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Infectious Disease: Parasitic Diseases

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Total 75 results found since Jan 2013.

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research

A parasitic type piezoelectric actuator with the asymmetrical trapezoid flexure mechanism
This study shows a meaningful idea of the utilization of the asymmetrical trapezoid flexure mechanism for the design of novel piezoelectric actuators.Graphical Abstract
Source: Sensors and Actuators A: Physical - February 19, 2020 Category: Physics Source Type: research

Neurocognitive sequelae following hippocampal and callosal lesions associated with cerebral malaria in an immune-naive adult
We report a case of a 36-year-old immune-naive Caucasian female who sustained a brain injury with neurocognitive sequelae, after a severe bout of falciparum malaria. On admission, she was unconscious, febrile, hypoglycaemic and passing black urine. She had returned from Ghana 2 days earlier. Her initial parasite count was 22%,...
Source: Postgraduate Medical Journal - October 15, 2013 Category: Journals (General) Authors: Laverse, E., Nashef, L., Brown, S. Tags: Immunology (including allergy), Drugs: infectious diseases, Travel medicine, Tropical medicine (infectious diseases), Epilepsy and seizures, Stroke, Memory disorders (psychiatry), Adult intensive care, Epidemiology, Diabetes, Metabolic disorders Images Source Type: research

Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
Conclusions: This study suggests that NRG-1 attenuates ECM-associated brain inflammation and injuries and may represent a novel supportive therapy for the management of CM.
Source: Epidemiologic Perspectives and Innovations - January 17, 2014 Category: Epidemiology Authors: Wesley SolomonNana O WilsonLeonard AndersonSidney PittsJohn PatricksonMingli LiuByron D FordJonathan K Stiles Source Type: research

Pacific and Atlantic Lepeophtheirus salmonis (Krlatin small letter o with strokeyer, 1838) are allopatric subspecies: Lepeophtheirus salmonis salmonis and L. salmonis oncorhynchi subspecies novo
Conclusions: Lepeophtheirus salmonis from the Pacific and Atlantic oceans are reproductively compatible at least until adults at the F2 hybrid stage, and should not be regarded as separate species based on reproductive segregation or sequence divergence levels. Reported biological and genetic differences in L. salmonis seen in conjunction with the reported genetic diversity commonly observed between and within species demonstrate that Atlantic and Pacific L. salmonis should be regarded as two subspecies: Lepeophtheirus salmonis salmonis and L. salmonis oncorhynchi subsp. nov.
Source: BMC Genetics - Latest articles - March 14, 2014 Category: Genetics & Stem Cells Authors: Rasmus Skern-MauritzenOle TorrissenKevin Glover Source Type: research

Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients.
CONCLUSION: Infection and high neutrophil counts are associated with a poorer cancer-specific survival in colorectal cancer patients. PMID: 25320529 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Attiê R, Chinen LT, Yoshioka EM, Silva MC, de Lima VC Tags: World J Gastroenterol Source Type: research

Posterior spinal cord infarctions due to neurosyphilis
An 86-year-old patient with multiple vascular risk factors including 3 previous strokes woke up with a sensation of wet lower limbs, with bilateral loss of proprioception in legs on examination. Cervical MRI showed 2 acute medullary ischemic lesions in the posterior columns at level C3 and C4 (figure 1, A–D). Biological screening including HIV serology, Treponema pallidum hemagglutination assay (TPHA), Venereal Disease Research Laboratory test (VDRL), and Lyme disease serology showed an increased TPHA titer of 1:320, with a negative VDRL.
Source: Nature Clinical Practice - December 8, 2014 Category: Neurology Authors: Bill, O., Du Pasquier, R. A., Michel, P. Tags: CT, Parasitic infections, Clinical neurology examination, All Cerebrovascular disease/Stroke, Spinal cord infarction Cases Source Type: research

The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma Cruzi infection in CD‐1 mice
This article is protected by copyright. All rights reserved.
Source: Diabetes/Metabolism Research and Reviews - January 1, 2015 Category: Endocrinology Authors: Wunnie Brima, Daniel J. Eden, Syed Faizan Mehdi, Michelle Bravo, Mohammad M. Wiese, Joanna Stein, Vanessa Almonte, Dazhi Zhao, Irwin Kurland, Jeffrey E. Pessin, Tomas Zima, Herbert B. Tanowitz, Louis M. Weiss, Jesse Roth, Fnu Nagajyothi Tags: Research Article Source Type: research

Cerebral myiasis
An 85-year-old patient was admitted to the emergency room septic with fetid odor in the right orbit, where enucleation of the right eye had been performed 8 years prior. Physical inspection noted the presence of larvae within the right orbit. After a CT scan (figure 1), the patient underwent surgical treatment (figure 2). Intraoperative cultures revealed encephalitis caused by myiasis. The patient died due to complications caused by sepsis 2 weeks after the procedure.
Source: Neurology - January 26, 2015 Category: Neurology Authors: Holanda, L. F., Pereira, B. J. A., de Holanda, C. V. M., de Oliveira, J. G. Tags: CT, Parasitic infections, Coma, All Cerebrovascular disease/Stroke, Critical care NEUROIMAGES Source Type: research

High-salt diet could protect against invading microbes
Most people consume more salt than they need and therefore have a higher risk of heart disease and stroke, which are the two leading causes of death worldwide. But a new study reveals that dietary salt could have a biological advantage: Defending the body against invading microbes. A high-salt diet increased sodium accumulation in the skin of mice, thereby boosting their immune response to a skin-infecting parasite.
Source: ScienceDaily Headlines - March 3, 2015 Category: Science Source Type: news

Brachial Plexus Neuritis as Presenting Manifestation of Disseminated Coccidioidomycosis. (P6.323)
CONCLUSIONS:This is the first reported case of coccidioidomycosis presenting with PNS involvement. Both remote inflammatory changes and direct local fungal invasion noted in this case highlight the wide spectrum of clinico-pathological presentations seen in coccidioidomycosis infection. As this fungal disease is identified with increasing frequency, clinicians should be aware of its atypical manifestations. Study Supported by: Disclosure: Dr. Shah has nothing to disclose. Dr. Liao has nothing to disclose. Dr. Shanina has nothing to disclose. Dr. Smith has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shah, R., Liao, B., Shanina, E., Smith, G. Tags: Fungi, Parasites, and Other Infectious Disorders Source Type: research

Chagas disease as a cause of heart failure and ventricular arrhythmias in patients long removed from endemic areas: an emerging problem in Europe
We report two examples of Chagas cardiomyopathy in South American women permanently residing in Italy for more than 20 years, presenting with cardiac manifestations ranging from left ventricular dysfunction and heart failure to isolated ventricular arrhythmias. The present review emphasizes that Chagas disease should be considered as a potential diagnosis in patients from endemic areas presenting with ‘idiopathic’ cardiac manifestations, even when long removed from their country of origin, with potential implications for treatment and control of Chagas disease transmission.
Source: Journal of Cardiovascular Medicine - October 30, 2015 Category: Cardiology Tags: Arrhythmias Source Type: research

Post-translational Protein Modifications of Rare and Unconventional Types: Implications in Functions and Diseases.
Abstract Protein post-translational modification (PTM) occurs following their biosynthesis and is a key cellular event that defines their ultimate functional properties. It is an important control mechanism for display of biological functions of proteins often in a profound manner. It may switch on or off a protein's function. Several studies have been conducted to understand their mechanisms, physiological pathways and functional properties. PTMs have been shown to alter structural, conformational and physicochemical properties of proteins. So far a variety of protein modifications have been detected in physiolog...
Source: Current Medicinal Chemistry - January 17, 2016 Category: Chemistry Authors: Basak S, Lu C, Basak A Tags: Curr Med Chem Source Type: research

Neuropharmacologic Approaches to Restore the Brain’s Microenvironment
Abstract Maintaining the central nervous system microenvironment after injury, infection, inflammatory and degenerative diseases is contingent upon adequate control of glial homeostatic functions. Disease is caused by microbial, environmental and endogenous factors that compromise ongoing nervous system functions. The final result is neuronal injury, dropout and nerve connection loss, and these underlie the pathobiology of Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, stroke, and bacterial, parasitic and viral infections. However, what promotes disease are homeostatic changes in the brain...
Source: Journal of NeuroImmune Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Source Type: research

Neuropharmacologic Approaches to Restore the Brain ’s Microenvironment
Abstract Maintaining the central nervous system microenvironment after injury, infection, inflammatory and degenerative diseases is contingent upon adequate control of glial homeostatic functions. Disease is caused by microbial, environmental and endogenous factors that compromise ongoing nervous system functions. The final result is neuronal injury, dropout and nerve connection loss, and these underlie the pathobiology of Alzheimer ’s and Parkinson’s disease, amyotrophic lateral sclerosis, stroke, and bacterial, parasitic and viral infections. However, what promotes disease are homeostatic changes in the brain’s mi...
Source: Journal of NeuroImmune Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Source Type: research