Pearson Emily B Levitan Suzanne E Judd Source Type: research

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