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Association of chocolate consumption with neurological and cardiovascular outcomes in atrial fibrillation: data from two Swiss atrial fibrillation cohort studies (Swiss-AF and BEAT-AF)
CONCLUSION: While chocolate consumption was not associated with MRI findings and major adverse cardiac events in an atrial fibrillation population, No/Low-Ch was associated with a lower cognitive construct score, higher risk of heart failure hospitalisation and increased all-cause mortality compared to Mod-Ch.CLINICALTRIALS: gov Identifier: NCT02105844.PMID:37609948 | DOI:10.57187/smw.2023.40109
Source: Swiss Medical Weekly - August 23, 2023 Category: General Medicine Authors: Annina Stauber Andreas M üller Nikki Rommers Stefanie Aeschbacher Nicolas Rodondi Leo H Bonati Juerg H Beer Raban V Jeger David J Kurz Claudia Liedtke Peter Ammann Marcello Di Valentino Patricia Chocano Richard Kobza Michael K ühne David Conen Stefan Os Source Type: research

Eating dark chocolate could protect the brain from stroke, says doctor
One study revealed the sweet treat contains a compound that can help shield nerve cells from damage.
Source: Daily Express - Health - June 16, 2023 Category: Consumer Health News Source Type: news

Study finds risk of stroke can rise by 10 per cent by having extra daily bar of chocolate
'Free sugar' has been linked to an increased risk of cardiovascular disease in a study of more than 110,000 people in the UK, whose health was tracked for nine years on average.
Source: the Mail online | Health - February 14, 2023 Category: Consumer Health News Source Type: news

9 Ways to Squeeze in More Steps Every Day
Every day for the past decade, I’ve tried to dethrone the family walking champ: my 67-year-old dad. Despite my youthful advantage—he has more than 30 years on me, as he’s quick to point out—I haven’t logged more steps than him once. I find this to be both mortifying and a point of vicarious pride; his fitness is remarkable. It’s also excellent motivation to find creative ways to finally out-walk him. My dad and I compete using our favorite pedometer app, which displays each day’s steps in a bar graph. (While we both wear Apple Watches, we like the app best for logging the entire da...
Source: TIME: Health - January 12, 2023 Category: Consumer Health News Authors: Angela Haupt Tags: Uncategorized Exercise & Fitness healthscienceclimate Source Type: news

How Menopause Affects Cholesterol —And How to Manage It
Kelly Officer, 49, eats a vegan diet and shuns most processed foods. So, after a recent routine blood test revealed that she had high cholesterol, “I was shocked and upset,” she says, “since it never has been [high] in the past.” Officer is not alone. As women enter menopause, cholestrol levels jump—by an average of 10-15%, or about 10 to 20 milligrams per deciliter. (A healthy adult cholesterol range is 125-200 milligrams per deciliter, according to the National Library of Medicine.) This change often goes unnoticed amidst physical symptoms and the general busyness of those years. But, says D...
Source: TIME: Health - September 21, 2022 Category: Consumer Health News Authors: Katherine Harmon Courage Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news

Predictive role of modifiable factors in stroke: an umbrella review
Discussion Diet with rich macronutrients and micronutrients, healthy dietary patterns and favourable physical, emotional health and environmental management should be promoted to decrease the burden of stroke. PROSPERO registration number CRD42021249921.
Source: BMJ Open - June 16, 2022 Category: General Medicine Authors: Wang, X., Liang, M., Zeng, F., Wang, Y., Yang, Y., Nie, F., Shang, M., Ta, N., Wen, L., Ou, L., Yang, Z., Liu, W. Tags: Open access, Neurology Source Type: research

Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model
In this study, neuroprotective potential of theobromine (TBR) was evaluated in 2-vessel occlusion transient global cerebral ischemia-reperfusion (tGCI/R) rat model. Rats were treated with TBR (50, 100 mg/kg, p.o.) for 7 successive days, and subjected to bilateral common carotid artery occlusion (20 min) or sham surgery after last dose of TBR. Severe neurological deficits accompanied by brain infarction, blood-brain barrier abnormalities, and oedema were noted in rats subjected to tGCI/R, and these effects were prevented by TBR. TBR protected against lipid peroxidation and enhanced glutathione level in brain against tGCI/R....
Source: Biochemical and Biophysical Research communications - July 25, 2021 Category: Biochemistry Authors: Javeed Ahmad Bhat Sushma Gupta Manish Kumar Source Type: research

A Comparison of Three Different Bioinformatics Analyses of the 16S –23S rRNA Encoding Region for Bacterial Identification
Conclusion The higher resolution at the species level identification provided by 16S–23S rRNA encoding region NGS makes its use in routine diagnostic microbiology potentially attractive. Particularly, data analysis is one of the most important steps of a diagnostic workflow, which requires an optimal pipeline for the interpretation of the sequencing data in a short time. This study demonstrates that de novo assembly and subsequent BLASTN analysis using an in-house developed database compared to OTU clustering and mapping approaches is the most accurate and fastest approach for identification of bacterial pathogens....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Chocolate and risk of chronic disease: a systematic review and dose-response meta-analysis
ConclusionChocolate consumption is not related to risk for several chronic diseases, but could have a small inverse association with CHD and stroke. Our findings are limited by very low  or low credibility of evidence, highlighting important uncertainty for chocolate–disease associations.
Source: European Journal of Nutrition - February 25, 2019 Category: Nutrition Source Type: research

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